DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42319 and Pard3b

DIOPT Version :9

Sequence 1:	NP_001137648.1	Gene:	CG42319 / 36473	FlyBaseID:	FBgn0259219	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	XP_006496361.1	Gene:	Pard3b / 72823	MGIID:	1919301	Length:	1238	Species:	Mus musculus

Alignment Length:	376	Identity:	85/376 - (22%)
Similarity:	137/376 - (36%)	Gaps:	84/376 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PESKSKAPIIKVSCGIGDTDGYPAFDVDSDAYATKDDSRWGF-LITGGAEFHMPLTVF--QVTPN 73
            |.|.|.:|::    |.|.........:|    ..|.....|| ::|..:..|.|..:|  .:.|.
Mouse   397 PSSPSLSPLM----GFGSKKNAKKIKID----LKKGPEGLGFTVVTRDSSIHGPGPIFVKNILPK 453

  Fly    74 GLADKAG-IRLGDIILEINEEDASQLTLSQAHEKINSTPKKIHFLLRNMEEDDPMGQFEAGEEKS 137
            |.|.|.| ::.||.|||:|..|.:           ..|.:::..:||:.::.:.:....|.:|.|
Mouse   454 GAAVKDGRLQSGDRILEVNGRDVT-----------GRTQEELVAMLRSTKQGETVSLVIARQEGS 507

  Fly   138 IVMRVPKPLPPPSGRIRASSIEMRLLEMQRKLSAIAEIPKILCSTLATVSQNFGRMSESEVDEDD 202
            .:.|..|. .|....:...|.|...||:....|..|.:...|            :.::|.....|
Mouse   508 FLPRELKG-EPDCYALSLESSEQLTLEIPLNDSGSAGLGVSL------------KGNKSRETGTD 559

  Fly   203 VGEEEAYVQRKFSYDEDALDFELRNGEQA----GDT---DSDEEDLVLVREEDAEDVDVPKGAKQ 260
            :|   .:::..........|..||..:|.    |:|   .|:.|.:..:|...:.:.:: :|..|
Mouse   560 LG---IFIKSIIHGGAAFKDGRLRMNDQLIAVNGETLLGKSNHEAMETLRRSMSMEGNI-RGMIQ 620

  Fly   261 SKLLKDVTPESDYASEANYPANEASDDTESDDEDEPGSTVYFMKLPAAAAEDTYSSTEDEDDSDF 325
            ..:|:  .||.        |..|.|   |......||    |.....|.      ||...:||..
Mouse   621 LVILR--RPER--------PLEELS---ECGALSRPG----FENCQEAL------STSRRNDSSI 662

  Fly   326 LNTTYTWNLRNVPK--LRINDAEAEGELTLGHQAREVPQQEQPQEKQPCLE 374
            |....|::.::..|  |..:|..||         .|||....|   .|.||
Mouse   663 LYPFGTYSPQDKRKDLLLPSDGWAE---------NEVPPSPPP---HPALE 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42319	NP_001137648.1	PDZ_signaling	45..119	CDD:238492	20/77 (26%)
Pard3b	XP_006496361.1	DUF3534	2..74	CDD:338230
		PDZ_signaling	236..323	CDD:238492
		PDZ	415..504	CDD:214570	24/103 (23%)
		PDZ_signaling	536..624	CDD:238492	17/103 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900