DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh31-R and Calcr

DIOPT Version :9

Sequence 1:	NP_001260951.1	Gene:	Dh31-R / 36475	FlyBaseID:	FBgn0052843	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_001363947.1	Gene:	Calcr / 12311	MGIID:	101950	Length:	533	Species:	Mus musculus

Alignment Length:	517	Identity:	160/517 - (30%)
Similarity:	251/517 - (48%)	Gaps:	97/517 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SGTNVASIAESVAESGPD-------------FDALRAACETRLNASGQLAGSGGPGAEAGTHCAG 70
            |.|.|.....::.:||.|             .|| :..|..|::   ||....|    .|.:|..
Mouse    35 SPTPVLQAPTNLTDSGLDQEPFLYLVGRKKLLDA-QYKCYDRIH---QLPSYEG----EGLYCNR 91

  Fly    71 TFDGWLCWPDTAVGTSAYELCPDFITGFDPARYAHKECGLDGEWFKHPLTNKTWSNYTTC--VNL 133
            |:|||:||.||..|.:||:.|||:...||.|....|.|..:||||:||.:|:||||||.|  ...
Mouse    92 TWDGWMCWDDTPAGATAYQHCPDYFPDFDTAEKVSKYCDENGEWFRHPDSNRTWSNYTLCNAFTS 156

  Fly   134 EDLNWRHTVNLISEVGYGTSLLAILLSLAILGYFKSLKCARITLHMNLFASFAANNSLWLVWYLL 198
            |.|...:.:..::.||:..|:.|::.|:.|...||:|.|.|:|||.::|.::..|:.:.::..:.
Mouse   157 EKLQNAYVLYYLALVGHSLSIAALVASMLIFWIFKNLSCQRVTLHKHMFLTYILNSIIIIIHLVE 221

  Fly   199 VMPNSELLHQSPMR-------------------------------------CVALHITLHYFLLS 226
            |:||.:|:.:.||.                                     |..||....|.:..
Mouse   222 VVPNGDLVRRDPMHIFHHNTHMWTMQWELSPPLPLSAHEGKMDPHASEVISCKVLHFLHQYMMSC 286

  Fly   227 NYSWMLCEGFYLHTVLVAAFISEKRLVKWLIAFGWGSPAIVIFVYSMARGLGGTPEDNRHCWMN- 290
            ||.||||||.||||::|.|..::::.::|....|||.|.:...::::.|.|    ..|.:||::
Mouse   287 NYFWMLCEGIYLHTLIVMAVFTDEQRLRWYYLLGWGFPIVPTIIHAITRAL----YYNDNCWLSA 347

  Fly   291 QTNYQNILMVPVCISMFLNLLFLCNIVRVVLLKLNAPASIQGSCGPSRTVLQAFRATLLLVPLLG 355
            :|:...|:..||.:::.:|..||.|||||::.|:.     |.....|...|:|.:||::||||||
Mouse   348 ETHLLYIIHGPVMVALVVNFFFLLNIVRVLVTKMR-----QTHEAESYMYLKAVKATMVLVPLLG 407

  Fly   356 LQYILTPFRPAPKHPWENTYEIISAFTASFQGLCVAILFCFCNGEVIAQMKRKWRMMCFS----- 415
            :|:::.|:||:.| .....|:.:......|||..||.::||||.||...:||:|......
Mouse   408 IQFVVFPWRPSNK-VLGKIYDYLMHSLIHFQGFFVATIYCFCNHEVQVTLKRQWTQFKIQWSQRW 471

  Fly   416 ---NRPRTNSYTATQ-VSFVR--------C-----GPPL---PGEEKVXLKDMSA-KRRASA 456
               .||.....:|.: |:|..        |     .||:   .|||.. :..|:. ::.|||
Mouse   472 GRRRRPTNRVVSAPRAVAFAEPDGLPIYICHQEPRNPPISNNEGEESTEMIPMNVIQQDASA 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh31-R	NP_001260951.1	HRM	65..132	CDD:280888	35/68 (51%)
Dh31-R	NP_001260951.1	7tm_4	140..390	CDD:304433	84/287 (29%)
Calcr	NP_001363947.1	HRM	86..154	CDD:367186	35/67 (52%)
		7tmB1_calcitonin_R	162..472	CDD:341343	95/319 (30%)
		TM helix 1	164..189	CDD:341343	6/24 (25%)
		TM helix 2	198..220	CDD:341343	5/21 (24%)
		TM helix 3	274..301	CDD:341343	14/26 (54%)
		TM helix 4	313..333	CDD:341343	5/19 (26%)
		TM helix 5	348..377	CDD:341343	11/28 (39%)
		TM helix 6	391..418	CDD:341343	13/26 (50%)
		TM helix 7	424..449	CDD:341343	8/24 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	178	1.000	Domainoid score	I3536
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	289	1.000	Inparanoid score	I2792
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1005634at2759
OrthoFinder	1	1.000	-	-		FOG0001436
OrthoInspector	1	1.000	-	-		mtm8762
orthoMCL	1	0.900	-	-		OOG6_105420
Panther	1	1.100	-	-	O	PTHR45620
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2715
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860