DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18278 and Sulf2

DIOPT Version :9

Sequence 1:	NP_725289.1	Gene:	CG18278 / 36487	FlyBaseID:	FBgn0033836	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001030099.1	Gene:	Sulf2 / 311642	RGDID:	1305078	Length:	875	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	173/490 - (35%)
Similarity:	243/490 - (49%)	Gaps:	79/490 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 PNILLILSDDQDVELRGMFPMEHTIEMLGFGGALFHNAYTPSPICCPARTSLLTGMYAHNHGTRN 88
            |||:|:|:|||||||..|..|..|..::..|||.|.||:..:|:|||:|:|:|||.|.|||.|..
  Rat    44 PNIILVLTDDQDVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKYVHNHNTYT 108

  Fly    89 NSVSGGCYGPHWRRALEPRALPYILQQHGYNTFFGGKYLNQYWGAGDVPKGWNHFYGLHGNSRYY 153
            |:.:  |..|.|:...|.|.....|...||.|.|.|||||:|.|: .||.||..:.||..|||:|
  Rat   109 NNEN--CSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYNGS-YVPPGWKEWVGLLKNSRFY 170

  Fly   154 NYTL-----RENSGNVHYESTYLTDLLRDRAADFLRNATQ--SSEPFFAMVAPPAAHEPFTPAPR 211
            ||||     :|..|: .|.:.|||||:.:.:..|.|.:.:  ...|...:::..|.|.|...||:
  Rat   171 NYTLCRNGMKEKHGS-DYSTDYLTDLITNDSVSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQ 234

  Fly   212 HEGVFSHIEALRTPSFNQV-KQDKHWLVR---AARRLPNETINTIDTYFQKRWETLLAVDELVVT 272
            :..:|.:.....|||:|.. ..||||::|   ..:.:..|..|.:.   :||.:||::||:.:.|
  Rat   235 YSRLFPNASQHITPSYNYAPNPDKHWIMRYTGPMKPIHMEFTNMLQ---RKRLQTLMSVDDSMET 296

  Fly   273 LMGVLNDTQSLENTYIIYTSDNGYHVGQFAQPFDKRQPYETDINVPLLIRGPGIAPESHIDTAVS 337
            :..:|.:|..|:||||:||:|:|||:|||.....|..|||.||.||..:|||.:...|.....|.
  Rat   297 IYDMLVETGELDNTYIVYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYVRGPSVEAGSLNPHIVL 361

  Fly   338 LVDLAPTILAWADIDTPSYMDGQSFHELLLNKRRRVPFFERSLLIEYWGEGTLATFNPECPWPEK 402
            .:|||||||..|.:|.|:.|||:|..: ||:..|.|..|.....:..|.:..|.         |:
  Rat   362 NIDLAPTILDIAGLDIPADMDGKSILK-LLDSERPVNRFHLKKKLRVWRDSFLV---------ER 416

  Fly   403 DRLAQCTPAADCHCQDAWNNTYACLRNIRHRE-DRIYCEFRDNENFLEAYDLQLDPFQMTNIAYD 466
            .:|                        :..|| |::..:   .||||..|....|..|
  Rat   417 GKL------------------------LHKREGDKVNAQ---EENFLPKYQRVKDLCQ------- 447

  Fly   467 LLPIERALYSLRLKNLTQ-------CSG----HSC 490
                 ||.|....:.|.|       .||    |.|
  Rat   448 -----RAEYQTACEQLGQKWQCVEDASGALKLHKC 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18278	NP_725289.1	G6S	24..467	CDD:293766	164/454 (36%)
CG18278	NP_725289.1	AslA	24..464	CDD:225661	164/451 (36%)
Sulf2	NP_001030099.1	G6S	43..385	CDD:293766	144/347 (41%)
		DUF3740	533..666	CDD:403667
		ALP_like	<754..803	CDD:419962
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351087
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1273622at2759
OrthoFinder	1	1.000	-	-		FOG0001009
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750