DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42319 and Grip1

DIOPT Version :9

Sequence 1:	NP_001137648.1	Gene:	CG42319 / 36473	FlyBaseID:	FBgn0259219	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	XP_006514294.1	Gene:	Grip1 / 74053	MGIID:	1921303	Length:	1185	Species:	Mus musculus

Alignment Length:	387	Identity:	73/387 - (18%)
Similarity:	128/387 - (33%)	Gaps:	118/387 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 GFLITGGAEFHMPLTVFQVTPNGLADKAG-IRLGDIILEINEEDASQLTLSQAHEKINSTPKKIH 115
            |..|:|..|...|:.:..:|..|||::.| |.:||.||.||........||:|          ||
Mouse   740 GITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRILAINSSSLKGKPLSEA----------IH 794

  Fly   116 FLLRNMEEDDPMGQFEAGEEKSIVMRVPK-------------PLPPPSGRIRASSIEMRLLEMQR 167
            .|..            |||  ::.:::.|             |:|..||.:.....:...::...
Mouse   795 LLQM------------AGE--TVTLKIKKQTDAQSASSPKKFPIPGHSGDLGDGEEDPSPIQKPG 845

  Fly   168 KLSAIAEIPKILCSTLATVSQNFGRMSESEVDEDDVGEEEAYVQRKFSYDEDALDFELRNGEQAG 232
            |||      ....||:.:|.........|.:|.....:...:....::|:    .::.|:.:|..
Mouse   846 KLS------DAYPSTVPSVDSAVDSWDGSGIDASYGSQGSTFQTSGYNYN----TYDWRSPKQRT 900

  Fly   233 DTDSDEEDLVLVREEDAEDVDVPKGAKQSKLLKDV---TPESDYASEANYPANEASDDTESDDED 294
            ...                 .|||  .:|:...||   ..:.|.::.:.:..  |||..:::.|:
Mouse   901 SLS-----------------PVPK--PRSQTYPDVGLSNEDWDRSTASGFVG--ASDSADAEQEE 944

  Fly   295 EPGSTVYFMKLPAAAAEDTYSS------TEDEDDSD----FLNTTYTWNLRNVPKLRINDAEAEG 349
            ...|         .|.||..:.      .|.|:.:|    ..|.|....:.:...:.:|......
Mouse   945 NFWS---------QALEDLETCGQSGILRELEEKADRRVSLRNMTLLATIMSGSTMSLNHEAPMA 1000

  Fly   350 ELTLGHQA---------------------------REVPQQEQPQEKQPCLEPEPPKVRPAT 384
            ...||.||                           :.|..::..||.:..:.|.|.::...|
Mouse  1001 RSQLGRQASFQERSSSRPHYSQTTRSNTLPSDVGRKSVTLRKMKQEIKEIMSPTPVELHKVT 1062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42319	NP_001137648.1	PDZ_signaling	45..119	CDD:238492	23/67 (34%)
Grip1	XP_006514294.1	PDZ_signaling	110..190	CDD:238492
		PDZ_signaling	209..292	CDD:238492
		PDZ_signaling	307..390	CDD:238492
		PDZ_signaling	526..614	CDD:238492
		PDZ_signaling	627..711	CDD:238492
		PDZ_signaling	727..808	CDD:238492	26/91 (29%)
		PDZ_signaling	1058..1138	CDD:238492	1/5 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810