Protein Alignment Dh31-R and GLP2R

DIOPT Version :10

• Sequence 1: NP_001260951.1
• Gene: Dh31-R / 36475
• FlyBaseID: FBgn0052843
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: XP_011522379.1
• Gene: GLP2R / 9340
• HGNCID: 4325
• Length: 578
• Species: Homo sapiens
• Alignment Length: 407
• Identity: 111/407 - (27%)
• Similarity: 182/407 - (44%)
• Gaps: 83/407 - (20%)

  Fly    64 AGTHCAGTFDGWLCWPDTAVGTSAYELCPDF---------------------ITGF------DPA 101
            :|..|.||||.::|||.::.|..:.. ||.:                     |:|:      :.:
Human    92 SGIFCNGTFDQYVCWPHSSPGNVSVP-CPSYLPWWSEDHQQIQGQLKLFSGKISGYKLQAKQESS 155

  Fly   102 RYAHKECGLDGEWFKHPLTNKT--WSNYTTC-------VNLEDLNWRHTVNLISEVGYGTSLLAI 157
            ..|::.|...|.|  ..:.|.|  |.:.:.|       .|::......|:.|:..|||..||:::
Human   156 GRAYRHCLAQGTW--QTIENATDIWQDDSECSENHSFKQNVDRYALLSTLQLMYTVGYSFSLISL 218

  Fly   158 LLSLAILGYFKSLKCARITLHMNLFASFAANNSLWLVWYLLV------MPNSE-----LLHQSPM 211
            .|:|.:|.:.:.|.|.|..:||||||||.......||..::.      .|::|     .|.:...
Human   219 FLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENGWMSYLSEMST 283

  Fly   212 RCVALHITLHYFLLSNYSWMLCEGFYLHTVLVAAFISEKRLVKWLIAFGWGSPAIVIFVYSMARG 276
            .|.::.:.||||:.:||.|:|.||.||||:|....:.|:||....:..||..|.:.:..:..||
Human   284 SCRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLGWAFPVLFVVPWGFAR- 347

  Fly   277 LGGTPEDNRHCWMNQTNYQN--ILMVPVCISMFLNLLFLCNIVRVVLLKLNAPASIQGSCGPSRT 339
               ...:|..||....|.:.  |:..|:.:.:.:|......|:::::.||.|..
Human   348 ---AHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLISKLKAHQ----------- 398

  Fly   340 VLQAFR--------ATLLLVPLLGLQYILTPFRPAPKHPWENTYEIISAF----TASFQGLCVAI 392
              ..||        :||:|:||||:..||..|  ......|...::|..|    .:||.|..||:
Human   399 --MCFRDYKYRLAKSTLVLIPLLGVHEILFSF--ITDDQVEGFAKLIRLFIQLTLSSFHGFLVAL 459

  Fly   393 LFCFCNGEVIAQMKRKW 409
            .:.|.||||.|::::.|
Human   460 QYGFANGEVKAELRKYW 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dh31-R	NP_001260951.1	HRM	65..132	CDD:397086	22/102 (22%)
		7tmB1_NPR_B4_insect-like	139..411	CDD:320388	88/296 (30%)
		TM helix 1	141..166	CDD:320388	10/24 (42%)
		TM helix 2	175..197	CDD:320388	10/21 (48%)
		TM helix 3	214..241	CDD:320388	13/26 (50%)
		TM helix 4	253..273	CDD:320388	3/19 (16%)
		TM helix 5	291..320	CDD:320388	5/30 (17%)
		TM helix 6	339..366	CDD:320388	12/34 (35%)
		TM helix 7	373..398	CDD:320388	8/28 (29%)
GLP2R	XP_011522379.1	HRM	93..187	CDD:397086	22/96 (23%)
		7tmB1_GLP2R	200..478	CDD:320394	88/296 (30%)
		TM helix 1	202..227	CDD:320394	10/24 (42%)
		TM helix 2	236..258	CDD:320394	10/21 (48%)
		TM helix 3	286..313	CDD:320394	13/26 (50%)
		TM helix 4	325..345	CDD:320394	3/19 (16%)
		TM helix 5	361..390	CDD:320394	5/28 (18%)
		TM helix 6	404..431	CDD:320394	10/28 (36%)
		TM helix 7	440..465	CDD:320394	8/24 (33%)