DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh31-R and gcgra

DIOPT Version :9

Sequence 1:	NP_001260951.1	Gene:	Dh31-R / 36475	FlyBaseID:	FBgn0052843	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_009298002.1	Gene:	gcgra / 562973	ZFINID:	ZDB-GENE-050516-1	Length:	520	Species:	Danio rerio

Alignment Length:	444	Identity:	129/444 - (29%)
Similarity:	202/444 - (45%)	Gaps:	83/444 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 GTHCAGTFDGWLCWPDTAVGTSAYELCPDFITGFDPARY--AHKECGLDGEWFKHPLTNKTWSNY 127
            |..|..|||.:.||||....|:....||.::......|:  .|.||..||::.|.       .:.
Zfish    51 GVVCNRTFDRYACWPDALPNTTVSVACPWYLPWHKEVRHGLVHVECDADGQYSKQ-------KDA 108

  Fly   128 TTCVNLEDLNWRHTVNLISE------VGYGTSLLAILLSLAILGYFKSLKCARITLHMNLFASFA 186
            :.|::.:  |.:|...::.:      |||..||.|::|:|:||..|:.|.|.|..:||||||||.
Zfish   109 SECLSRD--NIQHYGRILRQFRTMYTVGYSLSLGALVLALSILVAFRKLHCMRNNIHMNLFASFI 171

  Fly   187 ANNSLWLVWYLL-----VMP-----NSEL------LHQSPMRCVALHITLHYFLLSNYSWMLCEG 235
            ...|..|:...|     ..|     .:||      .:::.:.|....:.:.|.:|:|..|:|.||
Zfish   172 LRASSILIKDALSERPDTFPVGQDITTELEVEWLVKNETAVGCRVAVVMMQYSILANSYWLLVEG 236

  Fly   236 FYLHTVLVAAFISEKRLVKWLIAFGWGSPAIVIFVYSMARGLGGTPEDNRHCW--MNQTNYQNIL 298
            .|||::||...::|:..:...::.|||:|.|.:..:.:.:.|    .:|..||  .|...|..|:
Zfish   237 IYLHSLLVVTVLTERNYLSIYLSIGWGAPLIFVLPWVIVKYL----YENEECWEQNNHMEYWWII 297

  Fly   299 MVPVCISMFLNLLFLCNIVRVVLLKLNAPASIQGSCGPSRTVLQAFRATLLLVPLLGLQYILTPF 363
            ..|:.:::.:|.....:|:::::.||.|     .....|....:..::||.|:||||:..:|..|
Zfish   298 RSPILLAVLINFFIFIHIIKILVSKLRA-----HQMRYSDYKFRLAKSTLTLIPLLGIHSVLFSF 357

  Fly   364 --RPAPKH---PWENTYEIISAFTASFQGLCVAILFCFCNGEVIAQMKRKWR------------- 410
              ..:..|   |...|...|..|..|||||.||||:||.|.||.:::.:|||
Zfish   358 VTDESTSHGALPLRLTKLFIDLFFNSFQGLLVAILYCFVNKEVQSEILKKWRRWKLGRDIEEEYR 422

  Fly   411 ---------------MMCFSNRPRTNSYTATQVSFVRCGPPLPGEEKVXLKDMS 449
                           |:..:|.||... .||..|  |.|.|   |||..|...|
Zfish   423 HTYSQSLQIQKSGSIMVHPTNLPRLPD-IATTTS--RLGSP---EEKQMLVSSS 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh31-R	NP_001260951.1	HRM	65..132	CDD:280888	20/68 (29%)
Dh31-R	NP_001260951.1	7tm_4	140..390	CDD:304433	81/278 (29%)
gcgra	XP_009298002.1	HRM	51..113	CDD:308439	20/68 (29%)
		7tm_GPCRs	124..410	CDD:333717	91/294 (31%)
		TM helix 1	127..151	CDD:320095	10/23 (43%)
		TM helix 2	160..181	CDD:320095	10/20 (50%)
		TM helix 3	215..237	CDD:320095	6/21 (29%)
		TM helix 4	256..272	CDD:320095	5/15 (33%)
		TM helix 5	290..313	CDD:320095	4/22 (18%)
		TM helix 6	335..360	CDD:320095	9/24 (38%)
		TM helix 7	372..397	CDD:320095	14/24 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910