DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dh31-R and Glp1r

DIOPT Version :10

Sequence 1:NP_001260951.1 Gene:Dh31-R / 36475 FlyBaseID:FBgn0052843 Length:604 Species:Drosophila melanogaster
Sequence 2:NP_067307.2 Gene:Glp1r / 14652 MGIID:99571 Length:463 Species:Mus musculus


Alignment Length:431 Identity:118/431 - (27%)
Similarity:195/431 - (45%) Gaps:74/431 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 GTNVASIAESVAESGPDFDALRAACETRLNASGQLAGSGGPGAEAGTHCAGTFDGWLCWPDTAVG 84
            ||.| |::|:|.:    :...|..|:..|..:..||        .|..|..|||.:.||||...|
Mouse    27 GTTV-SLSETVQK----WREYRRQCQRFLTEAPLLA--------TGLFCNRTFDDYACWPDGPPG 78

  Fly    85 TSAYELCPDFITGFDPARYAH--KECGLDGEWFKHPLTNKTWSNYTTCVNLE--DLNWRH----T 141
            :.....||.::.........|  :.|..:|.|.....::..|.:.:.|...:  :.|:..    :
Mouse    79 SFVNVSCPWYLPWASSVLQGHVYRFCTAEGLWLHKDNSSLPWRDLSECEESKRGERNFPEEQLLS 143

  Fly   142 VNLISEVGYGTSLLAILLSLAILGYFKSLKCARITLHMNLFASF--------------------A 186
            :.:|..|||..|..|::::.|||..|:.|.|.|..:|:||||||                    |
Mouse   144 LYIIYTVGYALSFSALVIASAILVGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTA 208

  Fly   187 ANNSLWLVWYLLVMPNSELLHQSPMRCVALHITLHYFLLSNYSWMLCEGFYLHTVLVAAFISEKR 251
            |....|         :..|.:|..:.|..:.:.:.|.:.:||.|:|.||.||:|:|..:..||:|
Mouse   209 AQQHQW---------DGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVFSEQR 264

  Fly   252 LVKWLIAFGWGSPAIVIFVYSMARGLGGTPEDNRHCWMNQT--NYQNILMVPVCISMFLNLLFLC 314
            :.|..::.|||.|.:.:..:.:.:.|    .::..||...:  ||..|:.:|:..::.:|.|...
Mouse   265 IFKLYLSIGWGVPLLFVIPWGIVKYL----YEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFI 325

  Fly   315 NIVRVVL--LKLNAPASIQGSCGPSRTVLQAFRATLLLVPLLGLQYILTPFRPAPKHPWENTYEI 377
            .::.:|:  ||.|........|       :..::||.|:||||...::..| ...:|. ..|...
Mouse   326 RVICIVVSKLKANLMCKTDIKC-------RLAKSTLTLIPLLGTHEVIFAF-VMDEHA-RGTLRF 381

  Fly   378 ISAFT----ASFQGLCVAILFCFCNGEVIAQMKR---KWRM 411
            |..||    .|||||.||||:||.|.||..:.::   :||:
Mouse   382 IKLFTELSFTSFQGLMVAILYCFVNNEVQMEFRKCWERWRL 422

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dh31-RNP_001260951.1 HRM 65..132 CDD:397086 18/68 (26%)
7tmB1_NPR_B4_insect-like 139..411 CDD:320388 87/306 (28%)
TM helix 1 141..166 CDD:320388 9/24 (38%)
TM helix 2 175..197 CDD:320388 10/41 (24%)
TM helix 3 214..241 CDD:320388 9/26 (35%)
TM helix 4 253..273 CDD:320388 5/19 (26%)
TM helix 5 291..320 CDD:320388 6/30 (20%)
TM helix 6 339..366 CDD:320388 8/26 (31%)
TM helix 7 373..398 CDD:320388 15/28 (54%)
Glp1rNP_067307.2 HRM 59..128 CDD:397086 18/68 (26%)
7tmB1_GLP1R 141..419 CDD:341342 86/299 (29%)
TM helix 1 143..168 CDD:341342 9/24 (38%)
TM helix 2 177..199 CDD:341342 7/21 (33%)
TM helix 3 227..254 CDD:341342 9/26 (35%)
TM helix 4 266..286 CDD:341342 5/19 (26%)
TM helix 5 302..331 CDD:341342 6/28 (21%)
TM helix 6 345..372 CDD:341342 9/34 (26%)
Important for allosteric inhibitor binding. /evidence=ECO:0000250|UniProtKB:P43220 352..355 1/2 (50%)
TM helix 7 381..406 CDD:341342 14/24 (58%)

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