Protein Alignment ATP8A and atp8a2

DIOPT Version :10

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: XP_068075181.2
• Gene: atp8a2 / 100330943
• ZFINID: ZDB-GENE-100209-2
• Length: 1223
• Species: Danio rerio
• Alignment Length: 1236
• Identity: 645/1236 - (52%)
• Similarity: 829/1236 - (67%)
• Gaps: 90/1236 - (7%)

  Fly   154 RSSNRKDSKG-----SILSRQS--------GKSRVSLLAQRGLRMTASFLRRKR--------TEY 197
            |.|.:..|:|     :.||:.|        |.:..|.||.|..:.:........        |.|
Zfish     5 RRSKKIHSEGEQLVLTPLSQDSPLRQDQPLGPNMCSRLADRFEKTSPPLFHHSNGAGPACSATGY 69

  Fly   198 EDDEDFTSSAGYDAD--DGERRIINLNGPQPTKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCF 260
            ...||..|.....||  |...|.:.||..|.|||.:|.::||||..::|||.||:||.||.:|.|
Zfish    70 RKAEDEMSGTTSQADPVDATARTVLLNRAQTTKYCDNHVSTAKYGILTFLPRFLYEQIRRAANAF 134

  Fly   261 FLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIERLDSGSWCT 325
            ||.||::||||:|||||||||||||:|||:|:.|||||||.|||:|||.:|.:....|.:|:|.|
Zfish   135 FLFIALMQQIPDVSPTGRYTTLVPLIFILTVAGIKEIIEDYKRHKADNTVNKKKTTVLRNGAWQT 199

  Fly   326 VRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELLETK 390
            :.|.::.||||:||......|||::::|||||||||:.||:||||||||||||.|..||.....:
Zfish   200 IIWKQVAVGDIVKVTNGQHLPADMVIVSSSEPQAMCYTETSNLDGETNLKIRQGLSLTASFQSLE 264

  Fly   391 DLQRLEGRIECELPNRHLYEFNGVLRETGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETK 455
            ||..|.||:|||.||||||:|.|.||.....||.||.||||.|||.||||.||.|||||:|.::|
Zfish   265 DLIALSGRLECEGPNRHLYDFTGTLRLDNHNPAPLGPDQVLLRGAQLRNTQWVVGIVVYTGHDSK 329

  Fly   456 LMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTREHS-ETDWYLGLTDFKTKS 519
            ||:|||.||||||.|:::||.|||:||.||:.:.::|.:....|.::|: |..|||......:.:
Zfish   330 LMQNSTKAPLKRSNVERVTNMQILVLFGILLVMALVSSIGAAIWNKQHTDEACWYLSRAGDISLN 394

  Fly   520 LGYNLLTFFILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVK 584
            ..||||||.|||||||||||.||||:|:|.||:|||:|:|||:.|::|||||||||||||||.||
Zfish   395 FAYNLLTFIILYNNLIPISLLVTLEVVKFTQALFINWDVEMYYAETDTPAMARTSNLNEELGQVK 459

  Fly   585 YIFSDKTGTLTQNVMEFKKCSIAGYVY--------------------TAERTPE--ESQLVQNIL 627
            |:|||||||||.|||.||||:|||..|                    |:..:.|  :..|:|||.
Zfish   460 YLFSDKTGTLTCNVMHFKKCTIAGITYGHFPDLDCDRSMEDFSHLPSTSHNSTEFDDPALIQNIE 524

  Fly   628 GRHETSAVIEEFLELLSVCHTVIPERKENGNMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEI 692
            ..|.||..|.|||.:::|||||:|||::| .:||.|:||||.|||:||:..|::|..|||..|.|
Zfish   525 KNHPTSPQICEFLTMMAVCHTVVPEREDN-QIIYQASSPDEGALVKGAKSLGFVFTARTPHSVII 588

  Fly   693 NALGVRKRYEVLNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQAFREQTLRHL 757
            .|.|..:.||:||||||:|:|||||:|||||...::|:|||||.||:|||....| ::|.|:.||
Zfish   589 EARGKEQTYELLNVLEFSSNRKRMSVIVRTPTGNLRLYCKGADNVIFERLNVTSQ-YKELTVAHL 652

  Fly   758 EEFASDGLRTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIED 822
            |:||::||||||.|..|:....|.||.:.:::.|..|::|..|||:...|||.||.|||||||||
Zfish   653 EQFATEGLRTLCFAYVDLEEGAYLEWLKEYNRISTVLKDRAQKLEECYELIEKNLLLLGATAIED 717

  Fly   823 RLQDGVPETIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSMDIIILNEESLDATREVIHRH 887
            |||.|||||||:|:.|.|.|||||||||||||||||||||:||.|.:||:||:||||||..:..|
Zfish   718 RLQAGVPETIATLMRADIKIWVLTGDKQETAINIGYSCRLVSHGMSLIIVNEDSLDATRATLTAH 782

  Fly   888 YGEFKSSSAKDANVALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKAEVVEMVTQS 952
            ......|..|:..:||:|||.|||||||.::|..|.||.:.|:.||||||||:||:|:|:||.:.
Zfish   783 CSSLGDSLRKENELALIIDGQTLKYALSFEVRQAFLDLALSCKAVICCRVSPLQKSEIVDMVKKH 847

  Fly   953 TNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARIS 1017
            ..|:|||||||||||.|||.|:||:||||.||:||..:||||||||.||::||||||||:|.|::
Zfish   848 VKAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNSSDYSIAQFSYLEKLLLVHGAWSYNRVT 912

  Fly  1018 KLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMI 1082
            |.|||.|||||.||:||||||..:|:|||||||||.||||||:|||:|||.:|:|::.|:.:.||
Zfish   913 KCILYCFYKNVVLYIIELWFAFVNGFSGQILFERWCIGLYNVIFTALPPFTLGIFDRPCSQQNMI 977

  Fly  1083 RYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKTSDYLLMGNLVYT 1147
            |:|.||:.:|||:.||.||||....|||:||:.|||.||.|...:..:.:|.:.|||.:||:|||
Zfish   978 RFPQLYRITQNAEGFNTKVFWGHCINALIHSIILFWFPLKALEHDTPFDNGNSVDYLFVGNIVYT 1042

  Fly  1148 YVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMFKFASNFRGMDIQLLSTPVF 1212
            ||:||||||||:.|.:||..:|||:|||:|||..|..:||.:||....|.:..|...:::....|
Zfish  1043 YVVVTVCLKAGMETTAWTRFSHLAVWGSMVLWMLFFAVYSAIWPTIPIAPDMLGQAGRVMQCWSF 1107

  Fly  1213 YFCLMLVPITTLLIDVICKLVHNTVFKTLTEAVRETEIR---------RSDISEVMNEP------ 1262
            :..|:|||...||.||:......||.|||.|.|:|.|.|         |......:||.
Zfish  1108 WLGLILVPTACLLKDVVWNAGRRTVRKTLLEEVQELEARAVDPGAAVLRDASGRSLNERAHLLTR 1172

  Fly  1263 --RSSDSGFGYALGKLIRSSHI--LISH-------DHHPVSESSRTSNLRVENLEMEADTEQQQQ 1316
              |.:.|..|       ||:.:  .:||       :|..||:|         .:....||.:|:.
Zfish  1173 VFRKTPSSVG-------RSNSVQQTVSHGYAFSQEEHGVVSQS---------QVVRSYDTTRQRP 1221

  Fly  1317 S 1317
            |
Zfish  1222 S 1222

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	P-type_ATPase_APLT_Dnf-like	231..1120	CDD:319770	540/911 (59%)
atp8a2	XP_068075181.2	None