DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42319 and Pdlim3

DIOPT Version :9

Sequence 1:	NP_001137648.1	Gene:	CG42319 / 36473	FlyBaseID:	FBgn0259219	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001361581.1	Gene:	Pdlim3 / 53318	MGIID:	1859274	Length:	364	Species:	Mus musculus

Alignment Length:	298	Identity:	64/298 - (21%)
Similarity:	106/298 - (35%)	Gaps:	105/298 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 WGFLITGGAEFHMPLTVFQVTPNGLADKAGIRLGDIILEINEEDASQLTLSQAHEKINS------ 109
            |||.::||.:|:.||.:.::||...|..|.:..||:||.|:......:|.:.|.::|.:
Mouse    13 WGFRLSGGIDFNQPLVITRITPGSKAAAANLCPGDVILAIDGFGTESMTHADAQDRIKAASYQLC 77

  Fly   110 -----------TPK-----KIHFLLRNME-EDDPMGQFEAGEEKSIVMRVPKPLPPPSGRIRASS 157
                       :|:     |.|....|:| |...:..|   |.|..:.  |||...|.   |.|.
Mouse    78 LKIDRAETRLWSPQVSEDGKAHPFKINLEAEPQDVNYF---EHKHNIR--PKPFIIPG---RTSG 134

  Fly   158 IEMRLLEMQRKLSAIAEIPKILCSTLATVSQNFGRMSESEVD--------EDDVGEEEA------ 208
                                  |||.:.|....||.:.|.|.        :..|..:.|
Mouse   135 ----------------------CSTPSGVDCGSGRSTPSSVSTVSTICPGDLKVAAKMAPNIPLE 177

  Fly   209 -------YVQRKFS-----YDEDALDFELRNGEQA---GDTDSDEE---------DLVLVREEDA 249
                   .|..:|:     |.:|.: .|...|:.|   |:|.|..|         |:..:..::.
Mouse   178 MELPGVKIVHAQFNTPMQLYSDDNI-METLQGQVATALGETSSMSEPTASVPPQSDVYRMLHDNR 241

  Fly   250 EDVDVPKGAKQSKLLKDVTPESDYASEANYPANEASDD 287
            :|...|:.:...::|:|:             .|:..||
Mouse   242 DDPAAPRQSGSFRVLQDL-------------VNDGPDD 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42319	NP_001137648.1	PDZ_signaling	45..119	CDD:238492	23/89 (26%)
Pdlim3	NP_001361581.1	PDZ_signaling	2..80	CDD:238492	20/66 (30%)
		DUF4749	184..268	CDD:374237	19/97 (20%)
		LIM_ALP	294..346	CDD:188834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100