DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42319 and PDLIM1

DIOPT Version :9

Sequence 1:	NP_001137648.1	Gene:	CG42319 / 36473	FlyBaseID:	FBgn0259219	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_066272.1	Gene:	PDLIM1 / 9124	HGNCID:	2067	Length:	329	Species:	Homo sapiens

Alignment Length:	246	Identity:	52/246 - (21%)
Similarity:	97/246 - (39%)	Gaps:	39/246 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 WGFLITGGAEFHMPLTVFQVTPNGLADKAGIRLGDIILEINEEDASQLTLSQAHEKINSTPKKIH 115
            |||.:.||.:|..||.:.:|||...|..|.:.:||:|..|:.|:.|.:|..:|..:|......:.
Human    14 WGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSNMTHLEAQNRIKGCTDNLT 78

  Fly   116 FLLRNMEEDDPMGQFEAGEEKSIVMRVPKPLPPPSGRIRASSIEMRLLEMQRKLSAI--AEIPKI 178
            ..:...|.                 :|..||....|  :....:|.|....:::..|  |.....
Human    79 LTVARSEH-----------------KVWSPLVTEEG--KRHPYKMNLASEPQEVLHIGSAHNRSA 124

  Fly   179 LCSTLATVSQNFGRMSESEVDEDDVGEEEAYVQRKFSYDEDALDFE-LRNGEQAGDTDSD----- 237
            :..|.:..|....|:..::.: :..|   .|.....|...:||:.: ..:|.:|.....|
Human   125 MPFTASPASSTTARVITNQYN-NPAG---LYSSENISNFNNALESKTAASGVEANSRPLDHAQPP 185

  Fly   238 -------EEDLVLVREEDAEDVDVPKGAKQSKLLKDVTPESDYASEANYPA 281
                   |.::..:.:|..|..:.||.:....:|:::. ||:...:.|.|:
Human   186 SSLVIDKESEVYKMLQEKQELNEPPKQSTSFLVLQEIL-ESEEKGDPNKPS 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42319	NP_001137648.1	PDZ_signaling	45..119	CDD:238492	22/67 (33%)
PDLIM1	NP_066272.1	PDZ_signaling	10..82	CDD:238492	22/67 (33%)
		DUF4749	138..230	CDD:318205	17/96 (18%)
		LIM_CLP36	260..311	CDD:188832
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003437
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.100