DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42319 and DLG5

DIOPT Version :9

Sequence 1:	NP_001137648.1	Gene:	CG42319 / 36473	FlyBaseID:	FBgn0259219	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_004738.3	Gene:	DLG5 / 9231	HGNCID:	2904	Length:	1919	Species:	Homo sapiens

Alignment Length:	481	Identity:	90/481 - (18%)
Similarity:	163/481 - (33%)	Gaps:	157/481 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 AFDVDSDAYATK-----------DDSRWGF-LITGGAEFHMP----LTVFQVTPNGLADKAGIRL 83
            |.|.||..:.|:           |....|| :..|..|...|    :.|.:|....:|| ..:|:
Human   608 AIDTDSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIAD-GRLRV 671

  Fly    84 GDIILEINEEDASQLTLSQAHEKINSTPKKIHFLLRNMEEDDPMGQFEAGEEKSIVMRVPKPLPP 148
            .|.:|.||:.|.......||.:.:.:....|:.::|              ..||:..:|..||
Human   672 NDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVR--------------RRKSLGGKVVTPL-- 720

  Fly   149 PSGRIRASSIEMRLLEMQRKLSAIAEIPKILCS---TLATVSQNFGRMSESEVDEDDVGEEEAYV 210
               .|..|..:...:.::..:.|.|.:|....:   :|| |......::...:|...:.|.|:.:
Human   721 ---HINLSGQKDSGISLENGVYAAAVLPGSPAAKEGSLA-VGDRIVAINGIALDNKSLNECESLL 781

  Fly   211 QRKFSYDEDALDFELR---------NGEQAGDTDSDEEDLV----------------LVREEDAE 250
            :.    .:|:|...|.         :|:...:...|.:.::                |::..::.
Human   782 RS----CQDSLTLSLLKVFPQSSSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNNST 842

  Fly   251 DVDV-------------PKGAKQSKLLK-------DVTPES-DYASEANYPA--NEASDDTE--- 289
            ..|:             |.|...|.|.|       .|.|:: ..|||.:..:  ::||.|..
Human   843 QTDIFYTDRLEDRKEPGPPGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDASGDRGFGL 907

  Fly   290 ---------SDDEDEPGSTVYFMKLPAAAAEDTYSSTEDEDDSDFLNTTYTWNLRNVPKLRINDA 345
                     ...|.|.|        |....|    ::.|:.||:..|:..||     ||..::..
Human   908 VDVRGRRPLLPFETEVG--------PCGVGE----ASLDKADSEGSNSGGTW-----PKAMLSST 955

  Fly   346 EAEGELTLGHQAREVPQQEQPQEKQPCLEPE-------PPKV-----------------RPATPT 386
            ....:|::         .::|::::...:|.       |||:                 |....|
Human   956 AVPEKLSV---------YKKPKQRKSIFDPNTFKRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLT 1011

  Fly   387 PKAPPQESAEGQTQKLLFRLDKLERS 412
            |..||:.|   .:.|...||:....|
Human  1012 PPKPPRRS---DSIKFQHRLETSSES 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42319	NP_001137648.1	PDZ_signaling	45..119	CDD:238492	20/89 (22%)
DLG5	NP_004738.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..142
		Takusan	130..212	CDD:282652
		TPR_MLP1_2	231..353	CDD:285204
		COG1340	295..587	CDD:224259
		FliJ	310..449	CDD:304890
		BAR	417..601	CDD:299863
		PDZ_signaling	620..707	CDD:238492	19/87 (22%)
		DegQ	<702..771	CDD:223343	15/88 (17%)
		PDZ_signaling	722..790	CDD:238492	13/72 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	927..1122		25/129 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1150..1187
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1201..1230
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1245..1264
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1271..1306
		PDZ	1347..1429	CDD:214570
		dbPDZ_assoc	1427..1499	CDD:293216
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1434..1493
		PDZ	1499..1582	CDD:214570
		SH3_DLG5	1597..1659	CDD:212794
		GuKc	1732..1908	CDD:214504
		Guanylate_kin	1740..1907	CDD:279019
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900