DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18278 and Arsj

DIOPT Version :9

Sequence 1:	NP_725289.1	Gene:	CG18278 / 36487	FlyBaseID:	FBgn0033836	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_775627.1	Gene:	Arsj / 271970	MGIID:	2443513	Length:	598	Species:	Mus musculus

Alignment Length:	542	Identity:	119/542 - (21%)
Similarity:	195/542 - (35%)	Gaps:	161/542 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 TASEKLPNILLILSDDQ---DVELRGMFPMEHTIEMLGFGGALFHNAYTPSPICCPARTSLLTGM 79
            ||....|:::.||:|||   ||...|......|::.|...|....|.|. .|||.|:|:..:||.
Mouse    68 TAGTSQPHLIFILADDQGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYV-QPICTPSRSQFITGK 131

  Fly    80 YAHNHGTRNNSV---SGGCYGPHWRRALEPRALPYILQQHGYNTFFGGKYLNQYWGAGDVP--KG 139
            |..:.|.:::.:   ...|.      .|:...||..|::.||:|...||:...::....:|  :|
Mouse   132 YQIHTGLQHSIIRPTQPNCL------PLDNATLPQKLKEVGYSTHMVGKWHLGFYRKDCMPTKRG 190

  Fly   140 WNHFYG-LHGNSRYY-----------NYTLRENSGNVHYE---STYLTDLLRDRAADFLRNATQS 189
            ::.|:| |.|:..||           .|.|.||. |..::   ..|.|.:...|....|  ||..
Mouse   191 FDTFFGSLLGSGDYYTHYKCDSPGVCGYDLYEND-NAAWDYDNGIYSTQMYTQRVQQIL--ATHD 252

  Fly   190 -SEPFFAMVAPPAAHEPFTPAPRHEGVFSHIEALRTPSFNQVKQDKHWLVRAARRLPNETINTID 253
             ::|.|..||..|.|.|.....|:   |.|..::                        ..||
Mouse   253 PTKPLFLYVAYQAVHSPLQAPGRY---FEHYRSI------------------------ININ--- 287

  Fly   254 TYFQKRWETLLA-VDELVVTLMGVLNDTQSLENTYIIYTSDNGYHVGQFAQPFDKRQPYETDINV 317
               ::|:..:|: :||.:..:...|.......|:.|||:||||            .||.....|.
Mouse   288 ---RRRYAAMLSCLDEAIHNVTLALKRYGFYNNSIIIYSSDNG------------GQPTAGGSNW 337

  Fly   318 PLLIRGP-------GIAPESHIDT------------AVSLVDLAPTILAWAD--IDTPSYMDGQS 361
            ||  ||.       ||.....:.:            .|.:.|..||:::.|:  ||....:||..
Mouse   338 PL--RGSKGTYWEGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQLDGYD 400

  Fly   362 FHELLLNKRR--RV-------PFF-------------------ERSLLIEYWGEGTLATFNP-EC 397
            ..|.:....|  ||       |.:                   :.::.:::|   .|.|.|| ..
Mouse   401 IWETISEGLRSPRVDILHNIDPIYTKAKNGSWAAGYGIWNTAIQSAIRVQHW---KLLTGNPGYS 462

  Fly   398 PWPEKDRLAQCTPAADCHCQDAWNNTYACLRNIRHREDRIYCEFRDNENFLEAYDLQLDPFQMTN 462
            .|......:...|       :.|:|....|               .....:..:::..||::..:
Mouse   463 DWVPPQAFSNLGP-------NRWHNERITL---------------STGKSIWLFNITADPYERVD 505

  Fly   463 IAYDLLPIERALYSLRLKNLTQ 484
            ::.....|.:.|    |:.|:|
Mouse   506 LSSRYPGIVKKL----LRRLSQ 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18278	NP_725289.1	G6S	24..467	CDD:293766	112/517 (22%)
CG18278	NP_725289.1	AslA	24..464	CDD:225661	112/514 (22%)
Arsj	NP_775627.1	AslA	71..507	CDD:225661	112/517 (22%)
		4-S	74..507	CDD:293753	112/514 (22%)
		DUF4976	<493..>531	CDD:303608	7/35 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..598
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847564
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740