DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh31-R and Calcr

DIOPT Version :9

Sequence 1:	NP_001260951.1	Gene:	Dh31-R / 36475	FlyBaseID:	FBgn0052843	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_446268.2	Gene:	Calcr / 116506	RGDID:	621001	Length:	533	Species:	Rattus norvegicus

Alignment Length:	516	Identity:	156/516 - (30%)
Similarity:	248/516 - (48%)	Gaps:	96/516 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SGTNVASIAESVAESGPD-------------FDALRAACETRLNASGQLAGSGGPGAEAGTHCAG 70
            |.|.|.....::.:||.|             .|| :..|..|:.   ||.    |....|.:|..
  Rat    35 SPTPVLQAPTNLTDSGLDQEPFLYLVGRKKLLDA-QYKCYDRIQ---QLP----PYEGEGPYCNR 91

  Fly    71 TFDGWLCWPDTAVGTSAYELCPDFITGFDPARYAHKECGLDGEWFKHPLTNKTWSNYTTC--VNL 133
            |:|||:||.||..|..:|:.|||:...|||.....|.|..:||||:||.:|:||||||.|  ...
  Rat    92 TWDGWMCWDDTPAGVMSYQHCPDYFPDFDPTEKVSKYCDENGEWFRHPDSNRTWSNYTLCNAFTP 156

  Fly   134 EDLNWRHTVNLISEVGYGTSLLAILLSLAILGYFKSLKCARITLHMNLFASFAANNSLWLVWYLL 198
            :.|:..:.:..::.||:..|:.|::.|:.|..:||:|.|.|:|||.|:|.::..|:.:.::..:.
  Rat   157 DKLHNAYVLYYLALVGHSMSIAALIASMGIFLFFKNLSCQRVTLHKNMFLTYILNSIIIIIHLVE 221

  Fly   199 VMPNSELLHQSPMR-------------------------------------CVALHITLHYFLLS 226
            |:||.:|:.:.||.                                     |..||....|.:..
  Rat   222 VVPNGDLVRRDPMHIFHHNTYMWTMQWELSPPLPLSAHEGKMDPHDSEVISCKILHFFHQYMMAC 286

  Fly   227 NYSWMLCEGFYLHTVLVAAFISEKRLVKWLIAFGWGSPAIVIFVYSMARGLGGTPEDNRHCWMN- 290
            ||.||||||.||||::|.|..:|.:.::|....|||.|.:...::::.|.:    ..|.:||::
  Rat   287 NYFWMLCEGIYLHTLIVMAVFTEDQRLRWYYLLGWGFPIVPTIIHAITRAV----YYNDNCWLST 347

  Fly   291 QTNYQNILMVPVCISMFLNLLFLCNIVRVVLLKLNAPASIQGSCGPSRTVLQAFRATLLLVPLLG 355
            :|:...|:..||..::.:|..||.|||||::.|:.     |.....:...|:|.:||::||||||
  Rat   348 ETHLLYIIHGPVMAALVVNFFFLLNIVRVLVTKMR-----QTHEAEAYMYLKAVKATMVLVPLLG 407

  Fly   356 LQYILTPFRPAPKHPWENTYEIISAFTASFQGLCVAILFCFCNGEVIAQMKRKWRMMCFS----- 415
            :|:::.|:||:.| .....|:.:......|||..||.::||||.||...:||:|......
  Rat   408 IQFVVFPWRPSNK-VLGKIYDYLMHSLIHFQGFFVATIYCFCNHEVQVTLKRQWAQFKIQWSHRW 471

  Fly   416 ---NRPRTNSYTATQ-VSFVRCG-------------PPL---PGEEKVXLKDMSAKRRASA 456
               .||.....:|.: |:|...|             ||:   .|||...:..|:..::.|:
  Rat   472 GRRRRPTNRVVSAPRAVAFAEPGGLPIYICHQEPRNPPVSNNEGEEGTEMIPMNVIQQDSS 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh31-R	NP_001260951.1	HRM	65..132	CDD:280888	34/68 (50%)
Dh31-R	NP_001260951.1	7tm_4	140..390	CDD:304433	84/287 (29%)
Calcr	NP_446268.2	HRM	86..154	CDD:280888	34/67 (51%)
Calcr	NP_446268.2	7tm_2	162..441	CDD:278432	84/288 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	176	1.000	Domainoid score	I3514
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2751
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1005634at2759
OrthoFinder	1	1.000	-	-		FOG0001436
OrthoInspector	1	1.000	-	-		mtm9007
orthoMCL	1	0.900	-	-		OOG6_105420
Panther	1	1.100	-	-	O	PTHR45620
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830