DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh31-R and calcrl

DIOPT Version :9

Sequence 1:	NP_001260951.1	Gene:	Dh31-R / 36475	FlyBaseID:	FBgn0052843	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_012825895.1	Gene:	calcrl / 549647	XenbaseID:	XB-GENE-5736126	Length:	481	Species:	Xenopus tropicalis

Alignment Length:	380	Identity:	147/380 - (38%)
Similarity:	222/380 - (58%)	Gaps:	23/380 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 GTHCAGTFDGWLCWPDTAVGTSAYELCPDFITGFDPARYAHKECGLDGEWFKHPLTNKTWSNYTT 129
            |..|..|:||||||.|.:.|..:.:.|||:...|||:....||||.:|.||:||.:|:||:|||.
Frog    81 GHFCNRTWDGWLCWGDVSAGVISEQRCPDYFQDFDPSEKVTKECGKNGHWFRHPDSNRTWTNYTR 145

  Fly   130 CVNLEDLNWRHTVNL--ISEVGYGTSLLAILLSLAILGYFKSLKCARITLHMNLFASFAANNSLW 192
            |........:..:||  ::.:|:|.|:.::|:||.|..|||:|.|.|||||.|||.||..|:.:.
Frog   146 CNTFTHEKVKTALNLYYLTIIGHGLSIASLLISLGIFFYFKNLSCQRITLHKNLFFSFVCNSIIT 210

  Fly   193 LVWYLLVMPNSELLHQSPMRCVALHITLHYFLLS-NYSWMLCEGFYLHTVLVAAFISEKRLVKWL 256
            ::....|..|..|:..:|:.| .:...:|.:|:. ||.||||||.||||::|.|..:||:.:.|.
Frog   211 IISLSAVANNQALVATNPVSC-KISQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWY 274

  Fly   257 IAFGWGSPAIVIFVYSMARGLGGTPEDNRHCWM-NQTNYQNILMVPVCISMFLNLLFLCNIVRVV 320
            ...|||.|.|...::::||.|    ..|.:||: ::|:...|:..|:|.::.:||.||.|||||:
Frog   275 YLLGWGFPLIPACIHAVARSL----YYNDNCWISSETHLLYIIHGPICAALLVNLFFLLNIVRVL 335

  Fly   321 LLKLNAPASIQGSCGPSRTVLQAFRATLLLVPLLGLQYILTPFRPAPKHPWENTYEIISAFTASF 385
            :.||......:     |...::|.||||:||||||::::|.|::|..:.. |..|:.:......:
Frog   336 ITKLKVTHQAE-----SNLYMKAVRATLILVPLLGIEFVLFPWKPEGRIA-EEIYDYVMHILMHY 394

  Fly   386 QGLCVAILFCFCNGEVIAQMKRKWRM--------MCFSNRPRTNSYTATQVSFVR 432
            |||.||.:|||.||||.|.:||.|..        ...|...|:.|||.:.:|.::
Frog   395 QGLLVATIFCFFNGEVQAVLKRHWNQYKIQFGSSFAHSEGLRSASYTVSSISEIQ 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh31-R	NP_001260951.1	HRM	65..132	CDD:280888	33/66 (50%)
Dh31-R	NP_001260951.1	7tm_4	140..390	CDD:304433	95/253 (38%)
calcrl	XP_012825895.1	HRM	81..149	CDD:367186	33/67 (49%)
		7tmB1_calcitonin_R	157..429	CDD:341343	108/282 (38%)
		TM helix 1	159..184	CDD:341343	9/24 (38%)
		TM helix 2	193..215	CDD:341343	10/21 (48%)
		TM helix 3	232..259	CDD:341343	13/26 (50%)
		TM helix 4	271..291	CDD:341343	6/19 (32%)
		TM helix 5	306..335	CDD:341343	12/28 (43%)
		TM helix 6	349..376	CDD:341343	13/26 (50%)
		TM helix 7	382..407	CDD:341343	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3583
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21179
Inparanoid	1	1.050	286	1.000	Inparanoid score	I2781
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1005634at2759
OrthoFinder	1	1.000	-	-		FOG0001436
OrthoInspector	1	1.000	-	-		mtm9427
Panther	1	1.100	-	-	O	PTHR45620
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2715
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.100