DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh31-R and Vipr1

DIOPT Version :9

Sequence 1:	NP_001260951.1	Gene:	Dh31-R / 36475	FlyBaseID:	FBgn0052843	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_036817.1	Gene:	Vipr1 / 24875	RGDID:	3961	Length:	459	Species:	Rattus norvegicus

Alignment Length:	430	Identity:	126/430 - (29%)
Similarity:	208/430 - (48%)	Gaps:	79/430 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 THCAGTFDGWLCWPDTAVGTSAYELCPDFITGFDPARYAHKECGLDGEWFKHPLTNKTWSN---- 126
            |.|:..:|...|||.|..|.:....||.....|.|         :.|.......|.:.||.
  Rat    61 TGCSKMWDNLTCWPTTPRGQAVVLDCPLIFQLFAP---------IHGYNISRSCTEEGWSQLEPG 116

  Fly   127 -YTTCVNLED----------LNWRHTVNLISEVGYGTSLLAILLSLAILGYFKSLKCARITLHMN 180
             |.....|.|          ..:.:||.....:||..||.::|:::|||..|:.|.|.|..:||:
  Rat   117 PYHIACGLNDRASSLDEQQQTKFYNTVKTGYTIGYSLSLASLLVAMAILSLFRKLHCTRNYIHMH 181

  Fly   181 LFASFAANNSLWLVWYLLVMPNSELLH--QSPMRCVALHITLHYFLLSNYSWMLCEGFYLHTVLV 243
            ||.||....:...:..:.:..:.|:.|  ::.:.|.|..:...|.:::|:.|:|.||.||:|:|.
  Rat   182 LFMSFILRATAVFIKDMALFNSGEIDHCSEASVGCKAAVVFFQYCVMANFFWLLVEGLYLYTLLA 246

  Fly   244 AAFISEKRLVKWLIAFGWGSPAIVIFVYSMAR----GLGGTPEDNRHCW---MNQTNYQNILMVP 301
            .:|.||::.....|..|||.|::.|.::::.|    ..|        ||   :|.:.:. |:..|
  Rat   247 VSFFSERKYFWGYILIGWGVPSVFITIWTVVRIYFEDFG--------CWDTIINSSLWW-IIKAP 302

  Fly   302 VCISMFLN-LLFLCNIVRVVLLKLNAPASIQGSCGP-SRTVLQAFRATLLLVPLLGLQYILTPFR 364
            :.:|:.:| :||:| |:|:::.||..|...:....| ||..    ::||||:||.|:.|::..|.
  Rat   303 ILLSILVNFVLFIC-IIRILVQKLRPPDIGKNDSSPYSRLA----KSTLLLIPLFGIHYVMFAFF 362

  Fly   365 PAP-KHPWENTYEIISAFTASFQGLCVAILFCFCNGEVIAQMKRKWR------MMCFSNRPR--- 419
            |.. |...:..:|::   ..||||..||||:||.||||.|:::||||      ::.:|::.:
  Rat   363 PDNFKAQVKMVFELV---VGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWSSKSQHPW 424

  Fly   420 --TNSYT-ATQVSFV-RCGPPLPGEEKVXLKDMSAKRRAS 455
              :|..| :||||.: |..|             ||:|.:|
  Rat   425 GGSNGATCSTQVSMLTRVSP-------------SARRSSS 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh31-R	NP_001260951.1	HRM	65..132	CDD:280888	17/70 (24%)
Dh31-R	NP_001260951.1	7tm_4	140..390	CDD:304433	79/261 (30%)
Vipr1	NP_036817.1	HormR	59..130	CDD:214468	19/77 (25%)
		7tmB1_VIP-R1	140..407	CDD:320397	93/283 (33%)
		TM helix 1	143..167	CDD:320397	9/23 (39%)
		TM helix 2	176..197	CDD:320397	6/20 (30%)
		TM helix 3	217..239	CDD:320397	6/21 (29%)
		TM helix 4	258..274	CDD:320397	6/15 (40%)
		TM helix 5	292..315	CDD:320397	6/23 (26%)
		TM helix 6	342..364	CDD:320397	9/25 (36%)
		TM helix 7	369..394	CDD:320397	11/27 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910