Protein Alignment ATP8A and atp10a

DIOPT Version :9

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: XP_002931688.2
• Gene: atp10a / 100494528
• XenbaseID: XB-GENE-6033735
• Length: 1492
• Species: Xenopus tropicalis
• Alignment Length: 1369
• Identity: 435/1369 - (31%)
• Similarity: 655/1369 - (47%)
• Gaps: 327/1369 - (23%)

  Fly   209 YDADDGERRIINLNGPQPTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEV 273
            |::|:..|           .|..|.|.|.||:.:||||..|||||.|.:|.:|:.:|:|..:|.|
 Frog    47 YESDNPNR-----------LYAGNSIKTTKYTALSFLPKNLFEQFHRLANVYFVFMALLNFVPAV 100

  Fly   274 SPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVR-------WSEL 331
            :.......|.|::|||:|:|||::.||.:|:|:|.||||     :|...:|...       |.|:
 Frog   101 NAFKPELALAPVLFILAVTAIKDLWEDYRRYRSDKEINH-----MDCLVFCRSEKKYREKYWKEV 160

  Fly   332 TVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELLETKDLQRLE 396
            .|||.:::..|...|||::|||||:|..:|.|||||||||||||.||.:....||....|....:
 Frog   161 QVGDFVQLRCNEIIPADILLLSSSDPDGLCHIETANLDGETNLKQRQVVKGFVELESEFDPMTFK 225

  Fly   397 GRIECELPNRHLYEFNGVLRETGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNST 461
            ..||||.||..|..|.|.:.:.|| .:.|..:.:|.||..:|||..|.|||:|:|.|||.:.|:.
 Frog   226 SIIECEKPNNDLTRFRGYIHKNGK-KSGLFKENLLLRGCTIRNTEVVSGIVIYAGHETKALLNNN 289

  Fly   462 SAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHSET----DWYLGLTDFKTK---S 519
            ....|||.:::..|..:....:||:.:|:.|.:.:..|..::.|.    | .||......|   |
 Frog   290 GPRYKRSKLERQMNKDVFWCVLILLIMCLFSAVGHALWVWQYGEKRPVFD-VLGSDGKYVKPFLS 353

  Fly   520 LGYNLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVK 584
            ..|...|..|:...|||:||.|::|:|:..|..||:.|.::|.||:::....|..|:.|:||.::
 Frog   354 AVYLFFTMIIVLQVLIPVSLYVSIEIVKICQVYFIHQDKDLYDEETDSQLQCRALNITEDLGQIQ 418

  Fly   585 YIFSDKTGTLTQNVMEFKKCSIAGYVY-------------------------------------- 611
            |:|||||||||:|.|.|::|:::|..|
 Frog   419 YVFSDKTGTLTENKMVFRRCTVSGVEYSHDDNAKRLAMYQEADSEDEVNGPKTGTLPRRDSSGSH 483

  Fly   612 -------------TAERTPEESQLVQ-NILGRH-------------------------------- 630
                         |..||...::.:: |||.:|
 Frog   484 HSVKAAHRSQSTKTHRRTGSRAEAMKANILSKHTAFSSPMEKDITPDPKLQEKVNECAKTLKIMR 548

  Fly   631 -----------ETSAVIEEFLELLSVCHTVIP--------------------------------- 651
                       |.|.:. :|...|::|:||:.
 Frog   549 NHKQPFSQLTAELSDIF-DFFTALTICNTVVVTSPNQPRQKVRVRFELKSPVKTIEDFIRRFTPS 612

  Fly   652 ----------------------------------------ERK---------------------- 654
                                                    |||
 Frog   613 RLTSGSNSSSSSSLGTNKSMHRAGSSIMSSSSIEGSFTKLERKLSSSPQINFTGLGTQPGFKEQV 677

  Fly   655 --ENGNMIYHAASPDERALVEGAQKF-----GYIFDTRTPKYVEINALGVRKRYEVLNVLEFTSS 712
              ..|::.:.|.||||.|||..::.:     |.:.|..|   ||:..|| |..:|:|:.|.|.|.
 Frog   678 DGHEGDLRFEAESPDEAALVYASRAYNCALVGRLSDQVT---VELPHLG-RLNFELLHTLGFDSV 738

  Fly   713 RKRMSLIVRTP-ENKIKLFCKGADTVIY---------ERLAPQGQAFREQTLRHLEEFASDGLRT 767
            |||||::||.| .::|.::.||||:||.         :||....:..:.:|.::|..:|.|||||
 Frog   739 RKRMSVVVRHPLTDEIVVYAKGADSVILDLIQPCSKDDRLGKHQRKIQAKTQKYLNCYAVDGLRT 803

  Fly   768 LCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETI 832
            ||:|...:..:.|..|.:...:|..:|.|||..|..:|..:|.||.|||||.||||||:||||||
 Frog   804 LCIAKRVLSKEEYACWLKFHLQAESSLDNREELLFQSAVRLETNLHLLGATGIEDRLQEGVPETI 868

  Fly   833 ASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEESLDATREVIHR--HYGEFKSSS 895
            ..|..|||.||||||||||||:||||||:|:.|..|:|.||.|||:....::.:  ||.:.|.||
 Frog   869 TRLRKAGIQIWVLTGDKQETAVNIGYSCKLLDHEDDLITLNAESLEECSTLLEQCLHYIQSKFSS 933

  Fly   896 A------------------------KDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCR 936
            .                        |.:::.|||||.||.:||.....:.|..|...||.|:|||
 Frog   934 GLQEKVVGGTGIDSVQHNTLWPPNLKQSSLGLVIDGKTLAFALDITQSDKFLLLARKCRSVLCCR 998

  Fly   937 VSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYL 1001
            .:|:||:.||::|.....|:|||:|||.|||:|||.|:||:||||.||:||..|||:::.:||:|
 Frog   999 STPLQKSLVVKLVRDKLRAMTLAVGDGTNDVSMIQVADVGVGISGQEGMQAVMASDFAVPRFRHL 1063

  Fly  1002 QRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPP 1066
            ::||||||.|.|:|::.::||.||||.....:..|:..|.|:||..:.::|.:..:|:||:::|.
 Frog  1064 EKLLLVHGRWCYSRLANMVLYFFYKNAMFVALLFWYQFYCGFSGSAMIDQWYLIFFNLLFSSIPQ 1128

  Fly  1067 FAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWS 1131
            ...|:.:|...||.:...|.|||:..|.:.:...:||:.:.:|...|:..|::|..::....|
 Frog  1129 LITGILDKDLPAELLTANPELYKSGPNMEEYKPHMFWLNMIDAFYQSLVCFFIPYFSFFDSDI-- 1191

  Fly  1132 DGKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMFKFA 1196
                 |....|..:.|..::|:.:..|:.|.:|||:...:|..||:|:|...|:|:...|.....
 Frog  1192 -----DLFTWGTPIVTCALLTIMMHLGMETKTWTWINVSSIVFSILLFFTVALVYNSSCPTCNPP 1251

  Fly  1197 SNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKTLTEAVRETEIRRSDISEVMNE 1261
            ||......:|::.|:||...:|.|:|.||...:.|.|..|:|.|..:..|
 Frog  1252 SNPYWTMQKLMANPLFYLICILSPVTALLPRFLYKSVQGTLFPTQIQLGR--------------- 1301

  Fly  1262 PRSSDSGFGYALGKLIRSSHILISHDHHP--------VSESSRTSNLRVE-----NLEMEADTEQ 1313
                         ||:|:         ||        :.:||..|.:|.:     |..:..:|.|
 Frog  1302 -------------KLLRA---------HPECLTGNFSILKSSTASEMRSKTTEPNNTSIALNTNQ 1344

  Fly  1314 QQQS 1317
            :|.:
 Frog  1345 RQNN 1348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	22/61 (36%)
		ATPase-Plipid	229..1247	CDD:273734	418/1264 (33%)
		E1-E2_ATPase	286..>371	CDD:278548	41/91 (45%)
		Cation_ATPase	645..741	CDD:289987	43/207 (21%)
		HAD_like	<942..1001	CDD:304363	33/58 (57%)
		PhoLip_ATPase_C	988..1240	CDD:292829	79/251 (31%)
atp10a	XP_002931688.2	P-type_ATPase_APLT_Dnf-like	58..1182	CDD:319770	382/1135 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010