DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18278 and Gns

DIOPT Version :9

Sequence 1:	NP_725289.1	Gene:	CG18278 / 36487	FlyBaseID:	FBgn0033836	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_083640.1	Gene:	Gns / 75612	MGIID:	1922862	Length:	544	Species:	Mus musculus

Alignment Length:	504	Identity:	229/504 - (45%)
Similarity:	308/504 - (61%)	Gaps:	27/504 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LAPLIILVL--ACLGNTASEKLPNILLILSDDQDVELRGMFPMEHTIEMLGFGGALFHNAYTPSP 66
            |..|::|.|  .|||...:.:.||:||:|:||||.||.||.|::.|..::|..|..|.:||.||.
Mouse    17 LPALLLLPLLGGCLGLVGAARRPNVLLLLTDDQDAELGGMTPLKKTKALIGEKGMTFSSAYVPSA 81

  Fly    67 ICCPARTSLLTGMYAHNHGTRNNSVSGGCYGPHWRRALEPRALPYILQQ-HGYNTFFGGKYLNQY 130
            :|||:|.|:|||.|.|||...||::.|.|....|::..||...|.||:. .||.|||.|||||:|
Mouse    82 LCCPSRASILTGKYPHNHHVVNNTLEGNCSSKAWQKIQEPYTFPAILKSVCGYQTFFAGKYLNEY 146

  Fly   131 WGAGD------VPKGWNHFYGLHGNSRYYNYTL------RENSGNVHYESTYLTDLLRDRAADFL 183
             ||.|      :|.||:::|.|..||:||||||      |::..|  |...||||:|.:.:.|||
Mouse   147 -GAPDAGGLEHIPLGWSYWYALEKNSKYYNYTLSINGKARKHGEN--YSVDYLTDVLANLSLDFL 208

  Fly   184 RNATQSSEPFFAMVAPPAAHEPFTPAPRHEGVFSHIEALRTPSFNQVKQDKHWLVRAARR-LPNE 247
             :...:|||||.|::.||.|.|:|.||:::..|.::.|.|..:||....:||||:|.|:. :.|.
Mouse   209 -DYKSNSEPFFMMISTPAPHSPWTAAPQYQKAFQNVIAPRNKNFNIHGTNKHWLIRQAKTPMTNS 272

  Fly   248 TINTIDTYFQKRWETLLAVDELVVTLMGVLNDTQSLENTYIIYTSDNGYHVGQFAQPFDKRQPYE 312
            :|..:|..|::||:|||:||:||..|:..|:.|..|:||||.||||||||.|||:.|.||||.||
Mouse   273 SIRFLDDAFRRRWQTLLSVDDLVEKLVKRLDSTGELDNTYIFYTSDNGYHTGQFSLPIDKRQLYE 337

  Fly   313 TDINVPLLIRGPGIAPESHIDTAVSLVDLAPTILAWADID-TPSYMDGQSFHELLLNKRRRVPFF 376
            .||.||||:|||||.|.......||.:||.||||..|..| ..:.|||.|...:|...|...  :
Mouse   338 FDIKVPLLVRGPGIKPNQTSKMLVSNIDLGPTILDLAGYDLNKTQMDGMSLLPILKGDRNLT--W 400

  Fly   377 ERSLLIEYWGEGTLATFNPECPWPEKDRLAQCTPAADCHCQDAWNNTYACLRNIRHREDRIYCEF 441
            ...:|:||.|||...| :|.|| .....::||.|  ||.|:||:||||||:|.:....:..||||
Mouse   401 RSDVLVEYQGEGRNVT-DPTCP-SLSPGVSQCFP--DCVCEDAYNNTYACVRTLSSLWNLQYCEF 461

  Fly   442 RDNENFLEAYDLQLDPFQMTNIAYDLLPIERALYSLRLKNLTQCSGHSC 490
            .|.|.|:|.|::..||.|:||||..:.|......:.||..|..|||.:|
Mouse   462 DDQEVFVEVYNITADPDQITNIAKSIDPELLGKMNYRLMMLQSCSGPTC 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18278	NP_725289.1	G6S	24..467	CDD:293766	214/457 (47%)
CG18278	NP_725289.1	AslA	24..464	CDD:225661	212/454 (47%)
Gns	NP_083640.1	AslA	35..496	CDD:225661	215/470 (46%)
Gns	NP_083640.1	G6S	38..487	CDD:293766	214/458 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847547
Domainoid	1	1.000	320	1.000	Domainoid score	I1231
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1568
Inparanoid	1	1.050	414	1.000	Inparanoid score	I1823
Isobase	1	0.950	-	0	Normalized mean entropy	S4445
OMA	1	1.010	-	-		QHG57985
OrthoDB	1	1.010	-	-		D1273622at2759
OrthoFinder	1	1.000	-	-		FOG0001009
OrthoInspector	1	1.000	-	-		oto95237
orthoMCL	1	0.900	-	-		OOG6_103483
Panther	1	1.100	-	-	O	PTHR43108
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5072
SonicParanoid	1	1.000	-	-		X5154
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.750