DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh31-R and Sctr

DIOPT Version :9

Sequence 1:	NP_001260951.1	Gene:	Dh31-R / 36475	FlyBaseID:	FBgn0052843	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_038947043.1	Gene:	Sctr / 81779	RGDID:	621342	Length:	464	Species:	Rattus norvegicus

Alignment Length:	478	Identity:	137/478 - (28%)
Similarity:	220/478 - (46%)	Gaps:	92/478 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 DALRAACETRLNASGQLA----GSGGPGAE--------AGTH-----CAGTFDGWLCWPDTAVGT 85
            |..|...|.|.:...||:    |:.||...        |.:|     |.|.:|...|||.:|...
  Rat    34 DVRRVLLEERAHCLQQLSKEKKGALGPETASASVFSPFASSHAVYQGCEGLWDNMSCWPSSAPAR 98

  Fly    86 SAYELCPDFITGFDPARYA-HKECGLDG--EWFKHPLTNKTWSNYTTCVNLED-LNWRHTVNLIS 146
            :....||.|:........: .:.|..||  |.|..|       :....||:.: .|.|....|:.
  Rat    99 TVEVQCPKFLLMLSNKNGSLFRNCTQDGWSETFPRP-------DLACGVNINNSFNERRHAYLLK 156

  Fly   147 -----EVGYGTSLLAILLSLAILGYFKSLKCARITLHMNLFASFAANNSLWLVWYLLVMPNSELL 206
                 .|||.:||..:|::|:||..|:.|.|.|..:||:||.||........:...::..:.::.
  Rat   157 LKVMYTVGYSSSLAMLLVALSILCSFRRLHCTRNYIHMHLFVSFILRALSNFIKDAVLFSSDDVT 221

  Fly   207 H--QSPMRCVALHITLHYFLLSNYSWMLCEGFYLHTVLVAAFISEKRLVKWLIAFGWGSPAIVIF 269
            :  ...:.|..:.|...|.:::||:|:|.||.||||:|..:|.||::.::..:..|||||||.:.
  Rat   222 YCDAHKVGCKLVMIFFQYCIMANYAWLLVEGLYLHTLLAISFFSERKYLQAFVLLGWGSPAIFVA 286

  Fly   270 VYSMARGLGGTPEDNRHCWMNQTNYQN--ILMVPVCISMFLNLLFLCNIVRVVLLKLNAPASIQG 332
            ::::.|..    .:|..||....|...  ::..||.:|:.:|.:|..||:|:::.||....: :|
  Rat   287 LWAITRHF----LENTGCWDINANASVWWVIRGPVILSILINFIFFINILRILMRKLRTQET-RG 346

  Fly   333 SCGPSRTVLQAFRATLLLVPLLGLQYILTPFRPAPKHPWENTYEIISAF---TASFQGLCVAILF 394
            |  .:....:..::||||:||.|:.||:..|.|      |:..|:...|   ..|||||.||:|:
  Rat   347 S--ETNHYKRLAKSTLLLIPLFGIHYIVFAFSP------EDAMEVQLFFELALGSFQGLVVAVLY 403

  Fly   395 CFCNGEVIAQMKRKWR---MMCFSNRP--RTNSYTATQVSFVRCGPPLPGEEKVXLKDMSAKRRA 454
            ||.||||..::::|||   :..|..||  ..||::                            .|
  Rat   404 CFLNGEVQLEVQKKWRQWHLQEFPLRPVAFNNSFS----------------------------NA 440

  Fly   455 SAGPQHHQPHHQSHQLSTDQQRA 477
            :.||.|      |.:.||:|.|:
  Rat   441 TNGPTH------STKASTEQSRS 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh31-R	NP_001260951.1	HRM	65..132	CDD:280888	17/74 (23%)
Dh31-R	NP_001260951.1	7tm_4	140..390	CDD:304433	80/261 (31%)
Sctr	XP_038947043.1	HormR	80..147	CDD:214468	18/73 (25%)
		7tmB1_secretin	154..420	CDD:320403	91/278 (33%)
		TM helix 1	157..181	CDD:320403	9/23 (39%)
		TM helix 2	190..211	CDD:320403	6/20 (30%)
		TM helix 3	231..253	CDD:320403	7/21 (33%)
		TM helix 4	272..288	CDD:320403	7/15 (47%)
		TM helix 5	306..329	CDD:320403	6/22 (27%)
		TM helix 6	356..378	CDD:320403	11/27 (41%)
		TM helix 7	382..407	CDD:320403	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810