DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh31-R and Calcrl

DIOPT Version :9

Sequence 1:	NP_001260951.1	Gene:	Dh31-R / 36475	FlyBaseID:	FBgn0052843	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_061252.2	Gene:	Calcrl / 54598	MGIID:	1926944	Length:	463	Species:	Mus musculus

Alignment Length:	405	Identity:	156/405 - (38%)
Similarity:	230/405 - (56%)	Gaps:	34/405 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 GTHCAGTFDGWLCWPDTAVGTSAYELCPDFITGFDPARYAHKECGLDGEWFKHPLTNKTWSNYTT 129
            |.:|..|:||||||.|.|.||.:.:.|||:...|||:....|.|..||.||:||.:|:||:|||.
Mouse    61 GLYCNRTWDGWLCWNDVAAGTESMQYCPDYFQDFDPSEKVTKICDQDGHWFRHPDSNRTWTNYTL 125

  Fly   130 CVNLEDLNWRHTVNL--ISEVGYGTSLLAILLSLAILGYFKSLKCARITLHMNLFASFAANNSLW 192
            |.|......:..:||  ::.:|:|.|:.::::||.|..|||||.|.|||||.|||.||..|:.:.
Mouse   126 CNNSTHEKVKTALNLFYLTIIGHGLSIASLIISLIIFFYFKSLSCQRITLHKNLFFSFICNSIVT 190

  Fly   193 LVWYLLVMPNSELLHQSPMRCVALHITLHYFLLS-NYSWMLCEGFYLHTVLVAAFISEKRLVKWL 256
            ::....|..|..|:..:|:.|..... :|.:|:. ||.||||||.||||::|.|..:||:.:.|.
Mouse   191 IIHLTAVANNQALVATNPVSCKVSQF-IHLYLMGCNYFWMLCEGVYLHTLIVVAVFAEKQHLMWY 254

  Fly   257 IAFGWGSPAIVIFVYSMARGLGGTPEDNRHCWM-NQTNYQNILMVPVCISMFLNLLFLCNIVRVV 320
            ...|||.|.:...::::||.|    ..|.:||: :.|:...|:..|:|.::.:||.||.|||||:
Mouse   255 YFLGWGFPLLPACIHAIARSL----YYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVL 315

  Fly   321 LLKLNAPASIQGSCGPSRTVLQAFRATLLLVPLLGLQYILTPFRPAPKHPWENTYEIISAFTASF 385
            :.||.....::     |...::|.||||:||||||::::|.|:||..|.. |..|:.:......|
Mouse   316 ITKLKVTHQVE-----SNLYMKAVRATLILVPLLGIEFVLFPWRPEGKVA-EEVYDYVMHILMHF 374

  Fly   386 QGLCVAILFCFCNGEVIAQMKRKWRM--------MCFSNRPRTNSYTATQVSFVR-----C---- 433
            |||.||.:|||.||||.|.::|.|..        ...|:..|:.|||.:.:|.::     |
Mouse   375 QGLLVATIFCFFNGEVQAILRRNWNQYKIQFGNGFSHSDALRSASYTVSTISDMQGYSHDCPTEH 439

  Fly   434 --GPPLPGEEKVXLK 446
              |..:...|.| ||
Mouse   440 LNGKSIQDIENVALK 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh31-R	NP_001260951.1	HRM	65..132	CDD:280888	34/66 (52%)
Dh31-R	NP_001260951.1	7tm_4	140..390	CDD:304433	97/253 (38%)
Calcrl	NP_061252.2	HRM	61..128	CDD:397086	34/66 (52%)
		7tmB1_calcitonin_R	137..410	CDD:341343	109/283 (39%)
		TM helix 1	140..164	CDD:341343	7/23 (30%)
		TM helix 2	173..194	CDD:341343	10/20 (50%)
		TM helix 3	212..234	CDD:341343	9/22 (41%)
		TM helix 4	253..269	CDD:341343	5/15 (33%)
		TM helix 5	286..309	CDD:341343	7/22 (32%)
		TM helix 6	334..356	CDD:341343	13/21 (62%)
		TM helix 7	362..387	CDD:341343	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	178	1.000	Domainoid score	I3536
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21179
Inparanoid	1	1.050	289	1.000	Inparanoid score	I2792
Isobase	1	0.950	-	0	Normalized mean entropy	S5779
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001436
OrthoInspector	1	1.000	-	-		mtm8762
orthoMCL	1	0.900	-	-		OOG6_105420
Panther	1	1.100	-	-	O	PTHR45620
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2715
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.800