DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18278 and SGSH

DIOPT Version :9

Sequence 1:	NP_725289.1	Gene:	CG18278 / 36487	FlyBaseID:	FBgn0033836	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_000190.1	Gene:	SGSH / 6448	HGNCID:	10818	Length:	502	Species:	Homo sapiens

Alignment Length:	501	Identity:	131/501 - (26%)
Similarity:	186/501 - (37%)	Gaps:	129/501 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 NILLILSDDQDVEL----RGMFPMEHTIEMLGFGGALFHNAYTPSPICCPARTSLLTGMYAHNHG 85
            |.||:|:||...|.    .......| ::.|.....||.||:|....|.|:|.|||||:..|.:
Human    24 NALLLLADDGGFESGAYNNSAIATPH-LDALARRSLLFRNAFTSVSSCSPSRASLLTGLPQHQN- 86

  Fly    86 TRNNSVSGGCYG-----PHWRRALEPRALPYILQQHGYNTFFGGKYLNQYWGAGDV-PKGWNHFY 144
                    |.||     .|:....:.|:||.:|.|.|..|...||   ::.|...| |
Human    87 --------GMYGLHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGK---KHVGPETVYP------- 133

  Fly   145 GLHGNSRYYNYTLRENSGNVHYESTYLTD---LLRDRAADFLRNATQSSEPFFAMVAPPAAHEPF 206
                    :::...|.:|:|......:|.   |:|    .||:  ||...|||..||....|...
Human   134 --------FDFAYTEENGSVLQVGRNITRIKLLVR----KFLQ--TQDDRPFFLYVAFHDPHRCG 184

  Fly   207 TPAPRHEGVFSHIEALRTPSFNQVKQDKHWLVRAARRL--------PNETINTIDTYFQKRWETL 263
            ...|:: |.|............::..   |..:|...|        ||......|...|  :.|:
Human   185 HSQPQY-GTFCEKFGNGESGMGRIPD---WTPQAYDPLDVLVPYFVPNTPAARADLAAQ--YTTV 243

  Fly   264 LAVDELVVTLMGVLNDTQSLENTYIIYTSDNGYHVGQFAQPFDKRQPYETDINVPLLIRGP---- 324
            ..:|:.|..::..|.|...|.:|.:|:|||||     ...|..:...|......|||:..|
Human   244 GRMDQGVGLVLQELRDAGVLNDTLVIFTSDNG-----IPFPSGRTNLYWPGTAEPLLVSSPEHPK 303

  Fly   325 --GIAPESHIDTAVSLVDLAPTILAWADIDTPSY--MDGQSFHELLLNKRRRVPFFERSLLIEYW 385
              |...|::    |||:||.||||.|..|..|||  ...::.|   |..|..:|..|...|   |
Human   304 RWGQVSEAY----VSLLDLTPTILDWFSIPYPSYAIFGSKTIH---LTGRSLLPALEAEPL---W 358

  Fly   386 G---------EGTLA---------------TFNPECPWP-EKDRLAQCTPAADCHCQDAWNNTYA 425
            .         |.|::               ..|.:.|:| ::|.....|      .||..|.|.|
Human   359 ATVFGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPT------FQDLLNRTTA 417

  Fly   426 -----CLRNIRHREDRIYCEFRDNENFLEAYDLQLDPFQMTNIAYD 466
                 ..:::||    .|...|     .|.||...||.:..|:|.|
Human   418 GQPTGWYKDLRH----YYYRAR-----WELYDRSRDPHETQNLATD 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18278	NP_725289.1	G6S	24..467	CDD:293766	131/501 (26%)
CG18278	NP_725289.1	AslA	24..464	CDD:225661	129/497 (26%)
SGSH	NP_000190.1	SGSH	24..472	CDD:293751	131/501 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810