Protein Alignment Dh31-R and Calcr

DIOPT Version :10

• Sequence 1: NP_001260951.1
• Gene: Dh31-R / 36475
• FlyBaseID: FBgn0052843
• Length: 604
• Species: Drosophila melanogaster
• Sequence 2: NP_031614.2
• Gene: Calcr / 12311
• MGIID: 101950
• Length: 533
• Species: Mus musculus
• Alignment Length: 517
• Identity: 160/517 - (30%)
• Similarity: 251/517 - (48%)
• Gaps: 97/517 - (18%)

  Fly    19 SGTNVASIAESVAESGPD-------------FDALRAACETRLNASGQLAGSGGPGAEAGTHCAG 70
            |.|.|.....::.:||.|             .|| :..|..|::   ||....|    .|.:|..
Mouse    35 SPTPVLQAPTNLTDSGLDQEPFLYLVGRKKLLDA-QYKCYDRIH---QLPSYEG----EGLYCNR 91

  Fly    71 TFDGWLCWPDTAVGTSAYELCPDFITGFDPARYAHKECGLDGEWFKHPLTNKTWSNYTTC--VNL 133
            |:|||:||.||..|.:||:.|||:...||.|....|.|..:||||:||.:|:||||||.|  ...
Mouse    92 TWDGWMCWDDTPAGATAYQHCPDYFPDFDTAEKVSKYCDENGEWFRHPDSNRTWSNYTLCNAFTS 156

  Fly   134 EDLNWRHTVNLISEVGYGTSLLAILLSLAILGYFKSLKCARITLHMNLFASFAANNSLWLVWYLL 198
            |.|...:.:..::.||:..|:.|::.|:.|...||:|.|.|:|||.::|.::..|:.:.::..:.
Mouse   157 EKLQNAYVLYYLALVGHSLSIAALVASMLIFWIFKNLSCQRVTLHKHMFLTYILNSIIIIIHLVE 221

  Fly   199 VMPNSELLHQSPMR-------------------------------------CVALHITLHYFLLS 226
            |:||.:|:.:.||.                                     |..||....|.:..
Mouse   222 VVPNGDLVRRDPMHIFHHNTHMWTMQWELSPPLPLSAHEGKMDPHASEVISCKVLHFLHQYMMSC 286

  Fly   227 NYSWMLCEGFYLHTVLVAAFISEKRLVKWLIAFGWGSPAIVIFVYSMARGLGGTPEDNRHCWMN- 290
            ||.||||||.||||::|.|..::::.::|....|||.|.:...::::.|.|    ..|.:||::
Mouse   287 NYFWMLCEGIYLHTLIVMAVFTDEQRLRWYYLLGWGFPIVPTIIHAITRAL----YYNDNCWLSA 347

  Fly   291 QTNYQNILMVPVCISMFLNLLFLCNIVRVVLLKLNAPASIQGSCGPSRTVLQAFRATLLLVPLLG 355
            :|:...|:..||.:::.:|..||.|||||::.|:.     |.....|...|:|.:||::||||||
Mouse   348 ETHLLYIIHGPVMVALVVNFFFLLNIVRVLVTKMR-----QTHEAESYMYLKAVKATMVLVPLLG 407

  Fly   356 LQYILTPFRPAPKHPWENTYEIISAFTASFQGLCVAILFCFCNGEVIAQMKRKWRMMCFS----- 415
            :|:::.|:||:.| .....|:.:......|||..||.::||||.||...:||:|......
Mouse   408 IQFVVFPWRPSNK-VLGKIYDYLMHSLIHFQGFFVATIYCFCNHEVQVTLKRQWTQFKIQWSQRW 471

  Fly   416 ---NRPRTNSYTATQ-VSFVR--------C-----GPPL---PGEEKVXLKDMSA-KRRASA 456
               .||.....:|.: |:|..        |     .||:   .|||...:..|:. ::.|||
Mouse   472 GRRRRPTNRVVSAPRAVAFAEPDGLPIYICHQEPRNPPISNNEGEESTEMIPMNVIQQDASA 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dh31-R	NP_001260951.1	HRM	65..132	CDD:397086	35/68 (51%)
		7tmB1_NPR_B4_insect-like	139..411	CDD:320388	95/309 (31%)
		TM helix 1	141..166	CDD:320388	6/24 (25%)
		TM helix 2	175..197	CDD:320388	5/21 (24%)
		TM helix 3	214..241	CDD:320388	14/26 (54%)
		TM helix 4	253..273	CDD:320388	5/19 (26%)
		TM helix 5	291..320	CDD:320388	11/28 (39%)
		TM helix 6	339..366	CDD:320388	13/26 (50%)
		TM helix 7	373..398	CDD:320388	8/24 (33%)
Calcr	NP_031614.2	HRM	86..154	CDD:397086	35/67 (52%)
		7tmB1_calcitonin_R	162..472	CDD:341343	95/319 (30%)
		TM helix 1	164..189	CDD:341343	6/24 (25%)
		TM helix 2	198..220	CDD:341343	5/21 (24%)
		TM helix 3	274..301	CDD:341343	14/26 (54%)
		TM helix 4	313..333	CDD:341343	5/19 (26%)
		TM helix 5	348..377	CDD:341343	11/28 (39%)
		TM helix 6	391..418	CDD:341343	13/26 (50%)
		TM helix 7	424..449	CDD:341343	8/24 (33%)