DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8A and atp8b1

DIOPT Version :9

Sequence 1:	NP_001137651.1	Gene:	ATP8A / 36488	FlyBaseID:	FBgn0259221	Length:	1350	Species:	Drosophila melanogaster
Sequence 2:	XP_001920510.4	Gene:	atp8b1 / 100148342	ZFINID:	ZDB-GENE-091116-14	Length:	1249	Species:	Danio rerio

Alignment Length:	1180	Identity:	451/1180 - (38%)
Similarity:	671/1180 - (56%)	Gaps:	164/1180 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 TKYGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSV 291
            ::|..|.|.|.||:.::|||..|:|||:|.:|.:||.:.:||.||::|....|||||||:.:|.:
Zfish    84 SRYSGNAIKTYKYNVLTFLPLNLYEQFKRAANLYFLCLLVLQIIPQISTLPWYTTLVPLVLVLGI 148

  Fly   292 SAIKEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSE 356
            :|||::::|:.|||.|.|||:|..:.|.:|.:...||..|.|||::::..|.|.|||::|||:|.
Zfish   149 TAIKDLVDDLARHRMDKEINNRKCDVLLNGRFVETRWMNLQVGDVVRLHKNDFIPADIMLLSTSN 213

  Fly   357 PQAMCFIETANLDGETNLKIRQALPATAE-LLETKDLQRLEGRIECELPNRHLYEFNGVLRETGK 420
            |.::|::|||.||||||||.:..|..|.| |.|.:.|.:....:.||.||..|.:|.|.:....:
Zfish   214 PNSLCYVETAELDGETNLKFKMGLKVTDERLQEEQQLSQFNALVMCEEPNNRLDKFVGTMIWESQ 278

  Fly   421 PPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFMIL 485
             ..||..|.:|.||..:|||....|:|:::|.:||:|:|......||:.:|||.|..:..:|::|
Zfish   279 -SYALDLDNMLLRGCKVRNTDICHGLVIFAGNDTKIMRNGGKTRFKRTRIDKLMNYMVYTIFVLL 342

  Fly   486 ISLCIISGLCNLFWTREHSETDWYL--GLTDFKTKSLGYNLLTFF---ILYNNLIPISLQVTLEL 545
            :.||....:.:.:|........|||  || |:.:...|:  |:|:   |:.|.::||||.|::|:
Zfish   343 VLLCAGLAIGHTYWYESIGSKAWYLIDGL-DYTSSYRGF--LSFWGYIIILNTMVPISLYVSVEV 404

  Fly   546 VRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYV 610
            :|..|:.|||:|::||:.:.:|||.:||:.|||:||.::|||||||||||||:|.||||:|:|..
Zfish   405 IRLGQSKFINWDLQMYYADKDTPAKSRTTTLNEQLGQIEYIFSDKTGTLTQNIMAFKKCTISGRT 469

  Fly   611 YTAERTP-------------------------EESQLVQNILGRHETSAVIEEFLELLSVCHTVI 650
            |....|.                         |:..|:..|  |.:....:.||.:|||:||||:
Zfish   470 YGEPTTADGVSLDRGKPVDFSWNKYADRKFQFEDHFLISCI--RSKKDPQVLEFFKLLSLCHTVM 532

  Fly   651 PERKENGNMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEINALGVRKRYEVLNVLEFTSSRKR 715
            .|.|| |.::|.||||||.|||..|:.||::|.:||...:.|..:...:.|.:|.:|:|.|.|||
Zfish   533 VEEKE-GELVYQAASPDEGALVTAARNFGFVFLSRTQDTITIQEMDKPQTYTMLALLDFNSDRKR 596

  Fly   716 MSLIVRTPENKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEEFASDGLRTLCLAVADIRPDVY 780
            ||:|::.|:.:|:|:|||||||||:||:||.:. :|.|...|:.||::.||||||...||..:.:
Zfish   597 MSIILKFPDGRIRLYCKGADTVIYQRLSPQSKN-KENTQEALDIFANETLRTLCLCYKDISQEEF 660

  Fly   781 QEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDAGIYIWVL 845
            ..||:....|:|::.:||.:|::....||.:|.|:|||||||:||||||||||.|..|.|.||||
Zfish   661 DRWSRKHQTAAVSMVDRERELDEVYEEIEKDLLLIGATAIEDKLQDGVPETIAKLAKADIKIWVL 725

  Fly   846 TGDKQETAINIGYSCRLISHSMDIIILNEESLDATREVIHRHYGEFKSSSAKDANV--------- 901
            ||||:|||.||||||:|::..|.|                 ||||       |.||
Zfish   726 TGDKKETAENIGYSCQLLTDDMKI-----------------HYGE-------DVNVQLRNRQTQR 766

  Fly   902 ----------------------ALVIDGTTLKYAL-------------SCDLR------------ 919
                                  ||:|.|..|...|             ...||
Zfish   767 RTDPQSRNKKQKESFFNEPGKNALIITGGWLNEILYEKKKKRRRLRLKKLRLRQNNQQSSSSTAP 831

  Fly   920 ---------------NDFQDLCILCRVVICCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAM 969
                           .||.|:...|..||||||:|.|||.||.:|.:...||||:||||||||.|
Zfish   832 DSSQPVDDWEKEKRQEDFVDMACECSAVICCRVTPKQKANVVSLVKKYKKAVTLSIGDGANDVNM 896

  Fly   970 IQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIE 1034
            |:.|::|:||||.||:||..:|||:.|||.:|||||||||.|:|.|:.|.:.|.||||....::.
Zfish   897 IKTADIGVGISGQEGMQAVMSSDYAFAQFCFLQRLLLVHGRWSYIRMCKFLRYFFYKNFAFTLVH 961

  Fly  1035 LWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNV 1099
            .||:.::|:|.|..:|.|.|.||||.::::|...:||.::....:..:|:|.||...|...|||.
Zfish   962 FWFSFFNGFSAQTAYEDWFITLYNVCYSSLPVLLVGLLDQDVNDKLSLRFPKLYLPGQQGALFNY 1026

  Fly  1100 KVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGKT-SDYLLMGNLVYTYVIVTVCLKAGLITNS 1163
            :.|:|.:|:.:..|:.:|::|..|:. :.:..||:. |||.....:..:.:|:||.|:..|.|:.
Zfish  1027 RNFFISLFHGIFTSLMIFFIPYGAFL-QTMGQDGEAPSDYQSFAVVAASSLIITVNLQISLNTSY 1090

  Fly  1164 WTWLTHLAIWGSIVLWFGFLL-IYS---HVWPMFKFASNFRGMDIQLLSTPVFYFCLMLVPITTL 1224
            ||::...|:.|||.|:||.:. |:|   ||  :|.....|.|.....|..|..:..::|. :...
Zfish  1091 WTFVNFFAVLGSIALYFGIMFDIHSAGIHV--IFPNTFTFTGAASNALRQPYLWLTIILT-VGVC 1152

  Fly  1225 LIDVIC-KLVHNTVFKTLTEAV----RETEIRRSDISEVMNEP------RSSDSGF------GY- 1271
            |:.||| :.::.|::.::.:.|    ::.|:...:......:|      ||..|.:      ||
Zfish  1153 LLPVICIQFLYQTIYPSVGDKVQRNRKKYELEDEEDERKKRKPTFQRGGRSRRSAYAFSHSRGYA 1217

  Fly  1272 ---ALGKLIR 1278
               |.|:.||
Zfish  1218 DLIASGRSIR 1227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	22/52 (42%)
		ATPase-Plipid	229..1247	CDD:273734	440/1129 (39%)
		E1-E2_ATPase	286..>371	CDD:278548	37/84 (44%)
		Cation_ATPase	645..741	CDD:289987	48/95 (51%)
		HAD_like	<942..1001	CDD:304363	35/58 (60%)
		PhoLip_ATPase_C	988..1240	CDD:292829	89/257 (35%)
atp8b1	XP_001920510.4	PhoLip_ATPase_N	60..137	CDD:292826	22/52 (42%)
		ATPase-Plipid	86..1176	CDD:273734	440/1125 (39%)
		E1-E2_ATPase	142..>228	CDD:278548	38/85 (45%)
		Cation_ATPase	527..624	CDD:289987	49/97 (51%)
		HAD_like	<872..915	CDD:304363	26/42 (62%)
		PhoLip_ATPase_C	915..1169	CDD:292829	89/257 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.730