DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42319 and PDLIM2

DIOPT Version :9

Sequence 1:	NP_001137648.1	Gene:	CG42319 / 36473	FlyBaseID:	FBgn0259219	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_067643.3	Gene:	PDLIM2 / 64236	HGNCID:	13992	Length:	602	Species:	Homo sapiens

Alignment Length:	287	Identity:	67/287 - (23%)
Similarity:	104/287 - (36%)	Gaps:	76/287 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 WGFLITGGAEFHMPLTVFQVTPNGLADKAGIRLGDIILEINEEDASQLTLSQAHEKINSTPKKIH 115
            |||.||||.:||.|:.|.:|...|.|..|.:|.||||:.||.|.|..:..::|..||..:|..:.
Human   263 WGFRITGGRDFHTPIMVTKVAERGKAKDADLRPGDIIVAINGESAEGMLHAEAQSKIRQSPSPLR 327

  Fly   116 FLLRNMEEDDPMGQFEAGEEKSIVMRVPKPLPPPSGRIRASSIEMRLLEMQRKLSAIAEIPKILC 180
            ..|...:...| ||....                      ||:|:.....|..:....|....|.
Human   328 LQLDRSQATSP-GQTNGD----------------------SSLEVLATRFQGSVRTYTESQSSLR 369

  Fly   181 STLATVSQNFGRMSE--SEVDEDDVGEEEAYVQRKFSY--------DEDALDFELRNGE------ 229
            |:.::.:....|...  |..........||.:.|.|..        ..|.|.:..|.|.
Human   370 SSYSSPTSLSPRAGSPFSPPPSSSSLTGEAAISRSFQSLACSPGLPAADRLSYSGRPGSRQAGLG 434

  Fly   230 QAGDT------------------DSDEEDLVL--------VREEDAEDVDVPKGAKQSKLLKDV- 267
            :|||:                  ||:...|:|        :.:|:.|....|:.:...:||::.
Human   435 RAGDSAVLVLPPSPGPRSSRPSMDSEGGSLLLDEDSEVFKMLQENREGRAAPRQSSSFRLLQEAL 499

  Fly   268 -------TP---ESDYASEANYPANEA 284
                   ||   .|..:.:::.||:.|
Human   500 EAEERGGTPAFLPSSLSPQSSLPASRA 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42319	NP_001137648.1	PDZ_signaling	45..119	CDD:238492	28/67 (42%)
PDLIM2	NP_067643.3	PDZ_signaling	259..330	CDD:238492	28/66 (42%)
		DUF4749	<462..505	CDD:292558	7/42 (17%)
		LIM_Mystique	536..588	CDD:188833
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10683
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003437
OrthoInspector	1	1.000	-	-		otm41321
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R15300
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	6.040