DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42319 and Whrn

DIOPT Version :9

Sequence 1:	NP_001137648.1	Gene:	CG42319 / 36473	FlyBaseID:	FBgn0259219	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	XP_038965801.1	Gene:	Whrn / 313255	RGDID:	631330	Length:	969	Species:	Rattus norvegicus

Alignment Length:	484	Identity:	100/484 - (20%)
Similarity:	165/484 - (34%)	Gaps:	160/484 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 GFLITGGAEFHMPLTVFQVTPNGLADKAGIRLGDIILEINEEDASQLTLSQAHEKINSTPKKI-- 114
            ||.|.||:|..:.:.|..|.|..||:|.|:|:||.||.:|::..:::|.::|.:.:..:.|.:
  Rat   154 GFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAEAVKALKGSKKLVLS 218

  Fly   115 --------------HF---------------------LLRNMEED--DPMGQFEAGEEK--SIVM 140
                          |.                     .||..|:|  ..:...::|:||  ::|:
  Rat   219 VYSAGRIPGGYVTNHIYTWVDPQGRSTSPPSSLPHGSTLRQHEDDRRSALHLLQSGDEKKVNLVL 283

  Fly   141 RVPKPL------------------PPPSGRIRASSIEM--RLLEMQRK--LSAI-AEIPKILCST 182
            ...:.|                  ..|.....:|.:::  ::||:..:  ||.: .|..|:|.|:
  Rat   284 GDGRSLGLTIRGGAEYGLGIYITGVDPGSEAESSGLKVGDQILEVNGRSFLSILHDEAVKLLKSS 348

  Fly   183 --LATVSQNFGRMSESEVDEDD--------VGE-------------EEAYVQRKFSYDEDALDFE 224
              |....::.||:..:....|.        :||             ||...:..|..........
  Rat   349 RHLILTVKDVGRLPHARTTVDQTKWIASSRIGESITNSAGFPGDLTEEGTNKPGFYKGPAGSQVT 413

  Fly   225 LRN-GEQAGDTDSDEEDLVLVREEDAE---DVDVPKGAKQS------------------KLLKDV 267
            |.: |.|......|:...:|..:|.|.   .:|..:|...|                  .||.:|
  Rat   414 LSSLGNQTRALLDDQARHLLTEQERATMMYYLDQYRGGTISVEALVMALFELLNTHAKFSLLSEV 478

  Fly   268 ----TPES----DY--------ASEANYPANEASDDTESDDEDEPGSTVYFMKLPAAAAEDTYSS 316
                :|:.    |:        :.:|..|......||.|                ..:..||.||
  Rat   479 RGIISPQDLDRFDHLVLRREIESMKARQPPGPGVGDTYS----------------MVSYSDTGSS 527

  Fly   317 TEDEDDSDFLNTT---YTWNLRNVPKLRIN--DAEAEGELTLGHQAR----EVPQQEQPQEKQPC 372
            |.....|..:::.   ..|.:    .|..|  |.|..||.|.|....    .|.....|.|..|.
  Rat   528 TGSHGTSTTVSSARERLLWLI----DLMENTLDLEGTGETTQGSTNALPDVSVDDVRSPSEDLPG 588

  Fly   373 LEPEPPKVRPATPTPKAPPQESAEGQTQK 401
            ::|.||      |.|.|...:...|||:|
  Rat   589 IKPPPP------PPPLAQGHDRLLGQTRK 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42319	NP_001137648.1	PDZ_signaling	45..119	CDD:238492	23/103 (22%)
Whrn	XP_038965801.1	HN_L-whirlin_R1_like	38..113	CDD:259822
		PDZ_signaling	139..216	CDD:238492	22/61 (36%)
		PDZ_signaling	276..356	CDD:238492	15/79 (19%)
		HN_L-whirlin_R2_like	418..498	CDD:259823	14/79 (18%)
		PDZ_signaling	<908..949	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900