DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18278 and SULF2

DIOPT Version :9

Sequence 1:	NP_725289.1	Gene:	CG18278 / 36487	FlyBaseID:	FBgn0033836	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001373981.1	Gene:	SULF2 / 55959	HGNCID:	20392	Length:	871	Species:	Homo sapiens

Alignment Length:	475	Identity:	169/475 - (35%)
Similarity:	238/475 - (50%)	Gaps:	72/475 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PNILLILSDDQDVELRGMFPMEHTIEMLGFGGALFHNAYTPSPICCPARTSLLTGMYAHNHGTRN 88
            |||:|:|:|||||||..|..|..|..::..|||.|.||:..:|:|||:|:|:|||.|.|||.|..
Human    44 PNIILVLTDDQDVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKYVHNHNTYT 108

  Fly    89 NSVSGGCYGPHWRRALEPRALPYILQQHGYNTFFGGKYLNQYWGAGDVPKGWNHFYGLHGNSRYY 153
            |:.:  |..|.|:...|.|.....|...||.|.|.|||||:|.|: .||.||..:.||..|||:|
Human   109 NNEN--CSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYNGS-YVPPGWKEWVGLLKNSRFY 170

  Fly   154 NYTL-----RENSGNVHYESTYLTDLLRDRAADFLRNATQ--SSEPFFAMVAPPAAHEPFTPAPR 211
            ||||     :|..|: .|...|||||:.:.:..|.|.:.:  ...|...:::..|.|.|...||:
Human   171 NYTLCRNGVKEKHGS-DYSKDYLTDLITNDSVSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQ 234

  Fly   212 HEGVFSHIEALRTPSFNQV-KQDKHWLVR---AARRLPNETINTIDTYFQKRWETLLAVDELVVT 272
            :..:|.:.....|||:|.. ..||||::|   ..:.:..|..|.:.   :||.:||::||:.:.|
Human   235 YSRLFPNASQHITPSYNYAPNPDKHWIMRYTGPMKPIHMEFTNMLQ---RKRLQTLMSVDDSMET 296

  Fly   273 LMGVLNDTQSLENTYIIYTSDNGYHVGQFAQPFDKRQPYETDINVPLLIRGPGIAP---ESHIDT 334
            :..:|.:|..|:||||:||:|:|||:|||.....|..|||.||.||..:|||.:..   ..||
Human   297 IYNMLVETGELDNTYIVYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYVRGPNVEAGCLNPHI-- 359

  Fly   335 AVSLVDLAPTILAWADIDTPSYMDGQSFHELLLNKRRRVPFFERSLLIEYWGEGTLATFNPECPW 399
             |..:|||||||..|.:|.|:.|||:|..: ||:..|.|..|.....:..|.:..|.
Human   360 -VLNIDLAPTILDIAGLDIPADMDGKSILK-LLDTERPVNRFHLKKKMRVWRDSFLV-------- 414

  Fly   400 PEKDRLAQCTPAADCHCQDAWNNTYACLRNIRHREDRIYCEFRDNENFLEAYDLQLDPFQMTNIA 464
             |:.:|.                         |:.|....:.:: ||||..|....|..|
Human   415 -ERGKLL-------------------------HKRDNDKVDAQE-ENFLPKYQRVKDLCQ----- 447

  Fly   465 YDLLPIERALYSLRLKNLTQ 484
                   ||.|....:.|.|
Human   448 -------RAEYQTACEQLGQ 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18278	NP_725289.1	G6S	24..467	CDD:293766	164/456 (36%)
CG18278	NP_725289.1	AslA	24..464	CDD:225661	164/453 (36%)
SULF2	NP_001373981.1	G6S	43..385	CDD:293766	145/350 (41%)
		DUF3740	529..662	CDD:403667
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..588
		ALP_like	<750..799	CDD:419962
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157128
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1273622at2759
OrthoFinder	1	1.000	-	-		FOG0001009
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750