DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dh31-R and GCGR

DIOPT Version :9

Sequence 1:NP_001260951.1 Gene:Dh31-R / 36475 FlyBaseID:FBgn0052843 Length:604 Species:Drosophila melanogaster
Sequence 2:NP_000151.1 Gene:GCGR / 2642 HGNCID:4192 Length:477 Species:Homo sapiens


Alignment Length:463 Identity:128/463 - (27%)
Similarity:196/463 - (42%) Gaps:102/463 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 CAGTFDGWLCWPDTAVGTSAYELCPDFITGFDPA--RYAHKECGLDGEWFKHPLTNKTWSNYTTC 130
            |..|||.:.|||||...|:|...||.::......  |:..|.||.||:|.:.| ..:.|.:.:.|
Human    58 CNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGP-RGQPWRDASQC 121

  Fly   131 --------VNLEDLNWRHTVNLISEVGYGTSLLAILLSLAILGYFKSLKCARITLHMNLFASFAA 187
                    |..|......:..::..|||..||.|:||:|||||....|.|.|..:|.||||||..
Human   122 Q
MDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVL 186

  Fly   188 NNSLWLV---------------------WYLLVMPNSELLHQSPMRCVALHITLHYFLLSNYSWM 231
            ..|..||                     |         |...:...|....:.:.|.:::||.|:
Human   187 KASSVLVIDGLLRTRYSQKIGDDLSVSTW---------LSDGAVAGCRVAAVFMQYGIVANYCWL 242

  Fly   232 LCEGFYLHTVLVAAFISEKRLVKWLIAFGWGSPAIVIFVYSMARGLGGTPEDNRHCWMNQTN--Y 294
            |.||.|||.:|..|.:.|:......:..|||:|.:.:..:::.:.|    .:|..||.:..|  :
Human   243 LVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCL----FENVQCWTSNDNMGF 303

  Fly   295 QNILMVPVCISMFLNLLFLCNIVRVVLLKLNAPASIQGSCGPSRTV------LQAFRATLLLVPL 353
            ..||..||.:::.:|......||::::.||.|           |.:      .:..::||.|:||
Human   304 WWILRFPVFLAILINFFIFVRIVQLLVAKLRA-----------RQMHHTDYKFRLAKSTLTLIPL 357

  Fly   354 LGLQYILTPFRPAPKHPWENTYE----IISAFTASFQGLCVAILFCFCNGEVIAQMKRKWRMMCF 414
            ||:..::..| ...:|. :.|..    ....|.:|||||.||:|:||.|.||.::::|:|...  
Human   358 LGVHEVVFAF-VTDEHA-QGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRW-- 418

  Fly   415 SNRPRTNSYTATQVSFVRCGPPLPGEEKVXLKDMSAKRRASAGPQHHQPHHQSHQLSTDQQRARS 479
                             |.|..|..|..      ::..|||:.|.|..|       |.:.|..|.
Human   419 -----------------RLGKVLWEERN------TSNHRASSSPGHGPP-------SKELQFGRG 453

  Fly   480 QSLASSSS 487
            .....||:
Human   454 GGSQDSSA 461

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dh31-RNP_001260951.1 HRM 65..132 CDD:280888 23/73 (32%)
7tm_4 140..390 CDD:304433 78/282 (28%)
GCGRNP_000151.1 HRM 55..122 CDD:308439 22/64 (34%)
7tmB1_GCGR 136..410 CDD:320395 86/299 (29%)
TM helix 1 140..165 CDD:320395 12/24 (50%)
TM helix 2 174..196 CDD:320395 10/21 (48%)
TM helix 3 225..252 CDD:320395 10/26 (38%)
TM helix 4 264..284 CDD:320395 4/19 (21%)
TM helix 5 300..329 CDD:320395 8/28 (29%)
TM helix 6 345..370 CDD:320395 8/25 (32%)
Allosteric inhibitor binding. /evidence=ECO:0000269|PubMed:27111510, ECO:0000269|PubMed:28514451 350..353 1/2 (50%)
TM helix 7 379..404 CDD:320395 11/24 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 431..477 11/38 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4564
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X66
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.