DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh31-R and adcyap1r1

DIOPT Version :9

Sequence 1:	NP_001260951.1	Gene:	Dh31-R / 36475	FlyBaseID:	FBgn0052843	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_031759329.1	Gene:	adcyap1r1 / 780260	XenbaseID:	XB-GENE-5805848	Length:	503	Species:	Xenopus tropicalis

Alignment Length:	499	Identity:	132/499 - (26%)
Similarity:	206/499 - (41%)	Gaps:	133/499 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 PGAEAGTHCAGTFDGWLCWPDTAVGTSAYELCP------------DFI---TGFDP--------A 101
            ||      |.|.:|...||....||......||            ||:   .|:.|        |
Frog    51 PG------CPGMWDNITCWMPAEVGKVVSIRCPALFSMLGSEDEMDFVDRSLGWAPENLEEQQSA 109

  Fly   102 RYAHKECGLDGEWFKHPLTNKTWSNYTTCVNLEDLN--------WRHTVNLISEVGYGTSLLAIL 158
            ....:.|..:| |..|      :.:|:...:. |:|        :..:|..:..|||.|||:|:.
Frog   110 GIITRNCTENG-WTDH------FPHYSEACDF-DINETGPDQDTYYLSVKALYTVGYSTSLVALT 166

  Fly   159 LSLAILGYFKSLKCARITLHMNLFASFAANNSLWLVWYLLVMPNSELL---------HQSPMRCV 214
            .::.||..|:.|.|.|..:|||||.||       ::..:.|....|:|         |.|.:.|.
Frog   167 TAMVILCRFRKLHCTRNFIHMNLFVSF-------ILRAISVFIKDEVLYAEQDSNHCHLSTVECK 224

  Fly   215 ALHITLHYFLLSNYSWMLCEGFYLHTVLVAAFISEKRLVKWLIAFGWGSPAIVIFVYSMARGLGG 279
            .:.:..||.::|||.|:..||.||.|:||..|..|:|...|....|||:|.|.:.::::.|
Frog   225 VVMVFFHYCVMSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPLICVTIWAVLR---- 285

  Fly   280 TPEDNRHCWMNQTNYQN--ILMVPVCISMFLNLLFLCNIVRVVLLKLNAP------ASIQGSCGP 336
            ...|:..||....|:..  ::..||..|:.:|.:....|:.:::.||.:|      :||..||..
Frog   286 LHFDDVGCWDMNDNFALWWVIKGPVIGSIMINFVLFVGIIIILVQKLQSPDIGGNESSIYFSCFQ 350

  Fly   337 -------------------SRTVLQAFRATLLLVPLLGLQYILTPFRPAPKHPWENTYE----II 378
                               |...|:..|:||||:||.|:.|.:..|.|      ||..:    :.
Frog   351 KCFCKTKRANEHSFKMSELSIITLRLARSTLLLIPLFGIHYTVFAFSP------ENVSKRERLVF 409

  Fly   379 SAFTASFQGLCVAILFCFCNGEVIAQ--MKRKWRMMCFSNRPRTNSYTATQVSFVRCG----PPL 437
            .....||||..||||:||.|||.:.:  ::.|..|....::|           .:.||    |.:
Frog   410 ELGLGSFQGFVVAILYCFLNGEFLPKGAIRNKEEMEELESQP-----------VLCCGFQTPPSV 463

  Fly   438 PGEEKVXLKDMSAKRRASAGPQHHQPHHQSHQLS-TDQQRARSQ 480
            .||::...:|.:.             |.:..||: :|.|..|.:
Frog   464 SGEQRSERRDTTV-------------HSEQEQLTDSDVQHKRRE 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh31-R	NP_001260951.1	HRM	65..132	CDD:280888	19/89 (21%)
Dh31-R	NP_001260951.1	7tm_4	140..390	CDD:304433	85/289 (29%)
adcyap1r1	XP_031759329.1	HRM	50..135	CDD:397086	21/97 (22%)
		7tm_GPCRs	147..431	CDD:421689	92/300 (31%)
		TM helix 1	149..174	CDD:410628	10/24 (42%)
		TM helix 2	183..205	CDD:410628	8/28 (29%)
		TM helix 3	224..251	CDD:410628	10/26 (38%)
		TM helix 4	263..283	CDD:410628	6/19 (32%)
		TM helix 5	299..328	CDD:410628	6/28 (21%)
		TM helix 6	344..399	CDD:410628	16/60 (27%)
		TM helix 7	404..429	CDD:410628	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000