Protein Alignment ATP8A and atp8b4

DIOPT Version :9

• Sequence 1: NP_001137651.1
• Gene: ATP8A / 36488
• FlyBaseID: FBgn0259221
• Length: 1350
• Species: Drosophila melanogaster
• Sequence 2: XP_002936618.2
• Gene: atp8b4 / 100145017
• XenbaseID: XB-GENE-5831431
• Length: 1188
• Species: Xenopus tropicalis
• Alignment Length: 1163
• Identity: 469/1163 - (40%)
• Similarity: 698/1163 - (60%)
• Gaps: 107/1163 - (9%)

  Fly   229 YGNNRITTAKYSFISFLPAFLFEQFRRYSNCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSA 293
            |.||.|.|:||:.::|||..|||||:|.:|.:||.:.|||.|||:|....:||:|||:.:|:::|
 Frog    28 YANNAIKTSKYNIVTFLPINLFEQFQRVANAYFLFLLILQLIPEISSLSWFTTIVPLVLVLTITA 92

  Fly   294 IKEIIEDIKRHRADNEINHRSIERLDSGSWCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQ 358
            :|:..:|..||:.||::|:|..:.|.||.....:|..:..|||||:..|.|..||::|||||||.
 Frog    93 VKDATDDFFRHKTDNQVNNRQSQVLLSGKLQNEKWMNVRAGDIIKLENNQFVVADMLLLSSSEPH 157

  Fly   359 AMCFIETANLDGETNLKIRQALPATAELLETKDLQRL---EGRIECELPNRHLYEFNGVL--RET 418
            .:|::|||.||||||||:|||||.||:|.|:  :.||   :|.:.||.||..|.:|.|.|  ::.
 Frog   158 GLCYVETAELDGETNLKVRQALPVTADLGES--ITRLADFDGEVACEPPNNKLDKFTGTLIWKDN 220

  Fly   419 GKPPAALGNDQVLQRGAILRNTAWVFGIVVYSGQETKLMKNSTSAPLKRSTVDKLTNTQILMLFM 483
               ..:|.|.::|.||.::|||.|.||:|:::|.:||||:||.....||:::|:|.||.:|.:|.
 Frog   221 ---KYSLTNSKILLRGCVVRNTEWCFGMVIFAGPDTKLMQNSGKTKFKRTSIDRLMNTLVLWIFG 282

  Fly   484 ILISLCIISGLCNLFWTREH---SETDWYLGLTDFKTKSLGYNLLTFF---ILYNNLIPISLQVT 542
            .||.:.||..:.|..|  ||   |....||...:....|:....|||:   |:.|.::||||.|:
 Frog   283 FLICMGIILAIGNSIW--EHQVGSRFRIYLYWNEVVNSSVFSGFLTFWSYIIILNTVVPISLYVS 345

  Fly   543 LELVRFLQAIFINYDIEMYHEESNTPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIA 607
            :|::|...:.|||:|.:|::.:..|||..||:.||||||.::|||||||||||||:|.|.|||::
 Frog   346 VEVIRLGHSYFINWDRKMFYSKRGTPAETRTTTLNEELGQIEYIFSDKTGTLTQNIMTFNKCSVS 410

  Fly   608 GYVY-------------TAERTP----------EESQLVQNILGRHETSAV------IEEFLELL 643
            |.||             |.:..|          .:.|...:.|    |.|:      ::|...||
 Frog   411 GKVYGELRDELGRKVGITEKTAPVDFSFNPLADRKFQFYDHSL----TEAIKLEEPYVQEVFRLL 471

  Fly   644 SVCHTVIPERKENGNMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEINALGVRKRYEVLNVLE 708
            |:||||:.|.|..|.::|...||||.|||..|:.||:||.:|||:.:.:..:|....|::|.:|:
 Frog   472 SLCHTVMSEEKTAGELVYQVQSPDEGALVTAARNFGFIFKSRTPETITVEEMGKVVTYQLLAILD 536

  Fly   709 FTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEEFASDGLRTLCLAVA 773
            |.:.|||||:|||.||.::||:||||||:::|:|....:.....|..||.|||.:|||||.||..
 Frog   537 FNNIRKRMSVIVRNPEGQVKLYCKGADTILFEKLHESSEDLMYITSDHLNEFAGEGLRTLALAYK 601

  Fly   774 DIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPETIASLLDA 838
            |:..|..:.|.:...:||.||:|||.:|..|...||:|:.|||||||||:||:||.|||:|||.|
 Frog   602 DLSEDYLKWWLKIHHEASTALENREERLAAAYEEIESNMMLLGATAIEDKLQEGVIETISSLLLA 666

  Fly   839 GIYIWVLTGDKQETAINIGYSCRLISHSM-DIIILNEESLDATREVIHR------------HYGE 890
            .|.:|:|||||||||:||||||.:::..| :|.:::..::...||.:.:            :.|.
 Frog   667 NIKVWILTGDKQETAMNIGYSCHMLTDDMNEIFVISGHTVMEVREELRKAKECTFGQSRNLYNGH 731

  Fly   891 FKSSSAKDANV------------ALVIDGTTLKYALSCDLRNDFQDLCILCRVVICCRVSPMQKA 943
            ..|...:|..:            |:||:|.:|.:||..|:..:|.::..:|:.||||||:|:|||
 Frog   732 QFSEKMQDTKLDTVYEETVTGEYAMVINGHSLAHALEADMEKEFLEIACMCKTVICCRVTPLQKA 796

  Fly   944 EVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQFRYLQRLLLVH 1008
            :|||:|.:...||||||||||||::||:.|::|:||||.||:||..|||||.|||||||||||||
 Frog   797 QVVELVKKYKKAVTLAIGDGANDISMIKSAHIGVGISGQEGMQAVLASDYSFAQFRYLQRLLLVH 861

  Fly  1009 GAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTAMPPFAMGLFE 1073
            |.|:|.|:.|.:.|.||||....::..||..:.|:|.|.::::|.|.|:|:::|::|..|||||:
 Frog   862 GRWSYFRMCKFLCYFFYKNFAFTLVHFWFGFFCGFSAQTVYDQWFITLFNIVYTSLPVLAMGLFD 926

  Fly  1074 KFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEVIWSDGK-TSD 1137
            :....:..:.|..||:..|...|||.:.|:|.|.:.:..|..||::|..|:. .....||| .:|
 Frog   927 QDVNDQNCMDYTKLYEPGQLNLLFNKRRFFICIAHGIYTSFALFFIPFGAFF-NTAGEDGKHIAD 990

  Fly  1138 YLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFL----------LIYSHVWPM 1192
            |......|.|.:::.|.::.||.|:.||.:.|..||||:.::|..|          :..||
 Frog   991 YQSFAVTVATSLVIVVSVQIGLDTSYWTAINHFFIWGSLAVYFSILFAMHGDGIFDIFPSH---- 1051

  Fly  1193 FKFASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVICKLVHNTVFKTLTEAVR---ETEIRRSD 1254
            |.|..|.|..    ||....:..:.|..:..::..:..:.:...:..||::.||   :.:.||..
 Frog  1052 FPFVGNARNS----LSQKSVWLVIFLTTVICVMPVLTFRFLKADLSPTLSDKVRYLQQAKKRRKP 1112

  Fly  1255 ISEVMNE-PRSSDSGFGYAL------GKLIRSSHILISHDHHPVSESSRTSNLRVENL 1305
            :...|.. .|:|....|||.      |:||.|...:..::.|..|..::|::. :|||
 Frog  1113 LENRMRRVHRTSSRRSGYAFSHQEGYGELITSGKNMRVNNPHASSGLAKTTSW-IENL 1169

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8A	NP_001137651.1	PhoLip_ATPase_N	218..280	CDD:292826	26/50 (52%)
		ATPase-Plipid	229..1247	CDD:273734	451/1096 (41%)
		E1-E2_ATPase	286..>371	CDD:278548	36/84 (43%)
		Cation_ATPase	645..741	CDD:289987	46/95 (48%)
		HAD_like	<942..1001	CDD:304363	39/58 (67%)
		PhoLip_ATPase_C	988..1240	CDD:292829	88/262 (34%)
atp8b4	XP_002936618.2	P-type_ATPase_APLT_Dnf-like	30..973	CDD:319770	415/953 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010