DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42319 and Dlg5

DIOPT Version :9

Sequence 1:	NP_001137648.1	Gene:	CG42319 / 36473	FlyBaseID:	FBgn0259219	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	XP_017171686.1	Gene:	Dlg5 / 71228	MGIID:	1918478	Length:	1931	Species:	Mus musculus

Alignment Length:	282	Identity:	62/282 - (21%)
Similarity:	108/282 - (38%)	Gaps:	74/282 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SVPESKSKAP-----IIKVS--------CGIGDTDGYPAFDVDSDAYATKDDSRWGFLITGGAEF 61
            ||.::..|.|     .||.|        || |:..|....:|:.|:.|...|.    |:.|..
Mouse  1502 SVGDTTKKTPDPRIVFIKKSQLDLGVHLCG-GNLHGVFVAEVEDDSPAKGPDG----LVPGDL-- 1559

  Fly    62 HMPLTVFQVTPNGLADKAGIRLGDIILE-INEEDASQLTLSQAHE---KINSTPKK---IHFLLR 119
                    :...|..|.....:.|:.:| :..:|:.:|.:...||   ::...|..   |..|..
Mouse  1560 --------ILEYGSLDMRSRTVEDVYVEMLKPKDSLRLKVQYRHEEFTRVKGLPGDSFYIRALYD 1616

  Fly   120 NMEEDDPMGQFEAGEEKSIVMRVPKPLPPPSGRIRASSIEMRLLEMQRKLSAIAEIPKILCSTLA 184
            .:.|.:|    |...:|..::.|...||.   .:..|.:..:|.|..:|:.. .:||     :..
Mouse  1617 RLAEVEP----ELSFKKDDILYVDDTLPQ---GVFGSWMAWQLDENAQKIQR-GQIP-----SKY 1668

  Fly   185 TVSQNFG-RMSESEVDEDDVGE------EEAYVQRKFSYDEDALDFELRNGEQAG------DTDS 236
            .:.|.|. |:|.|||.:|:..:      ..::.:||..:.        |:|.:.|      ||.|
Mouse  1669 VMDQEFSRRLSMSEVKDDNTAKTLSAAARRSFFRRKHKHK--------RSGSKDGKDLLALDTFS 1725

  Fly   237 DE-----EDLVLVREEDAEDVD 253
            ::     ||.|.:..:..:.||
Mouse  1726 NDSIPLFEDSVSLAYQRVQKVD 1747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42319	NP_001137648.1	PDZ_signaling	45..119	CDD:238492	14/80 (18%)
Dlg5	XP_017171686.1	Takusan	129..213	CDD:368141
		Smc	<141..564	CDD:224117
		PDZ_signaling	625..712	CDD:238492
		PDZ_signaling	<741..800	CDD:238492
		PDZ	1357..1439	CDD:214570
		dbPDZ_assoc	1437..1512	CDD:374667	3/9 (33%)
		PDZ	1513..1594	CDD:214570	19/95 (20%)
		SH3_DLG5	1610..1672	CDD:212794	15/74 (20%)
		GuKc	1744..1920	CDD:214504	2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900