DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42319 and Ush1c

DIOPT Version :9

Sequence 1:	NP_001137648.1	Gene:	CG42319 / 36473	FlyBaseID:	FBgn0259219	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	XP_006229284.1	Gene:	Ush1c / 308596	RGDID:	1303329	Length:	910	Species:	Rattus norvegicus

Alignment Length:	365	Identity:	83/365 - (22%)
Similarity:	128/365 - (35%)	Gaps:	91/365 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 GFLITGGAEFHMPLTVFQVTPNGLADKAGIRLGDIILEINEEDASQLTLSQAHEKINSTPKKIHF 116
            |..|:.|......:.|..|.|..|:.:.|:..||.|:|:|..|.:.|...:|...:.|:......
  Rat   223 GCSISSGPIQKPGIFVSNVKPGSLSAEVGLETGDQIVEVNGIDFTNLDHKEAVNVLKSSRSLTIS 287

  Fly   117 LLRNMEEDDPMGQFEAGEEKSIVMRVPKPLPPPSGRIRASSIEMRLLEMQRKLSAIAEIPKILCS 181
            ::             ||..:.:.|...:.|.    ..|...::.:.|.||::|:  .|..|||
  Rat   288 IV-------------AGAGRELFMTDRERLE----EARQHELQRQELLMQKRLA--MESNKIL-- 331

  Fly   182 TLATVSQNFGRMSESEVDEDDVGEEEAYVQRKFSYDEDALDFELRNGEQAGDTDSDEEDLVLVRE 246
               ...|...|....|:.:....|.|.|.:......|:...|:.:..|..|    .:|.|:|.:.
  Rat   332 ---QEQQEMERQRRKEIAQKAAEENERYRKEMEQISEEEEKFKKQWEEDWG----SKEQLILPKT 389

  Fly   247 EDAEDVDVP---------------------KGAKQSKLLKDVTPESDYASEANYPANEASDDTES 290
            ..||...||                     |.||:.|..|       |.|..:...|:...:.|.
  Rat   390 ITAEVHPVPLRKPKSFGWFYRYDGKFPTIRKKAKEKKKAK-------YDSLQDLRKNKKELEFEQ 447

  Fly   291 ---DDEDEPGSTVYFMKLPAAAAEDTYSSTEDEDDSDFLNTTYTWNLRNVPKL------RINDAE 346
               .:::|.......:|:...|.|  .|.||.||..:...|.| |    |.:|      :|:.||
  Rat   448 KLYKEKEEMLEKEKQLKINRLAQE--VSETEREDLEESEKTQY-W----VERLCQTRLQQISSAE 505

  Fly   347 AE-GELTLGHQAREVPQQEQPQEKQPCLEPEPPKVRPATP 385
            .| .|:|.|.                  .|.||.|.|..|
  Rat   506 NEITEMTTGP------------------PPPPPSVSPLVP 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42319	NP_001137648.1	PDZ_signaling	45..119	CDD:238492	17/66 (26%)
Ush1c	XP_006229284.1	harmonin_N	2..80	CDD:259819
		PDZ_signaling	85..165	CDD:238492
		PDZ_signaling	209..289	CDD:238492	17/65 (26%)
		Cgr1	<316..>358	CDD:281823	14/48 (29%)
		PDZ_signaling	751..838	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900