DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh31-R and Glp1r

DIOPT Version :9

Sequence 1:	NP_001260951.1	Gene:	Dh31-R / 36475	FlyBaseID:	FBgn0052843	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_036860.2	Gene:	Glp1r / 25051	RGDID:	2703	Length:	463	Species:	Rattus norvegicus

Alignment Length:	435	Identity:	113/435 - (25%)
Similarity:	188/435 - (43%)	Gaps:	72/435 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GSGSGSGTNVASIAESVAESGPDFDALRAACETRLNASGQLAGSGGPGAEAGTHCAGTFDGWLCW 78
            |:...:|........|::|:...:...|..|:..|..:..||        .|..|..|||.:.||
  Rat    16 GAVGRAGPRPQGATVSLSETVQKWREYRHQCQRFLTEAPLLA--------TGLFCNRTFDDYACW 72

  Fly    79 PDTAVGTSAYELCPDFITGFDPARYAH--KECGLDGEWFKHPLTNKTWSNYTTCVNL-------- 133
            ||...|:.....||.::.........|  :.|..:|.|.....::..|.:.:.|...
  Rat    73 PDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGIWLHKDNSSLPWRDLSECEESKQGERNSP 137

  Fly   134 -EDLNWRHTVNLISEVGYGTSLLAILLSLAILGYFKSLKCARITLHMNLFASF------------ 185
             |.|   .::.:|..|||..|..|::::.|||..|:.|.|.|..:|:||||||
  Rat   138 EEQL---LSLYIIYTVGYALSFSALVIASAILVSFRHLHCTRNYIHLNLFASFILRALSVFIKDA 199

  Fly   186 --------AANNSLWLVWYLLVMPNSELLHQSPMRCVALHITLHYFLLSNYSWMLCEGFYLHTVL 242
                    ||....|         :..|.:|..:.|..:.:.:.|.:.:||.|:|.||.||:|:|
  Rat   200 ALKWMYSTAAQQHQW---------DGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLL 255

  Fly   243 VAAFISEKRLVKWLIAFGWGSPAIVIFVYSMARGLGGTPEDNRHCWMNQT--NYQNILMVPVCIS 305
            ..:..||:|:.|..::.|||.|.:.:..:.:.:.|    .::..||...:  ||..|:.:|:..:
  Rat   256 AFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYL----YEDEGCWTRNSNMNYWLIIRLPILFA 316

  Fly   306 MFLNLLFLCNIVRVVL--LKLNAPASIQGSCGPSRTVLQAFRATLLLVPLLGLQYILTPFRPAPK 368
            :.:|.|....::.:|:  ||.|........|       :..::||.|:||||...::..| ...:
  Rat   317 IGVNFLIFIRVICIVIAKLKANLMCKTDIKC-------RLAKSTLTLIPLLGTHEVIFAF-VMDE 373

  Fly   369 HPWENTYEIISAFT----ASFQGLCVAILFCFCNGEVIAQMKRKW 409
            |. ..|...:..||    .||||..||:|:||.|.||..:.::.|
  Rat   374 HA-RGTLRFVKLFTELSFTSFQGFMVAVLYCFVNNEVQMEFRKSW 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh31-R	NP_001260951.1	HRM	65..132	CDD:280888	18/68 (26%)
Dh31-R	NP_001260951.1	7tm_4	140..390	CDD:304433	75/277 (27%)
Glp1r	NP_036860.2	HRM	59..128	CDD:397086	18/68 (26%)
		7tmB1_GLP1R	141..419	CDD:341342	85/302 (28%)
		TM helix 1	144..168	CDD:341342	9/23 (39%)
		TM helix 2	177..198	CDD:341342	7/20 (35%)
		TM helix 3	227..249	CDD:341342	6/21 (29%)
		TM helix 4	268..284	CDD:341342	4/15 (27%)
		TM helix 5	302..325	CDD:341342	6/22 (27%)
		TM helix 6	350..372	CDD:341342	8/22 (36%)
		Important for allosteric inhibitor binding. /evidence=ECO:0000250\|UniProtKB:P43220	352..355		1/2 (50%)
		TM helix 7	381..406	CDD:341342	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810