Protein Alignment ATP8A and atp11a

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: XP_031752894.1
• Gene: atp11a / 100485769
• XenbaseID: XB-GENE-1010941
• Length: 1193
• Species: Xenopus tropicalis
• Alignment Length: 1183
• Identity: 436/1183 - (36%)
• Similarity: 658/1183 - (55%)
• Gaps: 113/1183 - (9%)

  Fly   185 MTASFLRRKRTEY-EDDEDFTSSAGYDADDGERRIINLNGPQ---------PTKYGNNRITTAKY 239
            |..|.|||....| ..:|::.          :.|.|.:...|         |.:|.:|||.::||
 Frog     1 MDCSALRRLINRYCAGEENWV----------DNRTIYVGHKQPPPGTEAYIPQRYPDNRIVSSKY 55

  Fly   240 SFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRH 304
            :|.:|:|..|||||||.:|.:||:|.::|.|.: :||...|:.:||.|:::|:|||:..||..||
 Frog    56 TFWNFVPKNLFEQFRRIANFYFLIIFLVQLIID-TPTSPVTSGLPLFFVITVTAIKQGYEDWLRH 119

  Fly   305 RADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLD 369
            :|||.:|..|:..:..|.....:..:|.||||:.|..:..||.||:.||||.....||:.||:||
 Frog   120 KADNAMNQYSVHVVQHGKLVRTQSRKLRVGDIVMVREDEAFPCDLVFLSSSREDGTCFVTTASLD 184

  Fly   370 GETNLKIRQALPATAELLETKDLQRLEGRIECELPNRHLYEFNG---VLRETGKPPA-ALGNDQV 430
            ||::.|...|:..|......::::.|...||||.|...||:|.|   :..|..:|.| .||::.:
 Frog   185 GESSHKTYYAINDTKSFHHEEEMEGLHATIECEQPQPDLYKFVGRINIYNEADEPVARPLGSENL 249

  Fly   431 LQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLC 495
            |.|||.|:||..:||:.:|:|.|||:..|..|...|||.|:|..|..:::...||||..:|:.:.
 Frog   250 LLRGATLKNTEKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNAFLIVYLCILISKALINTVL 314

  Fly   496 NLFWTREHSETD-WYLGLTDF---KTKSLG--YNLLTFFILYNNLIPISLQVTLELVRFLQAIFI 554
            ...|..:.|..: ||...||.   |.|.||  .:.|.|.:|:|.:||:|:.||:|:.:||.:.||
 Frog   315 KYIWQSDSSRDEPWYNQKTDSERQKNKFLGAFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFI 379

  Fly   555 NYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVYTAERTPE- 618
            ::|.||:.|.:....:..||:||||||.|:|||:|||||||:|.|||.:|.|.|:||    .|.
 Frog   380 SWDEEMFDETTGEGPIVNTSDLNEELGQVEYIFTDKTGTLTENNMEFVECCIEGHVY----IPHV 440

  Fly   619 --ESQLVQNILG--------------RHETSAVIEEFLELLSVCHTV-------IPERKENG--- 657
              ..|::.:.:|              |.|.      |...|.:||||       |...|::.
 Frog   441 ICNGQILPDCMGIDMIDSSPGAGGKEREEL------FFRALCLCHTVQVKDEDHIDGEKKSSHSG 499

  Fly   658 -NMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEI-NALGVRKRYEVLNVLEFTSSRKRMSLIV 720
             :.:|.::||||.|||||.|:.||.|......|:|| |.....:::|:|.||.|.|.|:|||:||
 Frog   500 RSSVYISSSPDEVALVEGVQRLGYTFLRVKDNYMEICNRENDIEKFELLQVLTFDSVRRRMSVIV 564

  Fly   721 RTPENKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQ 785
            |:....|.|||||||:.|:.|:. :|:.  :|....:|..|.:||||||:|......|.| ||:.
 Frog   565 RSSTGDIYLFCKGADSSIFPRVR-EGKV--DQIRARVERNAVEGLRTLCVAYKKFSQDEY-EWAN 625

  Fly   786 TFDK-ASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDK 849
            ...| |.:|||:||.||.:|...||.:|.||||||:|||||:...:||.||..|||.:|||||||
 Frog   626 KLLKDAQLALQDREKKLAEAYEQIEQDLILLGATAVEDRLQEKAADTIESLQKAGIKVWVLTGDK 690

  Fly   850 QETAINIGYSCRLISHSMDIIIL-----NEESL-----DATREVIHRH-----YGEFKSSSAKDA 899
            .|||....|:|:|...:..::.|     .|:||     :.:|.|: ||     ...|...|....
 Frog   691 METASATCYACKLFRRNTQLLELTTKRIEEQSLHDVLFELSRTVL-RHSESLTRDNFSGFSTDFQ 754

  Fly   900 NVALVIDGTTLKYAL-------SCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQS-TNAV 956
            :..|:|||.||...:       |.:.|..|.::|..|..|:|||::|:|||::|:::..| .:.:
 Frog   755 DYGLIIDGATLSLIMKPREDGSSTNYREVFLEICRNCSAVLCCRMAPLQKAQIVKLIKSSREHPI 819

  Fly   957 TLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLIL 1021
            |||:|||||||:||.:|:||||:.|.||.|||..|||:|.:|::|:|:||:||.:.|.|||:|:.
 Frog   820 TLAVGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKRMLLIHGHYYYVRISELVQ 884

  Fly  1022 YSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPM 1086
            |.||||||....:..:..:.|:|.|.|::...:.|||:.||::|.....|.|:..:.:.:.|.|.
 Frog   885 YFFYKNVCFIFPQFLYQFFCGFSQQPLYDTAYLTLYNISFTSLPILLYSLIEQHVSVDVLKRDPT 949

  Fly  1087 LYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKTSDYLLMGNLVYTYVIV 1151
            ||:......|...::|..|.|..|..:...|:.....|....:.|:|:.......|.||:|.::.
 Frog   950 LYRDIAKNALLRWRLFIYWTFLGLFDAAVFFFGAYFLYDNATVTSNGQMLGNWTFGTLVFTVLVF 1014

  Fly  1152 TVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSH-VWPMFKFASNFRGMDIQLLSTPVFYFC 1215
            ||..|..|.|:.|||:.|..||||::.:..|.|::.. :||...:...:. :.||:||:...:..
 Frog  1015 TVTFKLALDTHYWTWINHFVIWGSLLFYIIFSLLWGGIIWPFLNYQRMYY-VFIQMLSSGPAWLG 1078

  Fly  1216 LMLVPITTLLIDVICKLVHNTVFKTLTEAVRETEIRRSDISE-----VMNEPRSSDSGFGYA--- 1272
            ::|:.|.:||.||:.|::...::.|.||.:::..:|..::||     .|..|....:.|..|
 Frog  1079 IVLLIIVSLLPDVLRKVICRQLWPTATERIQDASMRSKEVSEFTPLATMQSPTYQSNEFNTATPS 1143

  Fly  1273 ----LGKLIRSSH 1281
                |.|.:..:|
 Frog  1144 RSNSLSKKVMLTH 1156

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	376/951 (40%)
atp11a	XP_031752894.1	P-type_ATPase_APLT_Dnf-like	47..983	CDD:319770	376/951 (40%)
		MelB	<891..>1092	CDD:441813	57/201 (28%)