Protein Alignment ATP8A and ATP9A

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: NP_006036.1
• Gene: ATP9A / 10079
• HGNCID: 13540
• Length: 1047
• Species: Homo sapiens
• Alignment Length: 1062
• Identity: 310/1062 - (29%)
• Similarity: 524/1062 - (49%)
• Gaps: 128/1062 - (12%)

  Fly   217 RIINLNGPQ--PTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRY 279
            |.:.|..|:  ..:|..|.|...||:|.:|||..||.||:.:.|.:|||:|..|.:||:.....|
Human    39 RTVWLGHPEKRDQRYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLGALY 103

  Fly   280 TTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINTF 344
            |..|||.|:|:|:.|:|.:|:|:.:..|.|:|.:...||.:.....|:.|.:.|||:|.|..|..
Human   104 TYWVPLGFVLAVTVIREAVEEIRCYVRDKEVNSQVYSRLTARGTVKVKSSNIQVGDLIIVEKNQR 168

  Fly   345 FPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELLETKDLQRLEGRIECELPNRHLY 409
            .|||:|.|.:||....||:.|..|||||:.|:|..:..|..|....||.::...:..|.||..::
Human   169 VPADMIFLRTSEKNGSCFLRTDQLDGETDWKLRLPVACTQRLPTAADLLQIRSYVYAEEPNIDIH 233

  Fly   410 EFNGVL-RETGKPPAALGNDQVLQRGAILRNTAW---------VFGIVVYSGQETKLMKNSTSAP 464
            .|.|.. ||...||        :.....:.||.|         |.|:|:|:|:|.:.:.|:::..
Human   234 NFVGTFTREDSDPP--------ISESLSIENTLWAGTVVASGTVVGVVLYTGRELRSVMNTSNPR 290

  Fly   465 LKRSTVDKLTN--TQILMLFMILISLCIISGLCNLFWTREHSETDWYLGLTDFKTKSLGYNLLTF 527
            .|....|...|  |:||...::::||.:::        .:|....|||            .::.|
Human   291 SKIGLFDLEVNCLTKILFGALVVVSLVMVA--------LQHFAGRWYL------------QIIRF 335

  Fly   528 FILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTP-AMARTSNLNEELGMVKYIFSDKT 591
            .:|::|:|||||:|.|::.:.:.:..|..|       |..| .:.|:|.:.|:||.:.|:.:|||
Human   336 LLLFSNIIPISLRVNLDMGKIVYSWVIRRD-------SKIPGTVVRSSTIPEQLGRISYLLTDKT 393

  Fly   592 GTLTQNVMEFKKCSIAGYVYTAERTPEESQLVQNILG------------------RHETSAVIEE 638
            ||||||.|.||:..:....|..:...|....:.:|..                  |...|:.:.|
Human   394 GTLTQNEMIFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQSQDPPAQKGPTLTTKVRRTMSSRVHE 458

  Fly   639 FLELLSVCHTVIPERKENG--------------NMIYHAASPDERALVEGAQKFGYIFDTRTPKY 689
            .::.:::||.|.|..:.||              ..:|.|:||||.|||:..:..|.....|....
Human   459 AVKAIALCHNVTPVYESNGVTDQAEAEKQYEDSCRVYQASSPDEVALVQWTESVGLTLVGRDQSS 523

  Fly   690 VEINALGVR-KRYEVLNVLEFTSSRKRMSLIVRTPE-NKIKLFCKGADTVIYERLAPQGQAFREQ 752
            :::...|.: ..:.:|.:..||...|||.:|||... .:|..:.||||.|:         |...|
Human   524 MQLRTPGDQILNFTILQIFPFTYESKRMGIIVRDESTGEITFYMKGADVVM---------AGIVQ 579

  Fly   753 TLRHLEE----FASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLR 813
            ....|||    .|.:|||.|.:|...:..:.||::...:.:|.:::.:|..|:......:|..:.
Human   580 YNDWLEEECGNMAREGLRVLVVAKKSLAEEQYQDFEARYVQAKLSVHDRSLKVATVIESLEMEME 644

  Fly   814 LLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEESLD 878
            ||..|.:||:||..|..|:.:|.:|||.:|:|||||.|||.....:..|::.:.||.:..   |.
Human   645 LLCLTGVEDQLQADVRPTLETLRNAGIKVWMLTGDKLETATCTAKNAHLVTRNQDIHVFR---LV 706

  Fly   879 ATREVIHRHYGEFKSSSAKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKA 943
            ..|...|.....|:    :..:.||||.|.:|:..|.. ...:|.:|...|..|:|||.:|.|||
Human   707 TNRGEAHLELNAFR----RKHDCALVISGDSLEVCLKY-YEYEFMELACQCPAVVCCRCAPTQKA 766

  Fly   944 EVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVH 1008
            ::|.::.:.|..:|.|:|||.|||:|||:::.|:|:.|.||.||:.|:|:||.||::|.|||:||
Human   767 QIVRLLQERTGKLTCAVGDGGNDVSMIQESDCGVGVEGKEGKQASLAADFSITQFKHLGRLLMVH 831

  Fly  1009 GAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFE 1073
            |..:|.|.:.|..:..::::|:..::..|:....::...|::.:.|..|:.::|..|.|:: :.:
Human   832 GRNSYKRSAALSQFVIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPVFSL-VLD 895

  Fly  1074 KFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKTSDY 1138
            |...:|..:.||.|||.....:..:.|.|.||:..::.....:.:..|..:          .|::
Human   896 KDVKSEVAMLYPELYKDLLKGRPLSYKTFLIWVLISIYQGSTIMYGALLLF----------ESEF 950

  Fly  1139 LLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMFKFASNFRGMD 1203
            :.:..:.:|.:|:|..|...|...:|.||..:|...|:..:...|:          |...|  :|
Human   951 VHIVAISFTSLILTELLMVALTIQTWHWLMTVAELLSLACYIASLV----------FLHEF--ID 1003

  Fly  1204 IQLLSTPVFYFCLMLVPITTLL 1225
            :..::|..|.:.:.::.:.:.|
Human  1004 VYFIATLSFLWKVSVITLVSCL 1025

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	287/939 (31%)
ATP9A	NP_006036.1	P-type_ATPase_APLT_Neo1-like	55..967	CDD:319841	292/974 (30%)
		Cation_ATPase	464..571	CDD:463817	30/106 (28%)