DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh31-R and pdfr-1

DIOPT Version :9

Sequence 1:	NP_001260951.1	Gene:	Dh31-R / 36475	FlyBaseID:	FBgn0052843	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001021170.1	Gene:	pdfr-1 / 175942	WormBaseID:	WBGene00015735	Length:	546	Species:	Caenorhabditis elegans

Alignment Length:	511	Identity:	134/511 - (26%)
Similarity:	217/511 - (42%)	Gaps:	105/511 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SGTNVASIAESVAESGPDFDALRAA---CETRLNASGQLAGSGGPGAEAGTHCAGTFDGWLCWPD 80
            ||.||.: :.||.......|.|..:   |:..|: ...|.....|. :....|..|:|..||||.
Worm    25 SGWNVLA-STSVQAFNEAMDVLEESYPLCKKMLD-HNNLFPERDPN-DTRIWCNATYDTVLCWPP 86

  Fly    81 TAVGTSAYELCPDFITGFDPARYAHKECGLDGEWFKHPL-----TNKTWSNYTTCVN------LE 134
            |...:|....|| .:.|.||.:...|:|.:.|.|.....     |...|:|:|.|..      ::
Worm    87 TPANSSVTLQCP-HMKGLDPNKNITKDCHVSGVWSGRNAGEMGPTLPGWTNFTMCYTDEVIYIMQ 150

  Fly   135 DLNWRHTVNLISE----------VGYGTSLLAILLSLAILGYFKSLKCARITLHMNLFASFAANN 189
            :|| ..::.:..|          ||.|.||::::|:::|..||:.|:..|..||::|..:.....
Worm   151 NLN-NESLTIAQEVARNARKLEFVGLGLSLVSLILAISIFSYFRRLRVFRNLLHLHLMIAMLMVV 214

  Fly   190 SLWLVWYLLVMPNSE-----------LLHQSPMRCVALHITLHYFLLSNYSWMLCEGFYLHTVLV 243
            .|.||.|:.::...|           .::..|:.|..:...|.||....:.||..||.||:..:|
Worm   215 ILRLVLYIDLIFTGENGPHTNSAEGKTINTMPIVCEGMFFFLEYFKTVTFCWMFLEGIYLNNQIV 279

  Fly   244 AAFI-SEKRLVKWLIAFGWGSPAI-------VIFV---YSMARGLGG---TPEDNRHCWMNQTNY 294
            ..|. ||.:|:.:.|| |:|.|.:       |:.:   :.:.|.||.   .||    .|
Worm   280 FGFFNSEPKLLPYFIA-GYGIPLVHTMLWLLVVLIKKDFKVERCLGSYYLEPE----FW------ 333

  Fly   295 QNILMVPVCISMFLNLLFLCNIVRVVLLKLNAPASIQGSCGPSRTVLQAFRATLLLVPLLGLQYI 359
              ||..|....:.:||.|:||::||:..|:. .::.....|..::|    :|.::|:||||:..|
Worm   334 --ILDGPRMAELVINLFFICNVIRVLYSKVR-ESNNTSEAGLKKSV----KAAMMLLPLLGVPNI 391

  Fly   360 L--TPFRPAPKH-----PWENTYEIISAFTASFQGLCVAILFCFCNGEVIAQMK---RKWRMMCF 414
            :  .||.|...:     .|..|    ::||..:|||.||.::||.|.||...:|   .::|::..
Worm   392 MQTIPFAPTRDNIMVFAVWTYT----ASFTYMYQGLMVASIYCFTNKEVNHVLKTFYARYRLLHK 452

  Fly   415 S-------NRPRTNSYTATQVSFVRCGP------------PLPGEEKVXLKDMSAK 451
            |       :|...:.|.|...:.....|            |.|...|....|.:.|
Worm   453 SQNELRRGSRSVASHYAAKNGTANASAPQTNNADEFGKLSPFPSRSKKGSDDSTTK 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh31-R	NP_001260951.1	HRM	65..132	CDD:280888	23/71 (32%)
Dh31-R	NP_001260951.1	7tm_4	140..390	CDD:304433	78/291 (27%)
pdfr-1	NP_001021170.1	HRM	74..143	CDD:280888	23/69 (33%)
pdfr-1	NP_001021170.1	7tm_2	164..425	CDD:278432	77/282 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001436
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2715
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940