Protein Alignment Dh31-R and CRHR1

DIOPT Version :9

• Sequence 1: NP_001260951.1
• Gene: Dh31-R / 36475
• FlyBaseID: FBgn0052843
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: NP_001138618.1
• Gene: CRHR1 / 1394
• HGNCID: 2357
• Length: 444
• Species: Homo sapiens
• Alignment Length: 451
• Identity: 126/451 - (27%)
• Similarity: 199/451 - (44%)
• Gaps: 109/451 - (24%)

  Fly    44 CETRLNASGQLAGSGGPGAEAGTHCAGTFDGWLCWPDTAVGTSAYELCPDFITG--FDPARYAHK 106
            ||: |:.:..::|.   ...|.....||     |||.:..|......||.|..|  ::.....::
Human    30 CES-LSLASNISGL---QCNASVDLIGT-----CWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYR 85

  Fly   107 ECGLDGEWFKHPLTNKTWS---NYTTCVNLEDLNWR-------HTVNLISEVGYGTSLLAILLSL 161
            ||          |.|.:|:   ||:.|  .|.||..       |...:|:.:|:..||:|:|::.
Human    86 EC----------LANGSWAARVNYSEC--QEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAF 138

  Fly   162 AIL---------------GYF--------------KSLKCARITLHMNLFASFAANNSLWLVWYL 197
            .:.               |..              :|::|.|..:|.||.::|...|:.|.|..|
Human   139 VLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQL 203

  Fly   198 LVMPNSELLHQSPMR-CVALHITLHYFLLSNYSWMLCEGFYLHTVLVAAFISEKRLVKWL-IAFG 260
            .:.|.   :|||.:. |..:....:||.::|:.||..||.||||.:|..: |..||.||: |..|
Human   204 TMSPE---VHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTY-STDRLRKWMFICIG 264

  Fly   261 WGSPAIVIFVYSMARGLGGTPEDNRHCWMNQ-----TNYQNILMVPVCISMFLNLLFLCNIVRVV 320
            ||.|..:|    :|..:|....||..||..:     |:|  |...|:.:.:.:|.:||.||||::
Human   265 WGVPFPII----VAWAIGKLYYDNEKCWFGKRPGVYTDY--IYQGPMILVLLINFIFLFNIVRIL 323

  Fly   321 LLKLNAPASIQGSCGPSRTV--LQAFRATLLLVPLLGLQYILTPFRPAPKHPWENTYEIISAFTA 383
            :.||.|..:       |.|:  .:|.:|||:|:||||:.|:|....|.........:...::|..
Human   324 MTKLRASTT-------SETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLE 381

  Fly   384 SFQGLCVAILFCFCNGEVIAQMKRKW--------------RMMCFSNRPRTNSYTATQVSF 430
            ||||..|::.:||.|.||.:.::::|              |.|.....|       |:|||
Human   382 SFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSP-------TRVSF 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dh31-R	NP_001260951.1	HRM	65..132	CDD:280888	18/71 (25%)
		7tm_4	140..390	CDD:304433	86/287 (30%)
CRHR1	NP_001138618.1	HormR	40..111	CDD:214468	23/90 (26%)
		Important for peptide agonist binding	99..108		4/10 (40%)
		7tm_2	116..388	CDD:278432	86/288 (30%)
		Important for antagonist binding	309..319		3/9 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2715
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840