DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42319 and Pdlim2

DIOPT Version :9

Sequence 1:	NP_001137648.1	Gene:	CG42319 / 36473	FlyBaseID:	FBgn0259219	Length:	452	Species:	Drosophila melanogaster
Sequence 2:	NP_001007623.1	Gene:	Pdlim2 / 290354	RGDID:	1359203	Length:	349	Species:	Rattus norvegicus

Alignment Length:	290	Identity:	65/290 - (22%)
Similarity:	107/290 - (36%)	Gaps:	85/290 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 WGFLITGGAEFHMPLTVFQVTPNGLADKAGIRLGDIILEINEEDASQLTLSQAHEKINSTPKKIH 115
            |||.|:||.:||.|:.|.:||..|.|:.|.:|.||||:.||.|.|..:..::|..||..:...:.
  Rat    13 WGFRISGGRDFHTPIIVTKVTERGKAEAADLRPGDIIVAINGESAESMLHAEAQSKIRQSASPLR 77

  Fly   116 FLLRNMEEDDPMGQFEAGEEKSIVMRV----------------------------PKP-----LP 147
            ..|...:...| ||...  |.|:.|..                            |:|     .|
  Rat    78 LQLDRSQTASP-GQING--EGSLDMLATRFQGSLRTHHNSQSSQRSACFSPASLSPRPDSPFSTP 139

  Fly   148 PPSGRIRASSIEMRLLEMQRKLSAIAEIPKILCSTLAT-----VSQNFGRMSESEVDEDDVGEEE 207
            ||:..|..|...:.....|    ::...|.:..:...|     .||..|..|.|          :
  Rat   140 PPTSPIALSGENVIGCSFQ----SLTHSPGLAATHHLTYPGQPTSQQAGHSSPS----------D 190

  Fly   208 AYVQ-------RKFSYDEDALDFELRNGEQAGDTDSDEEDLVLVREEDAEDVDVPKGAKQSKLLK 265
            :.|:       |..|....:||.|            ::.::..:.:|:.:....|:.:...:||:
  Rat   191 STVRVLLHSPGRPSSPRLSSLDLE------------EDSEVFKMLQENRQGRAAPRQSSSFRLLQ 243

  Fly   266 DV--------TP---ESDYASEANYPANEA 284
            :.        ||   .|..:.:|:.|.:.|
  Rat   244 EALEAEERGGTPAFVPSSLSPKASLPTSRA 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42319	NP_001137648.1	PDZ_signaling	45..119	CDD:238492	27/67 (40%)
Pdlim2	NP_001007623.1	PDZ_signaling	9..80	CDD:238492	27/66 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..95		4/25 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..147		6/38 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	168..212		9/53 (17%)
		DUF4749	<190..252	CDD:292558	10/73 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..272		5/21 (24%)
		LIM_Mystique	283..335	CDD:188833
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003437
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24214
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100