Protein Alignment Dh31-R and GLP1R

DIOPT Version :9

• Sequence 1: NP_001260951.1
• Gene: Dh31-R / 36475
• FlyBaseID: FBgn0052843
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: NP_002053.3
• Gene: GLP1R / 2740
• HGNCID: 4324
• Length: 463
• Species: Homo sapiens
• Alignment Length: 408
• Identity: 108/408 - (26%)
• Similarity: 179/408 - (43%)
• Gaps: 72/408 - (17%)

  Fly    41 RAACETRLNASGQLAGSGGPGAEAGTHCAGTFDGWLCWPDTAVGTSAYELCPDFI--TGFDPARY 103
            |..|:..|...        |.......|..|||.:.||||...|:.....||.::  ....|..:
Human    43 RRQCQRSLTED--------PPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGH 99

  Fly   104 AHKECGLDGEWFKHPLTNKTWSNYTTCVNL---------EDLNWRHTVNLISEVGYGTSLLAILL 159
            .::.|..:|.|.:...::..|.:.:.|...         |.|.:.:   :|..|||..|..|:::
Human   100 VYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLY---IIYTVGYALSFSALVI 161

  Fly   160 SLAILGYFKSLKCARITLHMNLFASF--------------------AANNSLWLVWYLLVMPNSE 204
            :.|||..|:.|.|.|..:|:||||||                    ||....|         :..
Human   162 ASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQW---------DGL 217

  Fly   205 LLHQSPMRCVALHITLHYFLLSNYSWMLCEGFYLHTVLVAAFISEKRLVKWLIAFGWGSPAIVIF 269
            |.:|..:.|..:.:.:.|.:.:||.|:|.||.||:|:|..:.:||:.:.:..::.|||.|.:.:.
Human   218 LSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVV 282

  Fly   270 VYSMARGLGGTPEDNRHCWMNQT--NYQNILMVPVCISMFLNLLFLCNIVRVVL--LKLNAPASI 330
            .:.:.:.|    .::..||...:  ||..|:.:|:..::.:|.|....::.:|:  ||.|.....
Human   283 PWGIVKYL----YEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKT 343

  Fly   331 QGSCGPSRTVLQAFRATLLLVPLLGLQYILTPFRPAPKHPWENTYEIISAFT----ASFQGLCVA 391
            ...|       :..::||.|:||||...::..| ...:|. ..|...|..||    .|||||.||
Human   344 DIKC-------RLAKSTLTLIPLLGTHEVIFAF-VMDEHA-RGTLRFIKLFTELSFTSFQGLMVA 399

  Fly   392 ILFCFCNGEVIAQMKRKW 409
            ||:||.|.||..:.::.|
Human   400 ILYCFVNNEVQLEFRKSW 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dh31-R	NP_001260951.1	HRM	65..132	CDD:280888	17/68 (25%)
		7tm_4	140..390	CDD:304433	75/277 (27%)
GLP1R	NP_002053.3	HRM	60..128	CDD:280888	17/67 (25%)
		7tm_2	144..398	CDD:278432	75/278 (27%)
		Important for allosteric inhibitor binding. /evidence=ECO:0000269|PubMed:28514449	352..355		1/2 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810