DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42319 and PDZD3

DIOPT Version :9

Sequence 1:	NP_001137648.1	Gene:	CG42319 / 36473	FlyBaseID:	FBgn0259219	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	XP_011541302.1	Gene:	PDZD3 / 79849	HGNCID:	19891	Length:	571	Species:	Homo sapiens

Alignment Length:	382	Identity:	86/382 - (22%)
Similarity:	141/382 - (36%)	Gaps:	113/382 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 YATKDDSRWGFLITGGAE--FHMPLTVFQVTPNGLADKAGIRLGDIILEINEEDASQLTLSQAHE 105
            :..||:..:||.:|.|.:  |.:.|:.     .|.|::||:..|..:||:|.....:.|.:|...
Human   225 HIVKDEGGFGFSVTHGNQGPFWLVLST-----GGAAERAGVPPGARLLEVNGVSVEKFTHNQLTR 284

  Fly   106 KINSTPKKIHFLLRNMEEDDPMGQFEAGEEKSIVMRVPKPLPPPSGRIRASSIEMRLLEMQRKLS 170
            |:                      :::|::.::::..|:             :|.:..::...|:
Human   285 KL----------------------WQSGQQVTLLVAGPE-------------VEEQCRQLGLPLA 314

  Fly   171 A-IAE---IP-KILCSTLATVSQNFGRMSESEVDEDDVGEEEAYVQR--KFSYDEDALDFELRNG 228
            | :||   :| |..|..|....|.||.:         :.||:....|  :|.::.|......:.|
Human   315 APLAEGWALPTKPRCLHLEKGPQGFGFL---------LREEKGLDGRPGQFLWEVDPGLPAKKAG 370

  Fly   229 EQAGDTDSDEEDLVLVREEDA------EDVDVPKGAKQSKLLKDVTPESD-YASEANYPANEASD 286
            .||||.      ||.|..|..      |.|...:|......|..|.||:| :.|..........:
Human   371 MQAGDR------LVAVAGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLE 429

  Fly   287 DTESDDEDEPGSTVYFMKLPAAAAEDTYSSTED---EDDS----------DFL----NTTYTWNL 334
            :||:     |.|       |..::..:...|||   ||.|          .||    ..:|.:.|
Human   430 NTEA-----PAS-------PRGSSSASLVETEDPSLEDTSVPSVPLGSRQCFLYPGPGGSYGFRL 482

  Fly   335 RNV---PKLRIND-----AEAEGELTLGHQARE-----VPQQEQPQEKQPCLEPEPP 378
            ..|   |:|.|:.     :.|...|.:|....|     |..|...:..|...|.|||
Human   483 SCVASGPRLFISQVTPGGSAARAGLQVGDVILEVNGYPVGGQNDLERLQQLPEAEPP 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42319	NP_001137648.1	PDZ_signaling	45..119	CDD:238492	19/75 (25%)
PDZD3	XP_011541302.1	PDZ_signaling	113..193	CDD:238492
		PDZ_signaling	221..298	CDD:238492	20/99 (20%)
		PDZ	326..411	CDD:214570	25/99 (25%)
		PDZ_signaling	466..545	CDD:238492	19/74 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900