Protein Alignment ATP8A and atp8b5a

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: XP_021332106.1
• Gene: atp8b5a / 100330945
• ZFINID: ZDB-GENE-060531-48
• Length: 1205
• Species: Danio rerio
• Alignment Length: 1186
• Identity: 473/1186 - (39%)
• Similarity: 680/1186 - (57%)
• Gaps: 141/1186 - (11%)

  Fly   191 RRKRTEYE-----DDEDFTSSAGYDADDGERRIINLNGPQPTKYGNNRITTAKYSFISFLPAFLF 250
            |:|..|.|     :|.::.||                    .||..|.|.|:||:..||||..||
Zfish    10 RKKEKEVERKIRANDREYNSS--------------------FKYATNCIKTSKYNPFSFLPLNLF 54

  Fly   251 EQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSI 315
            |||:|.:|.:||.:.|||.||.:|....:||:|||:.:|||:|.|:.|:||.|||:|.::|:|.:
Zfish    55 EQFQRIANAYFLFLLILQVIPAISSLSWFTTVVPLVLVLSVTAAKDAIDDINRHRSDRQVNNRKV 119

  Fly   316 ERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQAL 380
            ..|.||...:.:|..:.||||||:..|.|..|||:|||||||..:.:||||.||||||||::|:|
Zfish   120 NVLISGKLTSEKWMNVQVGDIIKLENNQFVTADLLLLSSSEPLNLVYIETAELDGETNLKVKQSL 184

  Fly   381 PATAEL---LETKDLQRLEGRIECELPNRHLYEFNGVLR-ETGKPPAALGNDQVLQRGAILRNTA 441
            ..|.::   ||.  |....|.:.||.||..|..|.|.|. :|.|  .:|.|::||.||..||||.
Zfish   185 TVTGDMGHNLEA--LAAFNGEVCCEPPNNRLDRFTGTLTFDTQK--YSLDNERVLLRGCTLRNTD 245

  Fly   442 WVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTR----- 501
            |.||:|:::|.|||||:|...:..||:::|:|.|..:|.:|.:|..:|||..:.:..|..
Zfish   246 WCFGLVLFAGPETKLMQNCGKSTFKRTSIDRLMNVLVLFIFALLALMCIILAVGHGIWENYTGSK 310

  Fly   502 -----EHSETDWYLGLTDFKTKSLGYNLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMY 561
                 .|.|...:.....|         .::.|:.|.::||||.|::|::|...:.:||:|..||
Zfish   311 FNVFLPHEENAAFSAFLTF---------WSYIIILNTVVPISLYVSMEVIRLGNSYYINWDRNMY 366

  Fly   562 HEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVY--------------T 612
            |..::|||.|||:.||||||.:||||||||||||||:|.|.||||.|..|              |
Zfish   367 HTRTDTPAEARTTTLNEELGQIKYIFSDKTGTLTQNIMTFNKCSINGKSYGDVFQHYSGQTLEIT 431

  Fly   613 AERTP---------------EESQLVQNI-LGRHETSAVIEEFLELLSVCHTVIPERKENGNMIY 661
            .|.||               .:..||:.: |...|..|    |..||::|||.:.|.|:.|:::|
Zfish   432 EETTPVDFSFNGLADPKFLFYDHSLVEAVKLELPEVHA----FFRLLALCHTCMAEEKKEGHLVY 492

  Fly   662 HAASPDERALVEGAQKFGYIFDTRTPKYVEINALGVRKRYEVLNVLEFTSSRKRMSLIVRTPENK 726
            .|.||||.|||..|:.||::|.:|:|:.:.|..:|:::.||:|.:|:|.:.|||||:|||.||.|
Zfish   493 QAQSPDEGALVTAARNFGFVFRSRSPETITIEEMGIQRTYELLAILDFNNVRKRMSVIVRNPEGK 557

  Fly   727 IKLFCKGADTVIYERLAPQGQAFREQTLRHLEEFASDGLRTLCLAVADIRPDVYQEWSQTFDKAS 791
            :.|:||||||:|||||.|......|.|..||.|||.:|||||.||..|:..|.:.||.|...::|
Zfish   558 LSLYCKGADTIIYERLHPSCSKLMEVTTEHLNEFAGEGLRTLVLAYKDLDEDYFAEWKQRHHESS 622

  Fly   792 VALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVLTGDKQETAINI 856
            ||:::||.||:.....||.::.|:|||||||:|||||..||..|..|.|.||||||||||||.||
Zfish   623 VAMEDREEKLDKVYEEIEKDMMLIGATAIEDKLQDGVALTIELLAKAEIKIWVLTGDKQETAENI 687

  Fly   857 GYSCRLISHSM-DIIILNEESLDATREVIHRHYGEFKSSSAKD---------------------- 898
            ||||.|:...| |:.|:...|.:..|:.:.....:.:.|:.:|
Zfish   688 GYSCNLLREEMNDVFIVAAHSPEEVRQELRDARLKMQPSTEQDKFLIPEVILGNTPKVVQDEHVN 752

  Fly   899 ANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAIGDG 963
            ....|||:|.:|.:||...:..:|.....:|:.||||||:|:|||:|||:|.:...|||||||||
Zfish   753 GEYGLVINGHSLAFALESSMELEFLRTACMCKTVICCRVTPLQKAQVVELVKRYKKAVTLAIGDG 817

  Fly   964 ANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNV 1028
            ||||:||:.|::|:||||.||:||..:||:|.||||:|||||||||.|:|.|:.|.:.|.||||.
Zfish   818 ANDVSMIKAAHIGVGISGQEGMQAVLSSDFSFAQFRFLQRLLLVHGRWSYLRMCKFLRYFFYKNF 882

  Fly  1029 CLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKTSQN 1093
            ....:..|:|.:.|:|.|.:::...|.|||:::||:|...|.||::...|...:.:|.||...|.
Zfish   883 TFTFVHFWYAFFCGFSAQTVYDEGFITLYNLVYTALPVLGMSLFDQDVNANWSLEFPQLYVPGQL 947

  Fly  1094 AKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKT-SDYLLMGNLVYTYVIVTVCLKA 1157
            ::.|:.:.|.:...::...|:.||::|.|. |.:...:||:. :||.....:..|.:.||||::.
Zfish   948 SQYFSKRAFMMCALHSCYSSLVLFFVPYAT-TYDTARADGRDGADYQSFALITQTCLTVTVCVQL 1011

  Fly  1158 GLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMFK-----FASNFRGMDIQLLSTPVFYFCLM 1217
            ||..:.||.:.||.:|||:.::| ||....:...:||     ||  |.|.....|:.|..:..:.
Zfish  1012 GLDLSYWTVVNHLFVWGSLGMFF-FLTFTMYTDGLFKLRPASFA--FIGTARNCLNQPNVWLTVA 1073

  Fly  1218 LVPITTLLIDVICKLVHNTVFKTLTEAVRETEIRRSDISEVMNEP---------RSSDSGFGYAL 1273
            |..:..:|..|..:.::..::.|:.:.|| .::|:      |.||         |.|....|||.
Zfish  1074 LTALLCVLPVVAYRFIYCQIYPTINDKVR-YKMRQ------MKEPAPRPRPRLTRRSTRRSGYAF 1131

  Fly  1274 ------GKLIRSSHIL 1283
                  |.|:.|...|
Zfish  1132 SHAQGYGDLVTSRRFL 1147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	413/955 (43%)
atp8b5a	XP_021332106.1	P-type_ATPase_APLT_Dnf-like	36..974	CDD:319770	413/954 (43%)