DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18278 and CG7408

DIOPT Version :9

Sequence 1:	NP_725289.1	Gene:	CG18278 / 36487	FlyBaseID:	FBgn0033836	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001163462.1	Gene:	CG7408 / 39991	FlyBaseID:	FBgn0036765	Length:	585	Species:	Drosophila melanogaster

Alignment Length:	571	Identity:	124/571 - (21%)
Similarity:	206/571 - (36%)	Gaps:	188/571 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LAPLIILVLACLGNTASEKLPNILLILSDD---QDVELRG----MFPMEHTIEMLGFGGALFHNA 61
            |...::.:....|..|:...|||::|::||   .||..||    :.|   .|:.|.:.|.:.:|.
  Fly    15 LTGFVLCIALSNGIVATSDKPNIIIIMADDLGFDDVSFRGSNNFLTP---NIDALAYSGVILNNL 76

  Fly    62 YTPSPICCPARTSLLTGMYAHNHGTRNNSVSGGCYGPHWRRALEPRALPYILQQHGYNTFFGGKY 126
            |. :|:|.|:|.:||||.|..|.|.::..:..   ...|...|....:..|.:::||.|...||
  Fly    77 YV-APMCTPSRAALLTGKYPINTGMQHYVIVN---DQPWGLPLNETTMAEIFRENGYRTSLLGK- 136

  Fly   127 LNQYWGAG-------DVPKGWNHFYGLHG-------------NSRYYNYTLRENSGNVH-YESTY 170
                |..|       ...:|::...|..|             |..|..:..|::..:.| :...|
  Fly   137 ----WHLGLSQRNFTPTERGFDRHLGYLGAYVDYYTQSYEQQNKGYNGHDFRDSLKSTHDHVGHY 197

  Fly   171 LTDLLRDRAADFLRN--ATQSSEPFFAM---VAPPAAH--EPFTPAPRHEGVFSHIEALRTPSFN 228
            :||||.|.|...:.:  :..||:|.|.:   :||.||:  :|. .||..|  .|..|.:..
  Fly   198 VTDLLTDAAVKEIEDHGSKNSSQPLFLLLNHLAPHAANDDDPM-QAPAEE--VSRFEYISN---- 255

  Fly   229 QVKQDKHWLVRAARRLPNETINTIDTYFQKRWETLLAVDELVVTLMGVLNDTQSLENTYIIYTSD 293
              |..:::....:|                       :|:.|.:::..|...:.|:|:.|::.||
  Fly   256 --KTHRYYAAMVSR-----------------------LDKSVGSVIDALARQEMLQNSIILFLSD 295

  Fly   294 NG-------------YHV-GQFAQPFD---------------------KRQPYETDINVPLLIRG 323
            ||             |.: ||...|::                     |:|.|..|: :|.|...
  Fly   296 NGGPTQGQHSTTASNYPLRGQKNSPWEGALRSSAAIWSTEFERLGSVWKQQIYIGDL-LPTLAAA 359

  Fly   324 PGIAPES--HID-----------------TAVSLVDLAPTILAWADIDTP--SYMDG-------- 359
            .||:|:.  |:|                 ..|.::|        .|:..|  ||..|
  Fly   360 AGISPDPALHLDGLNLWSALKYGYESVEREIVHVID--------EDVAEPHLSYTRGKWKVISGT 416

  Fly   360 --QSFHELLLNKR-------RRVPFFERSLLIEYW--------GEGTLATFNP----ECPWPEKD 403
              |..::..|..|       |.|.:.|.......|        ||..::....    |||.|...
  Fly   417 TNQGLYDGWLGHRETSEVDPRAVEYEELVRNTSVWLQLQQVSFGERNISELRDQSRIECPDPATG 481

  Fly   404 RLAQCTPAADCHCQDAWNNTYACLRNIRH---REDRIYCEFRDNENFLEAY 451
             :..|.|...           .||.:|..   ....:|.|::::..||:.:
  Fly   482 -VKPCLPLEG-----------PCLFDIEADPCERSNLYAEYQNSTIFLDLW 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18278	NP_725289.1	G6S	24..467	CDD:293766	121/551 (22%)
CG18278	NP_725289.1	AslA	24..464	CDD:225661	121/551 (22%)
CG7408	NP_001163462.1	AslA	31..425	CDD:225661	100/446 (22%)
CG7408	NP_001163462.1	4-S	35..423	CDD:293753	100/440 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466492
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740