Protein Alignment Dh31-R and VIPR2

DIOPT Version :10

• Sequence 1: NP_001260951.1
• Gene: Dh31-R / 36475
• FlyBaseID: FBgn0052843
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: NP_003373.2
• Gene: VIPR2 / 7434
• HGNCID: 12695
• Length: 438
• Species: Homo sapiens
• Alignment Length: 384
• Identity: 115/384 - (29%)
• Similarity: 183/384 - (47%)
• Gaps: 38/384 - (9%)

  Fly    68 CAGTFDGWLCWPDTAVGTSAYELCPDFITGF-DPARYAHKECGLDGEWFKHPLTNKTWSNYTTCV 131
            |:|.:|...||....||.:....||...:.| ..|....|.|..|| |      ::|:.::....
Human    52 CSGVWDNITCWRPANVGETVTVPCPKVFSNFYSKAGNISKNCTSDG-W------SETFPDFVDAC 109

  Fly   132 NLED------LNWRHTVNLISEVGYGTSLLAILLSLAILGYFKSLKCARITLHMNLFASFAANNS 190
            ...|      :.:...|..|..:||..||:::.....||..|:.|.|.|..:|:|||.||.....
Human   110 GYSDPEDESKITFYILVKAIYTLGYSVSLMSLATGSIILCLFRKLHCTRNYIHLNLFLSFILRAI 174

  Fly   191 LWLVWYLLVMPNSELLH-----QSPMRCVALHITLHYFLLSNYSWMLCEGFYLHTVLVAAFISEK 250
            ..||...::..:|..||     .|.:.|....:.|.|.:::|:.|:|.||.||||:|||.....:
Human   175 SVLVKDDVLYSSSGTLHCPDQPSSWVGCKLSLVFLQYCIMANFFWLLVEGLYLHTLLVAMLPPRR 239

  Fly   251 RLVKWLIAFGWGSPAIVIFVYSMARGLGGTPEDNRHCWMNQTNYQN----ILMVPVCISMFLNLL 311
            ..:.:|: .|||.|.:.|..::.||    ...::..||  .||..:    ::.:|:.||:.:|.:
Human   240 CFLAYLL-IGWGLPTVCIGAWTAAR----LYLEDTGCW--DTNDHSVPWWVIRIPILISIIVNFV 297

  Fly   312 FLCNIVRVVLLKLNAPASIQGSCGPSRTVLQAFRATLLLVPLLGLQYILTPFRPAPKHPWENTYE 376
            ...:|:|::|.||.:| .:.|:  ......:..::||||:||.|:.|::....|.   ...:.|:
Human   298 LFISIIRILLQKLTSP-DVGGN--DQSQYKRLAKSTLLLIPLFGVHYMVFAVFPI---SISSKYQ 356

  Fly   377 II-SAFTASFQGLCVAILFCFCNGEVIAQMKRKWRMMCFSNRPRTNSYTATQVSFVRCG 434
            |: .....|||||.||:|:||.|.||..::|||||..| .....:..|.....||.|.|
Human   357 ILFELCLGSFQGLVVAVLYCFLNSEVQCELKRKWRSRC-PTPSASRDYRVCGSSFSRNG 414

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dh31-R	NP_001260951.1	HRM	65..132	CDD:397086	17/64 (27%)
		7tmB1_NPR_B4_insect-like	139..411	CDD:320388	90/281 (32%)
		TM helix 1	141..166	CDD:320388	8/24 (33%)
		TM helix 2	175..197	CDD:320388	8/21 (38%)
		TM helix 3	214..241	CDD:320388	10/26 (38%)
		TM helix 4	253..273	CDD:320388	6/19 (32%)
		TM helix 5	291..320	CDD:320388	8/32 (25%)
		TM helix 6	339..366	CDD:320388	8/26 (31%)
		TM helix 7	373..398	CDD:320388	12/25 (48%)
VIPR2	NP_003373.2	HormR	52..118	CDD:214468	18/72 (25%)
		7tmB1_VIP-R2	123..392	CDD:320652	90/281 (32%)
		TM helix 1	125..150	CDD:320652	8/24 (33%)
		TM helix 2	159..181	CDD:320652	8/21 (38%)
		TM helix 3	203..230	CDD:320652	10/26 (38%)
		TM helix 4	241..261	CDD:320652	6/20 (30%)
		TM helix 5	277..306	CDD:320652	6/28 (21%)
		TM helix 6	322..349	CDD:320652	8/26 (31%)
		TM helix 7	354..379	CDD:320652	12/24 (50%)