DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18278 and ARSI

DIOPT Version :9

Sequence 1:	NP_725289.1	Gene:	CG18278 / 36487	FlyBaseID:	FBgn0033836	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001012301.1	Gene:	ARSI / 340075	HGNCID:	32521	Length:	569	Species:	Homo sapiens

Alignment Length:	542	Identity:	118/542 - (21%)
Similarity:	189/542 - (34%)	Gaps:	177/542 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 NTASEKLPNILLILSDDQ---DVELRGMFPMEHTIEMLGFGGALFHNAYTPSPICCPARTSLLTG 78
            :.|..:.|:|:.||:|||   ||...|......|::.|...|....|.|. .|||.|:|:.||||
Human    40 SAAPPQPPHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAKGVKLENYYI-QPICTPSRSQLLTG 103

  Fly    79 MYAHNHGTRNNSV---SGGCYGPHWRRALEPRALPYILQQHGYNTFFGGKYLNQYWGAGDVP--K 138
            .|..:.|.:::.:   ...|.      .|:...||..||:.||:|...||:...::....:|  :
Human   104 RYQIHTGLQHSIIRPQQPNCL------PLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECLPTRR 162

  Fly   139 GWNHFYG-LHGNSRYYNYTLRENSG----------NVHY--ESTYLTDLLRDRAADFLRNATQSS 190
            |::.|.| |.||..||.|...:..|          ||.:  ...|.|.|...||:..|  |:.|.
Human   163 GFDTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGENVAWGLSGQYSTMLYAQRASHIL--ASHSP 225

  Fly   191 E-PFFAMVAPPAAHEPFTPAPRHEGVFSHIEALRTPSFNQVKQDKHWLVRAARRLPNETINTIDT 254
            : |.|..||..|.|.|                |::|        :.:|.|         ..|:..
Human   226 QRPLFLYVAFQAVHTP----------------LQSP--------REYLYR---------YRTMGN 257

  Fly   255 YFQKRWETLL-AVDELVVTLMGVLNDTQSLENTYIIYTSDNGYHVGQFAQPFDKRQPYETDINVP 318
            ..::::..:: .:||.|..:...|.......|:.||::||||            .|.:....|.|
Human   258 VARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNG------------GQTFSGGSNWP 310

  Fly   319 LL----------IRGPGIAPESHID-------TAVSLVDLAPTILAWADIDTPSYMDGQSFHEL- 365
            |.          :||.|......:.       ..:.:.|..||::..|. .|.|..||...:::
Human   311 LRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAG-GTTSAADGLDGYDVW 374

  Fly   366 -LLNKRRRVPFFE-----------------------------RSLLIEYW-------GEG----- 388
             .:::.|..|..|                             .::.:..|       |.|
Human   375 PAISEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPGYGDWIPP 439

  Fly   389 -TLATFNPECPWPEKDRLAQCTPAADCHCQDAWNNTYACLRNIRHREDRIYCEFRDNENFLEAYD 452
             |||||...  |...:|:|...       |..|                             .::
Human   440 QTLATFPGS--WWNLERMASVR-------QAVW-----------------------------LFN 466

  Fly   453 LQLDPFQMTNIAYDLLPIERAL 474
            :..||::..::|.....:.|.|
Human   467 ISADPYEREDLAGQRPDVVRTL 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18278	NP_725289.1	G6S	24..467	CDD:293766	115/526 (22%)
CG18278	NP_725289.1	AslA	24..464	CDD:225661	114/523 (22%)
ARSI	NP_001012301.1	4-S	48..478	CDD:293753	113/522 (22%)
ARSI	NP_001012301.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..539
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157145
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740