Protein Alignment Dh31-R and Gcgr

DIOPT Version :10

• Sequence 1: NP_001260951.1
• Gene: Dh31-R / 36475
• FlyBaseID: FBgn0052843
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: XP_017169752.1
• Gene: Gcgr / 14527
• MGIID: 99572
• Length: 497
• Species: Mus musculus
• Alignment Length: 442
• Identity: 122/442 - (27%)
• Similarity: 194/442 - (43%)
• Gaps: 85/442 - (19%)

  Fly    79 PDTAVGTSAYELCPDFITGFDPARYAHKECGLDGEWFKHPLTNKTWSNYTTC-VNLEDLNWRHTV 142
            |.|.:||:.:             |...|.||.||:|.:.| ..:.|.|.:.| ::.|::..:..|
Mouse    97 PGTYLGTTKH-------------RLVFKRCGPDGQWVRGP-RGQPWRNASQCQLDDEEIEVQKGV 147

  Fly   143 -------NLISEVGYGTSLLAILLSLAILGYFKSLKCARITLHMNLFASFA--ANNSLWLVWYLL 198
                   .::..|||..||.|:||:|.||...:.|.|.|..:|.||||||.  |.:.|.:.|.|.
Mouse   148 AKMYSSQQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLK 212

  Fly   199 VMPNSEL---------LHQSPMR-CVALHITLHYFLLSNYSWMLCEGFYLHTVLVAAFISEKRLV 253
            ...:.::         |....|. |....:.:.|.:::||.|:|.||.||:::|..|..||:...
Mouse   213 TRYSQKIGDDLSVSVWLSDGAMAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSLATFSERSFF 277

  Fly   254 KWLIAFGWGSPAIVIFVYSMARGLGGTPEDNRHCWMNQTN--YQNILMVPVCISMFLNLLFLCNI 316
            ...:..|||:|.:.:..:.:.:.|    .:|..||.:..|  :..||.:||.:::.:|.....:|
Mouse   278 SLYLGIGWGAPLLFVIPWVVVKCL----FENVQCWTSNDNMGFWWILRIPVFLALLINFFIFVHI 338

  Fly   317 VRVVLLKLNAP----ASIQGSCGPSRTVLQAFRATLLLVPLLGLQYILTPFRPAPKH---PWENT 374
            :.:::.||.|.    |..:         .:..|:||.|:||||:..::..| ...:|   ...:|
Mouse   339 IHLLVAKLRAHQMHYADYK---------FRLARSTLTLIPLLGVHEVVFAF-VTDEHAQGTLRST 393

  Fly   375 YEIISAFTASFQGLCVAILFCFCNGEVIAQMKRKWRMMCFSNRPRTNSYTATQVSFVRCGPPLPG 439
            ......|.:|||||.||:|:||.|.||.|::.|:||..                   :.|..|..
Mouse   394 KLFFDLFLSSFQGLLVAVLYCFLNKEVQAELMRRWRQW-------------------QEGKALQE 439

  Fly   440 EEKVXLKDMSAKRRASAGPQHHQPHHQSHQLSTDQQR------ARSQSLASS 485
            |.   |........|.|||.|..|..:...:|.....      :...|||||
Mouse   440 ER---LASSHGSHMAPAGPCHGDPCEKLQLMSAGSSSGTGCVPSMETSLASS 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dh31-R	NP_001260951.1	HRM	65..132	CDD:397086	15/53 (28%)
		7tmB1_NPR_B4_insect-like	139..411	CDD:320388	89/299 (30%)
		TM helix 1	141..166	CDD:320388	12/31 (39%)
		TM helix 2	175..197	CDD:320388	10/23 (43%)
		TM helix 3	214..241	CDD:320388	9/26 (35%)
		TM helix 4	253..273	CDD:320388	4/19 (21%)
		TM helix 5	291..320	CDD:320388	7/30 (23%)
		TM helix 6	339..366	CDD:320388	9/26 (35%)
		TM helix 7	373..398	CDD:320388	12/24 (50%)
Gcgr	XP_017169752.1	7tmB1_GCGR	149..429	CDD:320395	87/293 (30%)
		TM helix 1	153..178	CDD:320395	11/24 (46%)
		TM helix 2	187..209	CDD:320395	9/21 (43%)
		TM helix 3	238..265	CDD:320395	9/26 (35%)
		TM helix 4	277..297	CDD:320395	4/19 (21%)
		TM helix 5	313..342	CDD:320395	7/28 (25%)
		TM helix 6	358..383	CDD:320395	9/25 (36%)
		TM helix 7	392..417	CDD:320395	12/24 (50%)