Protein Alignment ATP8A and atp11c

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: XP_004917005.2
• Gene: atp11c / 100498300
• XenbaseID: XB-GENE-976439
• Length: 1149
• Species: Xenopus tropicalis
• Alignment Length: 1129
• Identity: 407/1129 - (36%)
• Similarity: 628/1129 - (55%)
• Gaps: 115/1129 - (10%)

  Fly   225 QPTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFIL 289
            || |:.:|||.::||:..:|:|..|||||||.:|.:||:|.::|.|.: :||...|:.:||.|::
 Frog    37 QP-KFCDNRIVSSKYTIWNFIPKNLFEQFRRIANFYFLIIFLIQAIVD-TPTSPVTSGLPLFFVI 99

  Fly   290 SVSAIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWSE-LTVGDIIKVGINTFFPADLILLS 353
            :|:|||:..||..|||||:|:|..::..:: ||.|..:.|| :.||||::|..|..||.||::||
 Frog   100 TVTAIKQGYEDWLRHRADHEVNKSTVYVIE-GSKCVKKESEKIKVGDIVEVRDNETFPCDLVMLS 163

  Fly   354 SSEPQAMCFIETANLDGETNLKIRQALPATAELLETKDLQRLEGRIECELPNRHLYEFNG---VL 415
            :|.....|.:.||:||||:|.|...|:|.||.|...:||......||||.|...||:|:|   |.
 Frog   164 TSCRDGTCTVTTASLDGESNFKTYHAVPETAILATYEDLNAFSATIECEQPQPDLYKFHGRIDVN 228

  Fly   416 RETGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILM 480
            ........:||.:.:|.:||.|:||..::|:.||:|.|||:..|......|||.|:|..|..:::
 Frog   229 TNQDVKARSLGPENLLLKGATLKNTKKIYGVAVYTGMETKMALNYQGKSQKRSAVEKSINAFLIV 293

  Fly   481 LFMILISLCIISGLCNLFW-TREHSETDWYLGLT-----DFKTKSLGYNLLTFFILYNNLIPISL 539
            ...||:|...|.......| :...::..||...|     .||...:..:.|:|.:|:|.:||:|:
 Frog   294 YLCILVSKATICTSLKYLWQSNPANDEPWYNEKTRKEKEAFKILKMFTDFLSFMVLFNFIIPVSM 358

  Fly   540 QVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKC 604
            .||:|:.:||.:.||.:|:||:.||.|..|:..||:||||||.|:|:|:|||||||:|.|||.:|
 Frog   359 YVTVEMQKFLGSFFIAWDMEMFDEEINEGALVNTSDLNEELGQVEYVFTDKTGTLTENKMEFIEC 423

  Fly   605 SIAGYVYTAERTPEESQLVQNILGRHETSAVIEE-FLELLSVCHTVI---------PERKENGNM 659
            .|.|:.|......:...|...:....:.|..:|| ||..|.:||||.         |......|.
 Frog   424 CIDGHKYANTDAMDGLSLTDGLAYFGKASQDLEELFLRALCLCHTVQMKEECHTDGPSFSSTDNC 488

  Fly   660 IYHAASPDERALVEGAQKFGYIFDTRTPKYVEINALGVR------KRYEVLNVLEFTSSRKRMSL 718
            .|.::||||.|||.||:::|:     |....|.|.:.|.      :||::|:||.|...|:|||:
 Frog   489 AYISSSPDEIALVTGAKRYGF-----TYMGTENNVMSVENQKNEIERYQLLHVLNFDPVRRRMSV 548

  Fly   719 IVRTPENKIKLFCKGADTVIYERLAPQGQAFREQTLR---HLEEFASDGLRTLCLAVADIRPDVY 780
            :|:....||.|||||||:.::.|:|      |:|..|   |:|:.|.||.||||:|..::..::|
 Frog   549 LVKAKTGKIFLFCKGADSSMFPRVA------RDQVQRIKVHVEKNALDGYRTLCVAFKEVSQELY 607

  Fly   781 QEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVL 845
            :..::..::|.:|||:||.:|....:.||.::.||||||:|||||:...|||.:|..||:.:|||
 Frog   608 ENINKQLEEAKLALQDREERLAKVYDDIEADMHLLGATAVEDRLQEQAAETIEALHAAGMKVWVL 672

  Fly   846 TGDKQETAINIGYSCRLISHSMDIIILNEESL-------DATREVIHRHYGEFKSSSAK------ 897
            ||||.|||.:..|:|||...:.:::.|..:.|       |..:|::..::.:....:.|
 Frog   673 TGDKLETAKSTCYACRLFQSNTELLELTTKDLEEYERKEDRLQELLMEYHRKLVQEAPKLKGGAN 737

  Fly   898 -----DANVALVIDGTTLKYAL-----SCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQS 952
                 :.:..|:|||.||...|     |...:|.|..:|..|..|:|||::|:|||::|:||..:
 Frog   738 RSWTGNQDHGLIIDGATLSLILNSNCSSSHYKNIFLQICQKCSAVLCCRMAPLQKAQIVKMVKNT 802

  Fly   953 TNA-VTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARI 1016
            ..: :||::|||||||:||.:|:|||||.|.||.|||.:|||::.:|::|::|||.||...|.||
 Frog   803 KGSPITLSVGDGANDVSMILEAHVGIGIKGKEGRQAARSSDYAVPKFKHLRKLLLAHGHLYYVRI 867

  Fly  1017 SKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETM 1081
            :.|:.|.||||:|..:.:..:..:.|:|.|.|::...:.:||:.||:||..|..|.|:....|.:
 Frog   868 AHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYNICFTSMPILAYSLLEQRINIEIL 932

  Fly  1082 IRYPMLY-KTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIW-------------SD 1132
            ...|.|| :.|.||.|       .|       ..||:|..|.|:...|.:             .:
 Frog   933 SSNPKLYMRISDNAML-------QW-------GPFLYWTLLGAFEGLVFFFGVYFLFQNPALEGN 983

  Fly  1133 GKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSH-VWPMFKFA 1196
            |:.......|.:|:|.::.||.||..|.|..|||:.|||||||:..:..|.|.:.. :||..|..
 Frog   984 GQVYGNWSFGTMVFTILVFTVTLKLALDTRYWTWMNHLAIWGSLAFYVIFSLFWGGIIWPFLKQQ 1048

  Fly  1197 SNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKTLTEAVRETE----------IR 1251
            ..:......|.|..::...::|: ..:|..:::..||.|  .||..:...:..          :.
 Frog  1049 RMYFVFSHILTSVSIWLGIILLI-FVSLYPEIVLILVKN--LKTANQKEHQLSSCSLKPPAITVS 1110

  Fly  1252 RSDISEVMNEP------RSSDSGF 1269
            ...|..:..:|      :|.::||
 Frog  1111 HGMIKRISYQPPVLISYKSMENGF 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	362/942 (38%)
atp11c	XP_004917005.2	P-type_ATPase_APLT_Dnf-like	42..971	CDD:319770	365/955 (38%)
		7TMR-DISM_7TM	954..>1071	CDD:429600	32/116 (28%)