DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dh31-R and vipr1

DIOPT Version :9

Sequence 1:	NP_001260951.1	Gene:	Dh31-R / 36475	FlyBaseID:	FBgn0052843	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_031759879.1	Gene:	vipr1 / 100497291	XenbaseID:	XB-GENE-5991267	Length:	444	Species:	Xenopus tropicalis

Alignment Length:	419	Identity:	122/419 - (29%)
Similarity:	194/419 - (46%)	Gaps:	78/419 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 AEAGTH---CAGTFDGWLCWPDTAVGTSAYELCPDFI-------------------TGFDPARYA 104
            :||..|   |..::|...||...:||......|||:.                   |...||.||
Frog    44 SEAENHTLGCKASWDNITCWRSASVGEVVVMPCPDYFGFFSNVQGNVSRNCTEHGWTDMFPAPYA 108

  Fly   105 HKECGLDGEWFKHPLTNKTWSNYTTCVNLEDLNWRHTVNLISEVGYGTSLLAILLSLAILGYFKS 169
             ..||.|        ||.|.:..|...::....:        .:|:..||:::..::.||.:|:.
Frog   109 -IACGFD--------TNNTTNGQTEFFSMIKTGY--------TIGHSVSLISLTAAMIILFFFRK 156

  Fly   170 LKCARITLHMNLFASFAANNSLWLVWYLLVMPNSELLH--QSPMRCVALHITLHYFLLSNYSWML 232
            |.|.|..:||:||.||........|..:::..:.|..|  ...:.|.|..:...|.:::|:.|:|
Frog   157 LHCTRNYIHMHLFMSFIMRAIAVFVKDIVLFESGEFDHCFVGSVGCKAAMVFFQYCIMANFFWLL 221

  Fly   233 CEGFYLHTVLVAAFISEKRLVKWLIAFGWGSPAIVIFVYSMARGLGGTPEDNRHCWMN-QTNYQN 296
            .||.||||:||.:|.|||:...|.|..|||||.:.|..:::.|    ...|:..||.. ::.:..
Frog   222 VEGLYLHTLLVISFFSEKKYFWWYILIGWGSPTVFITAWTVTR----IHFDDSGCWDTIESPFWW 282

  Fly   297 ILMVPVCISMFLNLLFLCNIVRVVLLKLNAPASIQGSCGPSRT--VLQAFRATLLLVPLLGLQYI 359
            |:..|:.||:.:|.:|...|:|:::.||::|     ..|.:..  ..:..::||||:||.|:.||
Frog   283 IIRAPILISISVNFIFFICIIRILVQKLHSP-----DVGRNENSQYTRLAKSTLLLIPLFGVHYI 342

  Fly   360 LTPFRPAPKHPWENTYE-----IISAFTASFQGLCVAILFCFCNGEVIAQMKRKWRMMCFS---- 415
            :..|.|       :.::     |:.....||||..||||:||.||||..::|||||.....
Frog   343 MFAFFP-------DNFKVEIKLIVELVLGSFQGFVVAILYCFLNGEVQGELKRKWRRWHLERFLG 400

  Fly   416 -----NRPRTNS---YTATQVSFV-RCGP 435
                 :.|...|   ..:||:|.: :|.|
Frog   401 SDMKYHHPSLGSNGTNFSTQISMLTKCSP 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh31-R	NP_001260951.1	HRM	65..132	CDD:280888	22/88 (25%)
Dh31-R	NP_001260951.1	7tm_4	140..390	CDD:304433	76/259 (29%)
vipr1	XP_031759879.1	HormR	50..120	CDD:214468	20/78 (26%)
		7tm_GPCRs	126..392	CDD:421689	90/289 (31%)
		TM helix 1	128..153	CDD:410628	5/32 (16%)
		TM helix 2	162..184	CDD:410628	7/21 (33%)
		TM helix 3	203..230	CDD:410628	10/26 (38%)
		TM helix 4	242..262	CDD:410628	8/19 (42%)
		TM helix 5	277..306	CDD:410628	8/28 (29%)
		TM helix 6	322..349	CDD:410628	11/33 (33%)
		TM helix 7	354..379	CDD:410628	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000