DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh31-R and Glp2r

DIOPT Version :9

Sequence 1:	NP_001260951.1	Gene:	Dh31-R / 36475	FlyBaseID:	FBgn0052843	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_783612.2	Gene:	Glp2r / 93896	MGIID:	2136733	Length:	512	Species:	Mus musculus

Alignment Length:	383	Identity:	102/383 - (26%)
Similarity:	178/383 - (46%)	Gaps:	58/383 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 AGTHCAGTFDGWLCWPDTAVGTSAYELCPDFITGFD---PARYAHKECGLDGEWFKHPLTNKTWS 125
            :|..|.||||.::|||.:..|..:.. ||.::..::   |.| |::.|...|.|.|...:..||.
Mouse    52 SGVFCNGTFDKYVCWPHSFPGNVSVP-CPSYLPWWNKESPGR-AYRHCLAQGTWQKQENSTDTWQ 114

  Fly   126 NYTTC-------VNLEDLNWRH----TVNLISEVGYGTSLLAILLSLAILGYFKSLKCARITLHM 179
            :.:.|       .|::  ::.|    |:.|:..|||..||:::.|:|.:..:.:.|.|.|..:||
Mouse   115 DESECSENHSFKQNVD--HYHHTLLSTLQLMYTVGYSLSLISLFLALTLFLFLRKLHCTRNYIHM 177

  Fly   180 NLFASFAANNSLWLVWYLLV------MPNSE-----LLHQSPMRCVALHITLHYFLLSNYSWMLC 233
            ||||||.....:.||..::.      .|:||     .|.:....|.::.:.||||:.:|:.|:|.
Mouse   178 NLFASFILRALVVLVKDMVFYNSYSRRPDSESGWMSYLSEISASCRSVQVLLHYFVGTNHLWLLV 242

  Fly   234 EGFYLHTVLVAAFISEKRLVKWLIAFGWGSPAIVIFVYSMARGLGGTPEDNRHCWMNQTNYQN-- 296
            ||.|||.:|....:.|:||....:..||..|.:.:..:...|    ...:|..||....|.:.
Mouse   243 EGLYLHALLEPTVLPERRLWPKYLVVGWAFPMLFVIPWIFVR----ASLENTGCWAVNENKKIWW 303

  Fly   297 ILMVPVCISMFLNLLFLCNIVRVVLLKLNAPASIQGSCGPSRTVLQAFR--------ATLLLVPL 353
            |:..|:.:.:.:|......|:::::.|..|..             ..||        :||||:.|
Mouse   304 IIRGPILLCVTVNFFIFLKILKLLISKFRAHQ-------------MCFRDYKYRLAKSTLLLILL 355

  Fly   354 LGL-QYILTPFRPAPKHPWENTYEIISAFT-ASFQGLCVAILFCFCNGEVIAQMKRKW 409
            :|: :::.|.|.......:.....:....| :||.|..||:.:.|.:.||.|::::.|
Mouse   356 MGVHEFLFTFFTDDQVQGFSRLIRLFIQLTLSSFHGFLVALQYGFASREVKAELRKTW 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh31-R	NP_001260951.1	HRM	65..132	CDD:280888	22/76 (29%)
Dh31-R	NP_001260951.1	7tm_4	140..390	CDD:304433	72/276 (26%)
Glp2r	NP_783612.2	HRM	53..122	CDD:280888	22/70 (31%)
		7tm_2	137..394	CDD:278432	71/273 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..494
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810