DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42319 and lnx2b

DIOPT Version :9

Sequence 1:	NP_001137648.1	Gene:	CG42319 / 36473	FlyBaseID:	FBgn0259219	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_998105.2	Gene:	lnx2b / 564464	ZFINID:	ZDB-GENE-040426-2500	Length:	678	Species:	Danio rerio

Alignment Length:	240	Identity:	50/240 - (20%)
Similarity:	87/240 - (36%)	Gaps:	69/240 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 VFQVTPNGLADKAG-IRLGDIILEINEEDASQLTLSQAHEKINSTPKKIHFLLRNMEEDDPMGQF 130
            :..:.|.|||.|.| :|..|.:|.||.:|....|...|.:.|.::..:::|::..:::...
Zfish   354 ILDLLPGGLAAKDGKLRNNDKVLGINGQDLRHGTPESAAQIIQASEMRVNFVVMRLQDVSE---- 414

  Fly   131 EAGEEKSI-VMRVPKP---------LPPPSGRIRASSIEMRLLEMQRKLSAI---------AEIP 176
            |.||.:|. ..|||:|         :..|.|...:....:.|.:..|:...|         :.:|
Zfish   415 EGGEGQSRGARRVPEPQYFRRHSEYMKEPPGGFSSQEKTVTLKKEPRQSLGITIAGGRDCRSRLP 479

  Fly   177 KILCSTL--------ATVSQNFGRMSESEVDEDDVGEEEAY---------------VQRKFSYDE 218
            ..:.|..        .||......:|.:.:|...:...||.               |.:.|:.||
Zfish   480 VYITSVQPVGCLHRDGTVKTGDVLLSINGIDLTHLTYNEAVTVLKTQTAQSTVTLRVIQTFADDE 544

  Fly   219 DALDFELRNGEQAGDTDSDEEDLVLVREEDAEDVDVPKGAKQSKL 263
                      ||.|::.|            .||:|..:|.|...:
Zfish   545 ----------EQDGESGS------------REDMDTMEGPKDDDI 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42319	NP_001137648.1	PDZ_signaling	45..119	CDD:238492	16/52 (31%)
lnx2b	NP_998105.2	RING	46..82	CDD:214546
		PDZ_signaling	210..291	CDD:238492
		PDZ_signaling	325..406	CDD:238492	16/51 (31%)
		PDZ_signaling	451..537	CDD:238492	11/85 (13%)
		PDZ_signaling	587..671	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900