DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dh31-R and gcgr

DIOPT Version :9

Sequence 1:	NP_001260951.1	Gene:	Dh31-R / 36475	FlyBaseID:	FBgn0052843	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	XP_004916426.1	Gene:	gcgr / 100487356	XenbaseID:	XB-GENE-5918476	Length:	483	Species:	Xenopus tropicalis

Alignment Length:	497	Identity:	128/497 - (25%)
Similarity:	209/497 - (42%)	Gaps:	90/497 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ASIAESVAESGPDFDALRAACETRLNASGQLAGSGGPGAEAGTHCAGTFDGWLCWPDTAVGTSAY 88
            |.|.:...|:...::.     |.|.|.|.:      |.| ||..|..|||.:.||||....|:..
Frog    22 AQIMDEAYENWRKYET-----ECRHNMSQE------PPA-AGLVCNRTFDRYCCWPDALPNTTVS 74

  Fly    89 ELCPDFITGFDPARY--AHKECGLDGEWFKHPLTNKTWSNYTTCVN----LEDLNWR--HTVNLI 145
            ..||.|:......::  .:|.|..||:|.:.        :...|.|    :||..::  ....::
Frog    75 VPCPWFLPWHLKVQHGLVYKHCEPDGQWAER--------DAQECENDDKQIEDKYFKIYDNFKIM 131

  Fly   146 SEVGYGTSLLAILLSLAILGYFKSLKCARITLHMNLFASFA-----------------------A 187
            ..|||..||..::|:.|||..|..|.|.|..:|:||||||.                       .
Frog   132 YTVGYSVSLGTLILAFAILVGFSKLHCMRNYIHINLFASFILRAVSVLVLDTMLKTRYNENEKFE 196

  Fly   188 NNSLWLVWYLLVMPNSELLHQSPMRCVALHITLHYFLLSNYSWMLCEGFYLHTVLVAAFISEKRL 252
            :..|||        :||.|    :.|....:.:.|.:::||.|::.||.||:.:||.|..||:..
Frog   197 DTHLWL--------SSEAL----VGCRVAAVLMQYGIIANYYWLMVEGIYLYNLLVLAVFSERSY 249

  Fly   253 VKWLIAFGWGSPAIVIFVYSMARGLGGTPEDNRHCWMNQTN--YQNILMVPVCISMFLNLLFLCN 315
            ....:..|||:||:.|..:...|    ...:|..||....|  :..|:...|.:::.:|.:....
Frog   250 FALYLCIGWGAPALFIIPWVAVR----YTYENTLCWSTNNNMGFWWIIRSSVLLAIVINFVIFVR 310

  Fly   316 IVRVVLLKLNAPASIQGSCGPSRTVLQAFR---ATLLLVPLLGLQYILTPFRPAPKHPWENTYEI 377
            |:::::.|:.|        ...|.....||   :||.|:||||:..:...|  .|:.....|..:
Frog   311 IIQILVSKMRA--------HQMRYTDYKFRLAKSTLTLIPLLGIHEVAFAF--LPEETVHGTLRL 365

  Fly   378 I----SAFTASFQGLCVAILFCFCNGEVIAQMKRKWRMMCFSNRPRTNSYTATQVSFVRCGPPLP 438
            :    ..|.:||||:.||:|:||.|.||.:::.:||:.... .:.....|..|.....|.|....
Frog   366 VKLFFDLFISSFQGMLVAVLYCFVNKEVQSELLKKWKRWKL-GKDIKGEYKHTYTQTPRVGASTV 429

  Fly   439 GEEKVXLKDMSAKRRASAGPQHHQPHHQSHQLSTDQQRARSQ 480
            .|..   |.:....:.:..|:|:...:...:.||.:....|:
Frog   430 YENH---KLVGCWHKGTGKPRHNGSMYYDDKNSTTENITLSE 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dh31-R	NP_001260951.1	HRM	65..132	CDD:280888	19/68 (28%)
Dh31-R	NP_001260951.1	7tm_4	140..390	CDD:304433	75/281 (27%)
gcgr	XP_004916426.1	HRM	51..113	CDD:367186	19/69 (28%)
		7tmB1_GCGR	123..403	CDD:320395	85/305 (28%)
		TM helix 1	127..152	CDD:320395	9/24 (38%)
		TM helix 2	161..183	CDD:320395	7/21 (33%)
		TM helix 3	211..238	CDD:320395	8/26 (31%)
		TM helix 4	250..270	CDD:320395	6/19 (32%)
		TM helix 5	286..315	CDD:320395	5/28 (18%)
		TM helix 6	331..356	CDD:320395	10/26 (38%)
		TM helix 7	365..390	CDD:320395	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000