DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18278 and Gns

DIOPT Version :9

Sequence 1:	NP_725289.1	Gene:	CG18278 / 36487	FlyBaseID:	FBgn0033836	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	XP_006241458.1	Gene:	Gns / 299825	RGDID:	1305877	Length:	544	Species:	Rattus norvegicus

Alignment Length:	497	Identity:	226/497 - (45%)
Similarity:	303/497 - (60%)	Gaps:	21/497 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LIILVLACLGNTASEKLPNILLILSDDQDVELRGMFPMEHTIEMLGFGGALFHNAYTPSPICCPA 71
            |:.|:..|||...:.:.||:||:|:||||.||.||.|::.|..::|..|..|.:||.||.:|||:
  Rat    22 LLPLLSGCLGLVGAARRPNVLLLLTDDQDAELGGMTPLKKTKALIGEKGMTFSSAYVPSALCCPS 86

  Fly    72 RTSLLTGMYAHNHGTRNNSVSGGCYGPHWRRALEPRALPYILQ-QHGYNTFFGGKYLNQYWGAGD 135
            |.|:|||.|.|||...||::.|.|....|::..||...|.||: ..||.|||.|||||:| ||.|
  Rat    87 RASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPYTFPAILKLVCGYQTFFAGKYLNEY-GAPD 150

  Fly   136 ------VPKGWNHFYGLHGNSRYYNYTLRENS----GNVHYESTYLTDLLRDRAADFLRNATQSS 190
                  ||.||:::|.|..||:||||||..|.    ...:|...||||:|.:.:.||| :...:|
  Rat   151 AGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKARRHGENYSVDYLTDVLANLSLDFL-DYKSNS 214

  Fly   191 EPFFAMVAPPAAHEPFTPAPRHEGVFSHIEALRTPSFNQVKQDKHWLVRAARR-LPNETINTIDT 254
            ||||.|::.||.|.|:|.||:::..|.::.|.|..:||....:||||:|.|:. :.|.:|..:|.
  Rat   215 EPFFMMISTPAPHSPWTAAPQYQKAFPNVIAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIKFLDD 279

  Fly   255 YFQKRWETLLAVDELVVTLMGVLNDTQSLENTYIIYTSDNGYHVGQFAQPFDKRQPYETDINVPL 319
            .|::||:|||:||:||..|:..|:.|..|:||||.||||||||.|||:.|.||||.||.||.|||
  Rat   280 AFRRRWQTLLSVDDLVEKLVKRLDSTGELDNTYIFYTSDNGYHTGQFSLPIDKRQLYEFDIKVPL 344

  Fly   320 LIRGPGIAPESHIDTAVSLVDLAPTILAWADID-TPSYMDGQSFHELLLNKRRRVPFFERSLLIE 383
            |:|||||.|.......||.:||.||||..|..| ..:.|||.|...:|.......  :...:|:|
  Rat   345 LVRGPGIKPNQTSKMLVSNIDLGPTILDLAGYDLNKTQMDGTSLLPILKGDGNLT--WRSDVLVE 407

  Fly   384 YWGEGTLATFNPECPWPEKDRLAQCTPAADCHCQDAWNNTYACLRNIRHREDRIYCEFRDNENFL 448
            |.|||...| :|.|| .....::||.|  ||.|:||:||||||:|.:....:..||||.|.|.|:
  Rat   408 YQGEGRNVT-DPTCP-SLSPGVSQCFP--DCVCEDAYNNTYACVRTLSSMWNLQYCEFDDQEVFV 468

  Fly   449 EAYDLQLDPFQMTNIAYDLLPIERALYSLRLKNLTQCSGHSC 490
            |.|::..||.|:||||..:.|......:.||..|..|||.:|
  Rat   469 EVYNITADPDQITNIAKSIDPELLGKMNYRLMMLQSCSGPTC 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18278	NP_725289.1	G6S	24..467	CDD:293766	213/455 (47%)
CG18278	NP_725289.1	AslA	24..464	CDD:225661	211/452 (47%)
Gns	XP_006241458.1	G6S	38..487	CDD:293766	213/456 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351099
Domainoid	1	1.000	320	1.000	Domainoid score	I1203
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1568
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1808
OMA	1	1.010	-	-		QHG57985
OrthoDB	1	1.010	-	-		D1273622at2759
OrthoFinder	1	1.000	-	-		FOG0001009
OrthoInspector	1	1.000	-	-		oto98726
orthoMCL	1	0.900	-	-		OOG6_103483
Panther	1	1.100	-	-	O	PTHR43108
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5154
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810