DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18278 and ARSL

DIOPT Version :9

Sequence 1:	NP_725289.1	Gene:	CG18278 / 36487	FlyBaseID:	FBgn0033836	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001269557.1	Gene:	ARSL / 415	HGNCID:	719	Length:	614	Species:	Homo sapiens

Alignment Length:	531	Identity:	125/531 - (23%)
Similarity:	181/531 - (34%)	Gaps:	179/531 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLAPLIILVLACLGNTASEKL----PNILLILSDD---QDVELRGMFPME-HTIEMLGFGGALFH 59
            |..|.::.||..|..:||..:    |||||:::||   .|:...|...|. ..|:.|...|....
Human    38 SWLPAMLAVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLT 102

  Fly    60 NAYTPSPICCPARTSLLTGMYAHNHGTRNNSVSGGCYGPHWRRALE----PRALP-------YIL 113
            ...:.:.:|.|:|.:.|||.|.    .|:..||...|     |.|:    ...||       .||
Human   103 QHISAASLCTPSRAAFLTGRYP----VRSGMVSSIGY-----RVLQWTGASGGLPTNETTFAKIL 158

  Fly   114 QQHGYNTFFGGKYLNQYWGAG------------DVPKGWNHFYG----LHGNSRYYNYTLRENSG 162
            ::.||.|...||     |..|            .:..|::||||    |.|:..  .:.|.|...
Human   159 KEKGYATGLIGK-----WHLGLNCESASDHCHHPLHHGFDHFYGMPFSLMGDCA--RWELSEKRV 216

  Fly   163 NVHYE-------------------------------------------STYLTDLLRDRAADFL- 183
            |:..:                                           |:|....|...|..||
Human   217 NLEQKLNFLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLLASSYFVGALIVHADCFLM 281

  Fly   184 RNATQSSEPF-FAMVAPPAAHE--PFTPAPRHEGVF--------SHIEALRTPSFNQVKQDKHWL 237
            ||.|.:.:|. |....|....|  .|....:| |.|        .||..:...:|         |
Human   282 RNHTITEQPMCFQRTTPLILQEVASFLKRNKH-GPFLLFVSFLHVHIPLITMENF---------L 336

  Fly   238 VRAARRLPNETINTIDTYFQKRWETLLAVDELVVTLMGVLNDTQSLENTYIIY-TSDNGYHVGQF 301
            .::...|..:.:..:|      |    .|..::.||     |.:.|.|:.:|| |||:|   |..
Human   337 GKSLHGLYGDNVEEMD------W----MVGRILDTL-----DVEGLSNSTLIYFTSDHG---GSL 383

  Fly   302 AQPFDKRQ---------------PYETDINVPLLIRGPGIAPESH-IDTAVSLVDLAPTI--LAW 348
            .......|               .:|..|.||.:.|.||:.|... |....||:|:.||:  ||.
Human   384 ENQLGNTQYGGWNGIYKGGKGMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAG 448

  Fly   349 ADIDTPSYMDGQSFHELLLNKRRR------VPFFERSLLIEYWGE---GTL-------ATFNPE- 396
            .::.....:|||....|||...:.      :.:.||.|....|.:   ||:       ..|.||
Human   449 GEVPQDRVIDGQDLLPLLLGTAQHSDHEFLMHYCERFLHAARWHQRDRGTMWKVHFVTPVFQPEG 513

  Fly   397 ---------CP 398
                     ||
Human   514 AGACYGRKVCP 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18278	NP_725289.1	G6S	24..467	CDD:293766	118/506 (23%)
CG18278	NP_725289.1	AslA	24..464	CDD:225661	118/506 (23%)
ARSL	NP_001269557.1	ALP_like	62..585	CDD:355016	118/507 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157151
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1273622at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750