DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42319 and Mpdz

DIOPT Version :9

Sequence 1:	NP_001137648.1	Gene:	CG42319 / 36473	FlyBaseID:	FBgn0259219	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	XP_006238402.1	Gene:	Mpdz / 29365	RGDID:	3105	Length:	2068	Species:	Rattus norvegicus

Alignment Length:	496	Identity:	106/496 - (21%)
Similarity:	174/496 - (35%)	Gaps:	114/496 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PEQLGLLWSVPESKSKAPIIKVSCGIGDTDGYPAFDVDSDAYATKDDSRWGFLITG--GAEFHMP 64
            |..||:..|...|.|:   ::|.......:....|||:    .||:....|..|.|  |.:...|
  Rat   345 PSSLGITLSSSTSTSE---MRVDASTQKNEESETFDVE----LTKNVQGLGITIAGYIGDKKLEP 402

  Fly    65 LTVF--QVTPNGLADKAG-IRLGDIILEINEEDASQLTLSQAHEKINSTPKKIHFLLRN------ 120
            ..:|  .:|.:...:..| |::||.|:.::..:....|..||.|.:..|.:.:...|..
  Rat   403 SGIFVKSITKSSAVELDGRIQIGDQIVAVDGTNLQGFTNQQAVEVLRHTGQTVRLTLMRKGASQE 467

  Fly   121 ----------MEEDDPMGQFEAGEEKSIVMRVPKPLPPPSGRIRASSIEMRLLE-MQRKLSAIAE 174
                      .:.|.|...:|..||...:.|....||.........|.|:...| :|::.:.:.:
  Rat   468 AEITSREDTAKDVDLPAENYEKDEESLSLKRSTSILPIEEEGYPLLSTELEETEDVQQEAALLTK 532

  Fly   175 IPKIL---------------------CSTLATVSQNFGRMSESEVDEDDVGEEEAYVQRKFSYDE 218
            ..:|:                     .|..|||..:|.|   |.:.|..||    :..:.||.||
  Rat   533 WQRIMGINYEIVVAHVSKFSENSGLGISLEATVGHHFIR---SVLPEGPVG----HSGKLFSGDE 590

  Fly   219 DALDFELRNGEQAGDTDSDEEDLVLVREEDAEDV-------DVPKGAKQSKLLKDV-------TP 269
               ..|:......|:   :.:|:|.:.:|...||       .||..|.......|:       .|
  Rat   591 ---LLEVNGINLLGE---NHQDVVNILKELPIDVTMVCCRRTVPPTALSEVDSLDIHDLELTEKP 649

  Fly   270 ESDY-----ASEANYPANEASDDTESDDEDEPGSTVYFMKLPAAAAED-----TYSSTEDEDDSD 324
            ..|.     :||...|....||..::.:|.:....::...:.|...|.     .:|..:.:|..|
  Rat   650 HIDLGEFIGSSETEDPMLAMSDVDQNAEEIQTPLAMWEAGIQAIELEKGSRGLGFSILDYQDPID 714

  Fly   325 FLNTTYTWNLRNVPKLRINDAEAEGELTLGHQAREVP----QQEQPQEKQPCLEPEPP---KVRP 382
            ..||...  :|::....|  ||.:|.|..|.:...|.    :....:|....|:..|.   ::..
  Rat   715 PANTVIV--IRSLVPGGI--AEKDGRLFPGDRLMFVNDINLENSTLEEAVEALKGAPSGMVRIGV 775

  Fly   383 ATPTPKAP---------------PQESAE-GQTQKLLFRLD 407
            |.|.|.:|               |....| |.:.|.|||.|
  Rat   776 AKPLPLSPEEGYVSAKEDTFLCSPHTCKEMGLSDKALFRAD 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42319	NP_001137648.1	PDZ_signaling	45..119	CDD:238492	19/78 (24%)
Mpdz	XP_006238402.1	L27_2	6..63	CDD:117611
		PDZ_signaling	140..222	CDD:238492
		PDZ_signaling	256..335	CDD:238492
		PDZ	374..463	CDD:214570	23/92 (25%)
		PDZ_signaling	552..621	CDD:238492	21/81 (26%)
		PDZ_signaling	693..776	CDD:238492	17/86 (20%)
		PDZ_signaling	993..1063	CDD:238492
		PDZ_signaling	1150..1241	CDD:238492
		PDZ	1348..1433	CDD:214570
		PDZ_signaling	1482..1561	CDD:238492
		MPDZ_u10	1563..1624	CDD:293272
		PDZ	1625..1709	CDD:214570
		PDZ_signaling	1721..1801	CDD:238492
		PDZ_signaling	1858..1943	CDD:238492
		PDZ_signaling	1984..2067	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810