DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8A and atp11a

DIOPT Version :9

Sequence 1:	NP_001137651.1	Gene:	ATP8A / 36488	FlyBaseID:	FBgn0259221	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	XP_031752894.1	Gene:	atp11a / 100485769	XenbaseID:	XB-GENE-1010941	Length:	1193	Species:	Xenopus tropicalis

Alignment Length:	1183	Identity:	436/1183 - (36%)
Similarity:	658/1183 - (55%)	Gaps:	113/1183 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 MTASFLRRKRTEY-EDDEDFTSSAGYDADDGERRIINLNGPQ---------PTKYGNNRITTAKY 239
            |..|.|||....| ..:|::.          :.|.|.:...|         |.:|.:|||.::||
Frog     1 MDCSALRRLINRYCAGEENWV----------DNRTIYVGHKQPPPGTEAYIPQRYPDNRIVSSKY 55

  Fly   240 SFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRH 304
            :|.:|:|..|||||||.:|.:||:|.::|.|.: :||...|:.:||.|:::|:|||:..||..||
Frog    56 TFWNFVPKNLFEQFRRIANFYFLIIFLVQLIID-TPTSPVTSGLPLFFVITVTAIKQGYEDWLRH 119

  Fly   305 RADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLD 369
            :|||.:|..|:..:..|.....:..:|.||||:.|..:..||.||:.||||.....||:.||:||
Frog   120 KADNAMNQYSVHVVQHGKLVRTQSRKLRVGDIVMVREDEAFPCDLVFLSSSREDGTCFVTTASLD 184

  Fly   370 GETNLKIRQALPATAELLETKDLQRLEGRIECELPNRHLYEFNG---VLRETGKPPA-ALGNDQV 430
            ||::.|...|:..|......::::.|...||||.|...||:|.|   :..|..:|.| .||::.:
Frog   185 GESSHKTYYAINDTKSFHHEEEMEGLHATIECEQPQPDLYKFVGRINIYNEADEPVARPLGSENL 249

  Fly   431 LQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLC 495
            |.|||.|:||..:||:.:|:|.|||:..|..|...|||.|:|..|..:::...||||..:|:.:.
Frog   250 LLRGATLKNTEKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNAFLIVYLCILISKALINTVL 314

  Fly   496 NLFWTREHSETD-WYLGLTDF---KTKSLG--YNLLTFFILYNNLIPISLQVTLELVRFLQAIFI 554
            ...|..:.|..: ||...||.   |.|.||  .:.|.|.:|:|.:||:|:.||:|:.:||.:.||
Frog   315 KYIWQSDSSRDEPWYNQKTDSERQKNKFLGAFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFI 379

  Fly   555 NYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVYTAERTPE- 618
            ::|.||:.|.:....:..||:||||||.|:|||:|||||||:|.|||.:|.|.|:||    .|.
Frog   380 SWDEEMFDETTGEGPIVNTSDLNEELGQVEYIFTDKTGTLTENNMEFVECCIEGHVY----IPHV 440

  Fly   619 --ESQLVQNILG--------------RHETSAVIEEFLELLSVCHTV-------IPERKENG--- 657
              ..|::.:.:|              |.|.      |...|.:||||       |...|::.
Frog   441 ICNGQILPDCMGIDMIDSSPGAGGKEREEL------FFRALCLCHTVQVKDEDHIDGEKKSSHSG 499

  Fly   658 -NMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEI-NALGVRKRYEVLNVLEFTSSRKRMSLIV 720
             :.:|.::||||.|||||.|:.||.|......|:|| |.....:::|:|.||.|.|.|:|||:||
Frog   500 RSSVYISSSPDEVALVEGVQRLGYTFLRVKDNYMEICNRENDIEKFELLQVLTFDSVRRRMSVIV 564

  Fly   721 RTPENKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQ 785
            |:....|.|||||||:.|:.|:. :|:.  :|....:|..|.:||||||:|......|.| ||:.
Frog   565 RSSTGDIYLFCKGADSSIFPRVR-EGKV--DQIRARVERNAVEGLRTLCVAYKKFSQDEY-EWAN 625

  Fly   786 TFDK-ASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDK 849
            ...| |.:|||:||.||.:|...||.:|.||||||:|||||:...:||.||..|||.:|||||||
Frog   626 KLLKDAQLALQDREKKLAEAYEQIEQDLILLGATAVEDRLQEKAADTIESLQKAGIKVWVLTGDK 690

  Fly   850 QETAINIGYSCRLISHSMDIIIL-----NEESL-----DATREVIHRH-----YGEFKSSSAKDA 899
            .|||....|:|:|...:..::.|     .|:||     :.:|.|: ||     ...|...|....
Frog   691 METASATCYACKLFRRNTQLLELTTKRIEEQSLHDVLFELSRTVL-RHSESLTRDNFSGFSTDFQ 754

  Fly   900 NVALVIDGTTLKYAL-------SCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQS-TNAV 956
            :..|:|||.||...:       |.:.|..|.::|..|..|:|||::|:|||::|:::..| .:.:
Frog   755 DYGLIIDGATLSLIMKPREDGSSTNYREVFLEICRNCSAVLCCRMAPLQKAQIVKLIKSSREHPI 819

  Fly   957 TLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLIL 1021
            |||:|||||||:||.:|:||||:.|.||.|||..|||:|.:|::|:|:||:||.:.|.|||:|:.
Frog   820 TLAVGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKRMLLIHGHYYYVRISELVQ 884

  Fly  1022 YSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPM 1086
            |.||||||....:..:..:.|:|.|.|::...:.|||:.||::|.....|.|:..:.:.:.|.|.
Frog   885 YFFYKNVCFIFPQFLYQFFCGFSQQPLYDTAYLTLYNISFTSLPILLYSLIEQHVSVDVLKRDPT 949

  Fly  1087 LYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKTSDYLLMGNLVYTYVIV 1151
            ||:......|...::|..|.|..|..:...|:.....|....:.|:|:.......|.||:|.::.
Frog   950 LYRDIAKNALLRWRLFIYWTFLGLFDAAVFFFGAYFLYDNATVTSNGQMLGNWTFGTLVFTVLVF 1014

  Fly  1152 TVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSH-VWPMFKFASNFRGMDIQLLSTPVFYFC 1215
            ||..|..|.|:.|||:.|..||||::.:..|.|::.. :||...:...:. :.||:||:...:..
Frog  1015 TVTFKLALDTHYWTWINHFVIWGSLLFYIIFSLLWGGIIWPFLNYQRMYY-VFIQMLSSGPAWLG 1078

  Fly  1216 LMLVPITTLLIDVICKLVHNTVFKTLTEAVRETEIRRSDISE-----VMNEPRSSDSGFGYA--- 1272
            ::|:.|.:||.||:.|::...::.|.||.:::..:|..::||     .|..|....:.|..|
Frog  1079 IVLLIIVSLLPDVLRKVICRQLWPTATERIQDASMRSKEVSEFTPLATMQSPTYQSNEFNTATPS 1143

  Fly  1273 ----LGKLIRSSH 1281
                |.|.:..:|
Frog  1144 RSNSLSKKVMLTH 1156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	27/70 (39%)
		ATPase-Plipid	229..1247	CDD:273734	415/1081 (38%)
		E1-E2_ATPase	286..>371	CDD:278548	35/84 (42%)
		Cation_ATPase	645..741	CDD:289987	46/107 (43%)
		HAD_like	<942..1001	CDD:304363	32/59 (54%)
		PhoLip_ATPase_C	988..1240	CDD:292829	81/252 (32%)
atp11a	XP_031752894.1	P-type_ATPase_APLT_Dnf-like	47..983	CDD:319770	376/951 (40%)
atp11a	XP_031752894.1	RDD	<965..1061	CDD:412544	29/95 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010